Labeling composition for cancer lesion
US-10166302-B2 · Jan 1, 2019 · US
US12104069B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12104069-B2 |
| Application number | US-201816755359-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 1, 2018 |
| Priority date | Oct 11, 2017 |
| Publication date | Oct 1, 2024 |
| Grant date | Oct 1, 2024 |
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The present invention provides an epidermal penetration type ink composition comprising: a fluorescent colorant containing at least one selected from the group consisting of indocyanine green (ICG), cyanine, phthalocyanine, oxazine, rhodamine, and a mixture thereof; a binder resin containing at least one of polyvinylpyrrolidone (PVP) and polyvinylbutyral (PVB); and a solvent containing at least one of ethanol and isopropanol.
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The invention claimed is: 1. An ink composition which penetrates into the stratum corneum of the skin, comprising: a fluorescent colorant, wherein the fluorescent colorant is indocyanine green (ICG); a binder resin, wherein the binder resin is a combination of polyvinylpyrrolidone (PVP) and polyvinyl butyral (PVB); and a solvent, wherein the solvent is ethanol, wherein a concentration of fluorescent colorant is in the range of 0.02 mM to 20 mM, a concentration of the combination of PVP and PVB is the range of 3 to 5 wt % relative to the total composition of 100 wt %, and an amount of the ethanol is in the range of 5 to 10 wt % relative to the total composition of 100 wt %. 2. The ink composition of claim 1 , wherein the concentration of the ICG is in the range of 1 mM to 5 mM. 3. The ink composition of claim 1 , wherein amounts of the PVP and the PVB are in the range of 0.9 to 1.8 wt % and 2.7 to 3.6 wt %, respectively, relative to the total composition of 100 wt %. 4. The ink composition of claim 1 , further comprising an additional solvent, which is isopropanol.
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