Combination compositions
US-2018369452-A1 · Dec 27, 2018 · US
US12115264B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12115264-B2 |
| Application number | US-202117372424-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 10, 2021 |
| Priority date | Mar 10, 2014 |
| Publication date | Oct 15, 2024 |
| Grant date | Oct 15, 2024 |
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Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
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What is claimed is: 1. A method for sterilizing a liquid peptide composition, wherein the peptide in the liquid peptide composition comprises IEIK13 as set forth in SEQ ID NO:3, and wherein the peptide is N-terminal acetylated and/or C-terminal amidated, the method comprising subjecting the liquid peptide composition to heat treatment performed at about 121° C. for about 25 minutes. 2. The method of claim 1 , wherein the method does not involve sterilizing filtration. 3. The method of claim 1 , wherein the liquid peptide composition has a peptide concentration within the range of about 0.01% and about 10%. 4. The method of claim 1 , wherein the method does not degrade the peptide. 5. A method for sterilizing a liquid peptide composition, wherein the peptide in the liquid peptide composition comprises IEIK13 as set forth on SEQ ID NO:3, and wherein the peptide is N-terminal acetylated and/or C-terminal amidated, the method comprising subjecting the liquid peptide composition to autoclave treatment. 6. The method of claim 5 , wherein the method does not involve sterilizing filtration. 7. The method of claim 5 , wherein the liquid peptide composition has a peptide concentration within the range of about 0.01% and about 10%. 8. The method of claim 5 , wherein the method does not degrade the peptide.
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