Two-part dental sealant, method of applying with a syringe device, and kit

Patent metadata

Field	Value
Publication number	US-12102499-B2
Application number	US-201917247244-A
Country	US
Kind code	B2
Filing date	Jun 4, 2019
Priority date	Jun 6, 2018
Publication date	Oct 1, 2024
Grant date	Oct 1, 2024

Abstract

A method of applying a two-part dental sealant is described comprising providing a syringe device ( 1 ) comprising a cartridge ( 10 ) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle ( 17 ) comprising a static mixer and an outlet at one end of the cartridge and a plunger ( 20 ) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.

First claim

What is claimed is:

1. A two-part dental sealant composition comprising:
a first part comprising a (meth)acrylate resin and an oxidizing curing agent,
the first part characterized by a viscosity of no greater than 5000 cps;

a second part comprising a (meth)acrylate resin and a reducing curing agent,
the second part characterized by a viscosity of no greater than 5000 cps; and

an encapsulated material comprising:
a core comprising:
a basic material or a basic compound characterized by a pKa of 8-14, and
a source of calcium ions derived from the basic material or the basic compound, a calcium compound other than the basic material or the basic compound, or a combination thereof; and

a shell comprising a metal oxide,

wherein the shell surrounds the core, and
wherein the shell degrades, dissolves, or decomposes upon contact with water or an acidic component.

2. The two-part dental sealant composition of claim 1 , wherein one or more of:
the oxidizing curing agent is a peroxide; and
the reducing curing agent is an amine.

3. The two-part dental sealant composition of claim 1 , wherein the (meth)acrylate resin of the first part and the (meth)acrylate resin of the second part each comprise bisphenol A glycidyl methacrylate and triethylene glycol dimethacrylate.

4. The two-part dental sealant composition of claim 1 , the core further comprising a source of phosphorus ions, fluoride ions, or a combination thereof.

5. The two-part dental sealant composition of claim 1 , the core comprising tricalcium silicate, dicalcium silicate, calcium silicate, tricalcium aluminate, tetracalcium aluminoferrite, or a combination thereof.

6. The two-part dental sealant composition of claim 1 , the core further comprising magnesium oxide, calcium oxide, potassium sulfate, sodium sulfate, or a combination thereof.

7. The two-part dental sealant composition of claim 1 , the core comprising a bioactive glass.

8. The two-part dental sealant composition of claim 1 , wherein the basic material or the basic compound is present in an amount of at least 25 wt % based on the weight of the core.

9. The two-part dental sealant composition of claim 1 , wherein the shell has a thickness of up to 500 nm.

10. The two-part dental sealant composition of claim 1 , further comprising a photoinitiator.

11. A kit for storing and applying a dental sealant comprising:
i) a syringe device comprising:
a) a cartridge including a first chamber and a second chamber,
b) a plunger comprising a first rod and a second rod, wherein the first rod seals the first chamber and the second rod seals the second chamber, and
c) at least one dispensing nozzle comprising a static mixer and an outlet,
wherein the at least one dispensing nozzle is attached to an end of the cartridge that is opposite the plunger; and

ii) a two-part dental sealant composition of claim 1 ,
wherein the first part is located in the first chamber, and
wherein the second part is located in the second chamber.

12. The kit of claim 11 , the cartridge characterized by a volume no greater than 5 cc.

13. The kit of claim 11 , the first chamber and second chamber having a volume ratio of about 1:1.

14. The kit of claim 11 , the dispensing nozzle characterized by a volume no greater than 0.25 cc.

15. The kit of claim 11 , the outlet characterized by a diameter of no greater than 1.5 mm.

16. A method of applying a two-part dental sealant comprising:
providing a kit of claim 11 ; and
applying pressure to the plunger thereby conveying the first part and the second part of the two-part dental sealant through the static mixer and the outlet onto a tooth surface.

17. The method of claim 16 , wherein the two-part dental sealant composition cures when the first part and the second part are combined without exposure to actinic radiation.

18. The method of claim 16 , wherein the two-part dental sealant composition cures when the first part and the second part combined within 5 minutes.

19. The method of claim 16 , further comprising conditioning the tooth surface, wherein the conditioning is performed prior to applying the dental sealant.

20. The method of claim 19 , wherein the conditioning comprises etching, priming, abrading, or a combination thereof.

Assignees

• 3M Innovative Properties Company
• Solventum Intellectual Properties Company

Inventors

• Christensen Randilynn B
• Budd Kenton D
• Falsafi Afshin
• Aksit Mahmut
• Ninkovic Jana
• Liu Jie J
• Agre Mark B
• Nakamura Masayuki
• Bjork Jason W
• Craig Bradley D
• Rusin Richard P
• Homnick Paul J
• Oxman Joel D
• Wang Yizhong
• Klaiber Paul R
• Dodge Bill H

Classifications

• A61K6/79

  Initiators · CPC title

• A61K6/62

  Photochemical radical initiators · CPC title

• A61K6/61

  Cationic, anionic or redox initiators · CPC title

• A61K6/887

  Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• B01F35/7164

  the containers being placed in parallel before contacting the contents · CPC title