Blister pack and inhaler comprising the same

Patent metadata

Field	Value
Publication number	US-12109357-B2
Application number	US-202218052649-A
Country	US
Kind code	B2
Filing date	Nov 4, 2022
Priority date	Jun 15, 2020
Publication date	Oct 8, 2024
Grant date	Oct 8, 2024

Abstract

Provided is a blister pack for a dry powder inhaler, which dry powder inhaler is configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament. The first and second powder medicaments are contained within blister pockets defined in a strip. A series of blister pockets is defined in the strip, which series extends linearly along the length of the strip. The first and second powder medicaments are contained in blister pockets, e.g. respective blister pockets, of the series. Alternatively or additionally, each of the blister pockets is elongated such as to have a largest dimension parallel with the length of the strip. These measures, either individually or in combination, enable minimizing of the width of the strip in spite of the strip accommodating both the first and second powder medicaments. This, in turn, may enable the depth/thickness of the dry powder inhaler to be minimized, and/or additional space to be provided inside the dry powder inhaler for accommodating, for example, use detection and wireless connectivity electronics for sending use detection data to an external device, such as a smartphone.

First claim

The invention claimed is:

1. A dry powder inhaler configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament, the dry powder inhaler comprising:
a blister pack; and
a medicament delivery assembly,
wherein the blister pack comprises:
an elongated strip having blister pockets including a first series of blister pockets and a second series of blister pockets, wherein the first series and the second series are parallel with each other and extend along a length direction of the strip such that the first series and the second series overlap each other along the length direction, the first powder medicament being contained in the first series of blister pockets, and the second powder medicament being contained in the second series of blister pockets, wherein the strip is friable along a friable portion, the friable portion being elongated so as to have a length dimension extending along the length direction of the strip and arranged between the first series and the second series, and wherein the strip is folded along said friable portion to define a fold line extending in the length direction of the strip,
wherein the medicament delivery assembly is configured to:
separate the first series from the second series along the friable portion while the strip is folded along the friable portion by breaking the friable portion along the length dimension; and
access the blister pockets to permit a subject to inhale the first and second powder medicaments therefrom.

2. The dry powder inhaler according to claim 1 , wherein a first precursor strip comprising the first series is joined to a second precursor strip comprising the second series to form the strip.

3. The dry powder inhaler according to claim 1 further comprising:
a mouthpiece, wherein the medicament delivery assembly comprises a manifold configured such that the first and second powder medicaments from the accessed blister pockets are drawn simultaneously therethrough and out of the mouthpiece when the subject inhales through the mouthpiece.

4. The dry powder inhaler according to claim 3 , wherein the manifold comprises a first flow path along which the first powder medicament is carried towards the mouthpiece from one of the accessed blister pockets, and a second flow path along which the second powder medicament is carried towards the mouthpiece from the other of the accessed blister pockets.

5. The dry powder inhaler according to claim 1 , wherein at least part of each of the blister pockets of the first series is aligned with a respective blister pocket of the second series.

6. The dry powder inhaler according to claim 1 , wherein the medicament delivery assembly is configured to access at least one of said blister pockets of the first series and at least one of said blister pockets of the second series for each inhalation using the inhaler.

7. The dry powder inhaler according to claim 1 , wherein the medicament delivery assembly is configured to separate the first series from the second series prior to accessing the respective blister pockets of the first series and the second series.

8. The dry powder inhaler according to claim 1 , wherein the first series of blister pockets contain a different volume of the first powder medicament than a volume of the second powder medicament contained by the second series of blister pockets.

9. The dry powder inhaler according to claim 1 , wherein the friable portion comprises a perforation extending along the length direction of the strip and arranged between the first series and the second series.

10. The dry powder inhaler according to claim 1 , wherein the first series and the second series are formed integrally in the strip.

11. The dry powder inhaler according to claim 1 , wherein the blister pack further comprises a peelable cover for covering the blister pockets, wherein the blister pockets are defined in a base layer, and wherein the peelable cover is releasably adhered to the base layer between the blister pockets.

12. The dry powder inhaler according to claim 1 , wherein the medicament delivery assembly is configured to advance the strip by pulling or by pushing the strip.

13. The dry powder inhaler according to claim 1 , wherein:
the first powder medicament comprises budesonide and the second powder medicament comprises formoterol; or
the first powder medicament comprises beclomethasone and the second powder medicament comprises formoterol; or
the first powder medicament comprises fluticasone and the second powder medicament comprises salmeterol, or
the first powder medicament comprises fluticasone and the second powder medicament comprises albuterol, or
the first powder medicament comprises fluticasone and the second powder medicament comprises vilanterol, or
the first powder medicament comprises umeclidinium and the second powder medicament comprises vilanterol, or
the first powder medicament comprises two selected from umeclidinium, fluticasone and vilanterol, and the second powder medicament comprises the remaining medicament from umeclidinium, fluticasone and vilanterol not selected for the first powder medicament.

14. The dry powder inhaler according to claim 1 , wherein:
the first powder medicament comprises fluticasone furoate and the second powder medicament comprises vilanterol trifenatate, or the first powder medicament comprises umeclidinium bromide and the second powder medicament comprises vilanterol trifenatate, or the first powder medicament comprises two selected from umeclidinium bromide, fluticasone furoate and vilanterol trifenatate, and the second powder medicament comprises the remaining medicament from umeclidinium bromide, fluticasone furoate and vilanterol trifenatate not selected for the first powder medicament.

15. A dry powder inhaler configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament, the dry powder inhaler comprising:
a blister pack; and
a medicament delivery assembly,
wherein the blister pack comprises:
blister pockets including a first series of blister pockets and a second series of blister pockets; and
a first base layer in which the first series of blister pockets are defined, and a second base layer in which the second series of blister pockets are defined, the first powder medicament being contained in the first series of blister pockets, and the second powder medicament being contained in the second series of blister pockets,
wherein the blister pack further comprises a unitary cover for covering the first series of blister pockets and the second series of blister pockets, wherein the unitary cover comprises a first surface and a second surface facing away from the first surface, wherein the first surface and the second surface are opposite surfaces of the unitary cover, and the unitary cover is formed as a single web of material, such that the first surface and the second surface cannot be moved apart, the first series of blister pockets being covered by the first surface of the unitary cover, and the second series of blister pockets being covered by the second surface of the unitary cover,

wherein the medicament delivery assembly is configured to:
access the blister pockets and permit a subject to inhale the first and second powder medicaments therefrom.

16. The dry powder inhaler according to claim 15 , wherein the first base layer and the second base layer are peelable base layers, and the unitary cover is a peelable cover, and the first surface is releasably adhered to the first base layer between th

Assignees

• Norton Waterford Ltd

Inventors

• Crowley Peter John
• Hazenberg Jan Geert
• Buck Daniel
• Edlin Christopher David
• Shah Hardik Kirtikumar

Classifications

• A61M15/0021

  Mouthpieces therefor · CPC title

• A61M15/0003

  with means for dispensing more than one drug · CPC title

• A61M2202/064

  Powder · CPC title

• A61M15/0028

  using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up · CPC title

• A61M15/0025

  with caps · CPC title