Imageable polymers
US-2015110722-A1 · Apr 23, 2015 · US
Radiopaque polymers
US12098220B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12098220-B2 |
| Application number | US-201917252564-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 26, 2019 |
| Priority date | Jun 29, 2018 |
| Publication date | Sep 24, 2024 |
| Grant date | Sep 24, 2024 |
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Abstract
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A liquid composition comprising a polymer having pendant groups of the formula I: (I) Wherein X is either a bond or is a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S; and n is 1 to 4.
First claim
Opening claim text (preview).
The invention claimed is: 1. A liquid embolic composition suitable for therapeutic embolization, the composition comprising a polymer in solution in an organic solvent, the polymer comprising units of the formula 1: wherein X is either a bond or is a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S; wherein n is 1 to 4; wherein the polymer precipitates on contact with normal saline at 20° C.; wherein the precipitate has a radiodensity of at least 1000HU; and wherein the polymer is biodegradable. 2. A liquid embolic composition according to claim 1 wherein n is 1, 2 or 3. 3. A liquid embolic composition according to claim 1 wherein the polymer comprises units selected from 4. A liquid embolic composition according to claim 1 where X is selected from a bond, (C 1-4 )alkylene, (C 1-4 )oxyalkylene and amino(C 1-4 )alkylene. 5. A liquid embolic composition according to claim 1 where X is a bond. 6. A liquid embolic composition according to claim 1 wherein the polymer comprises units of the formula 3 7. A liquid embolic composition according to claim 1 comprising the polymer and a water-miscible solvent. 8. A liquid embolic composition according to claim 7 comprising between 3% and 70% wt/wt of the polymer dissolved in the water-miscible solvent. 9. A liquid embolic composition according to claim 7 wherein the water-miscible solvent is a polar aprotic solvent. 10. A liquid embolic composition according to claim 7 wherein the water-miscible solvent is selected from dimethylsulphoxide, dimethylformamide, N, N′-dimethylpropyleneurea, 1,3-dimethyl-2-imidazolidinone, glycerol, ethyl lactate, N-Methyl-2-pyrrolidone and 2-(Oxolan-2-ylmethoxy)ethanol. 11. A liquid embolic composition according to claim 1 wherein n is 2 or 3. 12. A liquid embolic composition according to claim 1 wherein the polymer comprises a polyvinyl alcohol copolymer. 13. A liquid embolic composition according to claim 1 wherein the polymer is non cross linked. 14. A liquid embolic composition according to claim 1 wherein the polymer comprises iodine in an amount of 10% or greater (w/w) based on a dried weight of the polymer.
Assignees
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Classifications
Polyvinyl alcohol {; Vinyl alcohol} · CPC title
liquid materials adapted to be injected · CPC title
Polyvinyl alcohol {; Vinyl alcohol} · CPC title
by a acetal or ketal radical · CPC title
Oxygen · CPC title
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- What does patent US12098220B2 cover?
- A liquid composition comprising a polymer having pendant groups of the formula I: (I) Wherein X is either a bond or is a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S; and n is 1 to 4.
- Who is the assignee on this patent?
- Biocompatibles Uk Ltd, Boston Scientific Medical Device Limited
- What technology area does this patent fall under?
- Primary CPC classification A61K49/0442. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 24 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).