Sealing agent for genitals

Patent metadata

Field	Value
Publication number	US-12109336-B2
Application number	US-202117510574-A
Country	US
Kind code	B2
Filing date	Oct 26, 2021
Priority date	Apr 28, 2017
Publication date	Oct 8, 2024
Grant date	Oct 8, 2024

Abstract

The present invention aims to provide a cervical canal sealant that can be used as a sealant to stop bleeding in the uterus and vaginal discharge, particularly, a cervical canal sealant that can block the cervical canal to inhibit amniotic fluid leakage and that can also be peeled off without damaging reproductive tissue. The present invention relates to a sealant for reproductive organs in which a cured product (X) at 25° C. has a storage modulus G′ of 200 to 2,000 kPa, the cured product (X) being a cured product obtained by curing the sealant for reproductive organs to a thickness of 120 to 150 μm.

First claim

The invention claimed is:

1. A method for sealing a reproductive organ, comprising:
applying a sealant to a reproductive organ,
curing the sealant, and
peeling off the cured sealant from the reproductive organ,
wherein the sealant comprises:
an NCO-terminated urethane prepolymer (UP) that is a reaction product of a polyisocyanate component (A) and a polyol component (B) containing a hydrophilic polyol (B1), wherein the polyisocyanate component (A) comprises a fluorine-containing non-aromatic polyisocyanate compound (A1), and the NCO-terminated urethane prepolymer (UP) has a fluorine content of 1 to 23 wt % based on the weight of the NCO-terminated urethane prepolymer (UP), and
when the sealant is spread to a thickness of 120 to 150 μm and cured, a sample of the sealant is obtained as a cured product (X) having a storage modulus G′ of 200 to 2,000 kPa at 25° C.

2. The method according to claim 1 ,
wherein the NCO-terminated urethane prepolymer (UP) has an isocyanate group content of 1 to 10 wt % based on the weight of the NCO-terminated urethane prepolymer (UP).

3. The method according to claim 1 ,
wherein the NCO-terminated urethane prepolymer (UP) has a total content of urethane groups and urea groups of 1 to 20 wt % based on the weight of the NCO-terminated urethane prepolymer (UP).

4. The method according to claim 1 ,
wherein the hydrophilic polyol (B1) has an oxyethylene unit content of 30 to 90 wt % based on the weight of the hydrophilic polyol (B1).

5. The method according to claim 1 ,
wherein the polyol component (B) has an oxyethylene unit content of 30 to 90 wt % based on the weight of the polyol component (B).

6. The method according to claim 1 ,
wherein the cured product (X) has a contact angle with water of 60° to 110°.

7. The method according to claim 1 ,
wherein the reproductive organ is a cervical canal.

8. A method for preventing amniotic fluid leakage from a uterus, comprising:
applying a sealant to a uterus,
curing the sealant, and
peeling off the cured sealant from the uterus,
wherein the sealant comprises:
an NCO-terminated urethane prepolymer (UP) that is a reaction product of a polyisocyanate component (A) and a polyol component (B) containing a hydrophilic polyol (B1), wherein the polyisocyanate component (A) comprises a fluorine-containing non-aromatic polyisocyanate compound (A1), and the NCO-terminated urethane prepolymer (UP) has a fluorine content of 1 to 23 wt % based on the weight of the NCO-terminated urethane prepolymer (UP), and
when the sealant is spread to a thickness of 120 to 150 μm and cured, a sample of the sealant is obtained as a cured product (X) having a storage modulus G′ of 200 to 2,000 kPa at 25° C. is obtained.

9. The method according to claim 8 ,
wherein the NCO-terminated urethane prepolymer (UP) has an isocyanate group content of 1 to 10 wt % based on the weight of the NCO-terminated urethane prepolymer (UP).

10. The method according to claim 8 ,
wherein the NCO-terminated urethane prepolymer (UP) has a total content of urethane groups and urea groups of 1 to 20 wt % based on the weight of the NCO-terminated urethane prepolymer (UP).

11. The method according to claim 8 ,
wherein the hydrophilic polyol (B1) has an oxyethylene unit content of 30 to 90 wt % based on the weight of the hydrophilic polyol (B1).

12. The method according to claim 8 ,
wherein the polyol component (B) has an oxyethylene unit content of 30 to 90 wt % based on the weight of the polyol component (B).

13. The method according to claim 8 ,
wherein the cured product (X) has a contact angle with water of 60° to 110°.

Assignees

• Sanyo Chemical Ind Ltd

Inventors

• Kondo Eiji
• Maeda Hiroaki
• Kawabata Shingo

Classifications

• C08G18/77

  having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur · CPC title

• C08G18/10

  Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step · CPC title

• A61L31/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} · CPC title

• C09J175/04

  Polyurethanes · CPC title

• C08G2190/00

  Compositions for sealing or packing joints · CPC title