Microfluidic device having separable structure using thin film
US-2021402393-A1 · Dec 30, 2021 · US
US12105116B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12105116-B2 |
| Application number | US-202117144301-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 8, 2021 |
| Priority date | Sep 13, 2018 |
| Publication date | Oct 1, 2024 |
| Grant date | Oct 1, 2024 |
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A disposable flow velocity measuring device including: a first panel having a flow velocity measuring structure, and having additional micro protrusion patterns formed around the flow velocity measuring structure; a second panel separated from the first panel, and including a fluid channel through which a sample passes; a porous ultra-thin film formed on a portion, at which the first panel and the second panel come in contact with each other, so that the sample passing through the fluid channel does not directly come in contact with the flow velocity measuring structure, thereby separating the first panel and the second panel and removing micro-air bubbles included in the fluid passing through the fluid channel; a non-porous ultra-thin film formed in a partial region of the porous ultra-thin film; and a negative pressure forming unit for applying negative pressure in order to adsorb the first panel and the second panel.
Opening claim text (preview).
The invention claimed is: 1. A disposable flow velocity measuring device, comprising: a first panel having a flow velocity measuring structure for measuring a flow velocity of fluid and having additional micro protrusion patterns around the flow velocity measuring structure; a second panel separated from the first panel and including a fluid channel through which a sample passes; a porous ultra-thin film formed on a portion at which the first panel and the second panel come in contact with each other so that the sample passing through the fluid channel does not directly come in contact with the flow velocity measuring structure to separate the first panel and the second panel and remove micro air bubbles included in the fluid passing through the fluid channel; a non-porous ultra-thin film formed in a partial region of the porous ultra-thin film; and a negative pressure forming unit which applies a negative pressure to adsorb the first panel and the second panel, wherein the flow velocity measuring structure includes: a heater which applies heats to a sample passing through the fluid channel; and two temperature measurement electrodes which are provided in upstream and downstream of the heater to measure a resistance difference according to a temperature change of the sample when the temperature of the sample rises due to the heat generated from the heater. 2. The disposable flow velocity measuring device of claim 1 , wherein the non-porous ultra-thin film is installed so as to correspond to a position of the flow velocity measuring structure. 3. The disposable flow velocity measuring device of claim 2 , wherein the non-porous ultra-thin film is installed on an upper portion of the porous ultra-thin film corresponding to the position of the flow velocity measuring structure to configure a two-layered ultra-thin film. 4. The disposable flow velocity measuring device of claim 3 , wherein the micro protrusion pattern is omitted in the first panel corresponding to a position of the non-porous ultra-thin film. 5. The disposable flow velocity measuring device of claim 1 , wherein the non-porous ultra-thin film includes at least one material selected from the group consisting of polydimethyl siloxane (PDMS), polyethylene terephthalate (PET), polyimide (PI), polypropylene (PP), poly(methyl methacrylate) (PMMA), polycaprolactone, polystyrene, propylene carbonate, ethylene carbonate, dimethylcarbonate, diethylcarbonate, polymer plastic, glass, paper, and ceramics. 6. The disposable flow velocity measuring device of claim 1 , wherein the micro protrusion patterns are formed to protrude on a surface of the first panel with a predetermined interval so as to prepare a passage for discharging micro air bubbles leaked through the porous ultra-thin film to the outside. 7. The disposable flow velocity measuring device of claim 6 , wherein a height of the micro protrusion pattern is 3 to 7 μm. 8. The disposable flow velocity measuring device of claim 1 , wherein the porous ultra-thin film has hydrophobicity so as not to pass the fluid flowing through the fluid channel but pass only the micro air bubbles included in the fluid to be leaked to the first panel. 9. The disposable flow velocity measuring device of claim 8 , wherein the porous ultra-thin film includes at least one material selected from the group consisting of polydimethyl siloxane (PDMS), polyethylene terephthalate (PET), polyimide (PI), polypropylene (PP), poly(methyl methacrylate) (PMMA), polycaprolactone, polystyrene, propylene carbonate, ethylene carbonate, dimethylcarbonate, diethylcarbonate, polymer plastic, glass, paper, and ceramics. 10. The disposable flow velocity measuring device of claim 1 , wherein the negative pressure forming unit includes a negative pressure forming groove formed on a surface where the first panel and the second panel come in contact with each other; a vacuum suction unit which communicates with the negative pressure forming groove to apply a negative pressure to adsorb the first panel and the second panel with the negative pressure so as to completely remove an air layer between the first panel and the second panel. 11. The disposable flow velocity measuring device of claim 10 , wherein the negative pressure forming groove is formed on a lower surface of the second panel and the vacuum suction unit is formed to communicate with an upper surface or a side surface of the second panel. 12. The disposable flow velocity measuring device of claim 10 , wherein the negative pressure forming groove is formed with a shape and in a position enclosing the fluid channel.
Laminated structure · CPC title
vacuum · CPC title
using resistive heater · CPC title
Cards, e.g. flat sample carriers usually with flow in two horizontal directions · CPC title
Electrodes · CPC title
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