Compound preparation for neuranagenesis, and preparation method therefor and use thereof

Patent metadata

Field	Value
Publication number	US-12115204-B2
Application number	US-202117790646-A
Country	US
Kind code	B2
Filing date	Jan 5, 2021
Priority date	Jul 20, 2020
Publication date	Oct 15, 2024
Grant date	Oct 15, 2024

Abstract

Disclosed are a compound preparation for neuranagenesis, and a preparation method therefor and the use thereof. The compound preparation for neuranagenesis comprises the raw medicinal materials in parts by weight: 10-20 parts of raw Astragali radix , 10-20 parts of Rehmaimiae Radix praeparata , 10-20 parts of Actyranthes bidentata , 6-15 parts of Jujubae fructus , 6-15 parts of Lycii fructus , 6-15 parts of parched Ziziphi spinosae semen, 6-12 parts of Angelicae smensis radix , 3-9 parts of Carthami flos , 6-15 parts of Poria , 6-15 parts of parched Atractylodis macrocephalae rhizoma and 10-20 parts of Zaocys . The compound preparation can be used for preparing drugs to treat nerve damage diseases, and can be prepared into oral liquids, granules, dissolved granules and tablets.

First claim

What is claimed is:

1. A compound preparation for neuranagenesis, wherein the compound preparation comprises the raw medicinal materials in parts by weight:
10-20 parts of raw Astragali radix, 10-20 parts of Rehmanniae Radix praeparata, 10-20 parts of Achyranthes bidentata, 6-15 parts of Jujubae fructus, 6-15 parts of Lycii fructus, 6-15 parts of parched Ziziphi spinosae semen, 6-12 parts of Angelicae sinensis radix, 3-9 parts of Carthami flos, 6-15 parts of Poria, 6-15 parts of parched Atractylodis macrocephalae rhizoma and 10-20 parts of Zaocys , and
the dosage form of the compound preparation for neuranagenesis comprises oral liquid prepared by:
soaking the raw materials in deionized water at 25° C. for 120 min;
performing water extraction, and decocting at 100° C. for 20 min;
taking the decoction and allowing same to stand at 4° C. for 12 h under sterile conditions, performing filtration and concentration, and adding benzoic acid or sodium benzoate; and
performing filling and sterilization to obtain the oral liquid.

2. The compound preparation for neuranagenesis according to claim 1 , wherein the compound preparation comprises the raw medicinal materials in parts by weight:
15 parts of raw Astragali radix, 15 parts of Rehmanniae Radix praeparata, 15 parts of Achyranthes bidentata, 10 parts of Jujubae fructus, 10 parts of Lycii fructus, 10 parts of parched Ziziphi spinosae semen, 6 parts of Angelicae sinensis radix, 3 parts of Carthami flos, 10 parts of Poria, 10 parts of parched Atractylodis macrocephalae rhizoma and 15 parts of Zaocys.

3. The compound preparation for neuranagenesis according to claim 2 , wherein the compound preparation also comprises an effective dose of the formulation components of the compound preparation and pharmaceutically acceptable excipients.

4. A method for preparing the compound preparation for neuranagenesis according to claim 3 , wherein when the dosage form of the compound preparation is oral liquid, the preparation method further comprises the following step:
preparing raw materials in parts by weight: 15 parts of raw Astragali radix, 10 parts of Jujubae fructus, 15 parts of Rehmanniae Radix praeparata, 10 parts of Lycii fructus, 15 parts of Achyranthes bidentata, 10 parts of parched Ziziphi spinosae semen, 6 parts of Angelicae sinensis radix, 3 parts of Carthami flos, 10 parts of Poria, 10 parts of parched Atractylodis macrocephalae rhizoma and 15 parts of Zaocys , and rinsing the medicinal materials with water to remove impurities.

5. A method for preparing the compound preparation for neuranagenesis according to claim 3 , wherein when the dosage form of the compound preparation is granules, the preparation method further comprises the following step:
preparing raw materials in parts by weight: 15 parts of raw Astragali radix, 10 parts of Jujubae fructus, 15 parts of Rehmanniae Radix praeparata, 10 parts of Lycii fructus, 15 parts of Achyranthes bidentata, 10 parts of parched Ziziphi spinosae semen, 6 parts of Angelicae sinensis radix, 3 parts of Carthami flos, 10 parts of Poria, 10 parts of parched Atractylodis macrocephalae rhizoma and 15 parts of Zaocys , and rinsing the medicinal materials with water to remove impurities.

6. A method of treating nerve damage diseases comprising administering a therapeutically effective amount of the compound preparation for neuranagenesis according to claim 1 .

7. A compound preparation for neuranagenesis, wherein the compound preparation comprises the raw medicinal materials in granules:
15 parts of raw Astragali radix, 10 parts of Jujubae fructus, 15 parts of Rehmanniae Radix praeparata, 10 parts of Lycii fructus, 15 parts of Achyranthes bidentata, 10 parts of parched Ziziphi spinosae semen, 6 parts of Angelicae sinensis radix, 3 parts of Carthami flos, 10 parts of Poria, 10 parts of parched Atractylodis macrocephalae rhizoma and 15 parts of Zaocys , and rinsing the medicinal materials with water to remove impurities, and
the dosage form of the compound preparation for neuranagenesis comprises granules prepared by:
soaking the raw materials in deionized water at 25° C. for 120 min;
performing water extraction, and decocting at 100° ° C. for 20 min;
taking the decoction and allowing same to stand at 4° C. for 12 h under sterile conditions, performing filtration and concentration, and adding benzoic acid or sodium benzoate; and
performing drying, granulation, filling and sterilization to obtain the granules.

Assignees

• Univ Nantong

Inventors

• Gu Xiaosong
• Tang Chunkang
• Ding Fei
• Yang Xiaoming
• Cheng Qiong
• Sun Hualin
• Xu Lai

Classifications

• A61K35/583

  Snakes; Lizards, e.g. chameleons (therapeutic use of a snake venom protein A61K38/00) · CPC title

• A61K2236/51

  Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying · CPC title

• A61K2236/331

  using water, e.g. cold water, infusion, tea, steam distillation or decoction · CPC title

• A61K2236/13

  involving cleaning, e.g. washing or peeling · CPC title

• A61K36/815

  Lycium (desert-thorn) · CPC title