System and method for local electrophysiological characterization of cardiac substrate using multi-electrode catheter

Patent metadata

Field	Value
Publication number	US-12109031-B2
Application number	US-201916593631-A
Country	US
Kind code	B2
Filing date	Oct 4, 2019
Priority date	Feb 25, 2014
Publication date	Oct 8, 2024
Grant date	Oct 8, 2024

Abstract

A system for determining electrophysiological data comprising an electronic control unit configured to acquire electrophysiology signals from a plurality of electrodes ( 130 ) of one or more catheters, select at least one clique of electrodes from the plurality of electrodes ( 136 ) to determine a plurality of local E field data points, determine the location and orientation of the plurality of electrodes, process the electrophysiology signals from the at least one clique from a full set of bipole subcliques to derive the local E field data points associated with the at least one clique of electrodes, derive at least one orientation independent signal from the at least one clique of electrodes ( 138 ) from the information content corresponding to weighted parts of electrogram signals, and display or output catheter orientation independent electrophysiologic information to a user or process.

First claim

What is claimed is:

1. A system for determining electrophysiological data comprising:
an electronic control unit configured to:
acquire electrophysiology signals from a plurality of electrodes of one or more catheters;
select at least one clique of electrodes from the plurality of electrodes to determine a plurality of local electric (E) field data points, wherein the at least one clique of electrodes comprises three electrodes;
process the electrophysiology signals from the at least one clique to derive the plurality of local E field data points associated with the at least one clique of electrodes, wherein each of the electrodes comprising the at least one clique of electrodes is associated with at least one of the plurality of local E field data points;
derive at least one orientation-independent bipolar electrophysiology signal from the plurality of local E field data points associated with the at least one clique of electrodes; and
output catheter-orientation-independent electrophysiologic information to a user or process.

2. The system according to claim 1 , wherein the electronic control unit is further configured to determine the location and orientation of the plurality of electrodes.

3. The system according to claim 2 , wherein the electronic control unit is further configured to use at least one criteria to determine whether each of the at least one clique is in contact with a target surface.

4. The system according to claim 3 , wherein the at least one criteria comprises at least one of an angular deviation, the characteristics of tangent bipole vector (Et), and a scalar version of Et along a unit activation direction (Ea) from a clique of the at least one clique.

5. The system according to claim 3 , wherein the at least one criteria comprises an amplitude of a unipolar signal obtained from each of the electrodes in a clique of the at least one clique and the morphology of unipolar signals obtained from the electrodes in the clique of the at least one clique.

6. The system according to claim 3 , wherein the electronic control unit is configured to receive one or more criteria from the user or process to determine whether each of the at least one clique is in contact with the target surface.

7. The system according to claim 1 , wherein the catheter-orientation-independent electrophysiologic information output by the electronic control unit is beat-by-beat information.

8. The system according to claim 1 , wherein the electronic control unit is further configured to:
weight the E field data points; and
derive the orientation-independent electrophysiologic information from the weighted E field data points.

9. The system according to claim 8 , wherein the electronic control unit is configured to derive at least one of a substrate voltage amplitude, local activation timing, or conduction velocity from the weighted E field data points.

10. The system according to claim 8 , wherein the plurality of E field data points form an E field loop, and wherein the electronic control unit is further configured to weight each of the E field data points based on the distance of point in the E field from an isoelectric origin.

11. The system according to claim 8 , wherein the plurality of E field data points form an E field loop, and wherein the electronic control unit is further configured to weight the data points in the E field loop based on |d/dt(E(t))|.

12. The system according to claim 8 , wherein the plurality of E field data points form an E field loop, and wherein the weight of the E field data points is determined from a weighting function that increases the weight in a region corresponding to the zero-crossing of Ea.

13. The system according to claim 1 , wherein the at least one clique of electrodes comprises a plurality of adjacent cliques.

14. The system according to claim 13 , wherein the electronic control unit is further configured to compute a local velocity vector for each of the plurality of adjacent cliques.

15. The system according to claim 14 , wherein the electronic control unit is further configured to determine a divergence and curl path integral and a path length.

16. The system according to claim 14 , wherein the electronic control unit is further configured to determine whether a uniform propagation, a rotor, a focal source, a collision site, or a scar is present within the plurality of adjacent cliques.

17. The system according to claim 16 , wherein the electronic control unit is further configured to score each of the plurality of adjacent cliques.

18. The system according to claim 17 , wherein the electronic control unit is further configured to compare the score of each of the plurality of adjacent cliques to at least one template.

19. The system according to claim 13 , wherein the electronic control unit is configured to calculate a score for a target clique from at least one clique adjacent to the target clique.

20. A method for determining electrophysiological data comprising:
acquiring electrophysiology signals from a plurality of electrodes of one or more catheters;
selecting at least one clique of electrodes from the plurality of electrodes to determine a plurality of local E field data points, wherein the at least one clique comprises three electrodes;
processing the electrophysiology signals from the at least one clique to derive the plurality of local E field data points associated with the at least one clique of electrodes, wherein each of the electrodes comprising the at least one clique of electrodes is associated with at least one of the plurality of local E field data points;
deriving at least one orientation-independent bipolar electrophysiology signal from the plurality of local E field data points associated with the at least one clique of electrodes; and
outputting catheter-orientation-independent electrophysiologic information to a user or process.

Assignees

• St Jude Medical Cardiology Div Inc

Inventors

• Deno D Curtis
• Balachandran Ram K

Classifications

• A61B5/367

  Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping · CPC title

• A61B5/339

  Displays specially adapted therefor · CPC title

• A61M2025/0166

  Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided · CPC title

• A61M25/0127

  Magnetic means; Magnetic markers · CPC title

• A61B2562/0214

  Capacitive electrodes · CPC title