Wireless iontophoresis patch and controller

Patent metadata

Field	Value
Publication number	US-12097367-B2
Application number	US-202217736602-A
Country	US
Kind code	B2
Filing date	May 4, 2022
Priority date	Jun 14, 2018
Publication date	Sep 24, 2024
Grant date	Sep 24, 2024

Abstract

An iontophoresis system for positioning against skin of a subject is disclosed. The iontophoresis system can comprise at least one vessel having a solvent therein. An anode apparatus can couple to the at least one vessel. The anode apparatus can comprise a first reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a first electrode positioned above the first reservoir. A cathode apparatus can couple to the at least one vessel. The cathode apparatus can comprise a second reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a second electrode positioned above the second reservoir.

First claim

What is claimed is:

1. A method for iontophoresis comprising:
securing an anode apparatus to the skin of the subject, the anode apparatus having a first reservoir configured to receive solvent so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a first electrode positioned above the first reservoir;
securing a cathode apparatus to the skin of the subject, the cathode apparatus having a second reservoir configured to receive the solvent so that, when received into the second reservoir, the solvent makes contact with the skin of the subject, and a second electrode positioned above the second reservoir;
discharging a solvent from at least one vessel, through a first tube, to mix with a first powdered agent and enter the anode apparatus;
discharging the solvent from the at least one vessel, through a second tube, to mix with a second powdered agent and enter the cathode apparatus; and
generating a therapeutic direct electrical pulse having a first charge that creates an electrical voltage difference between the first electrode and the second electrode to transport the charged therapeutic agent through the skin of the subject.

2. The method of claim 1 , further comprising generating a depolarizing electrical pulse by a depolarizer electrode in contact with the skin, the depolarizing electrical pulse having an electric charge opposite of an electric charge on the surface of the skin to depolarize the skin of the subject.

3. The method of claim 2 , wherein the depolarizer electrode is different from the first electrode and the second electrode.

4. The method of claim 1 , wherein the hair of the subject in the first position on the skin is epilated prior to securing the anode apparatus to the epilated area of the skin of the subject.

5. The method of claim 4 , wherein the hair of the subject is epilated by sugaring.

6. The method of claim 5 , further comprising epilating the skin by sugaring.

7. The method of claim 1 , wherein the first powdered agent is one of neostigmine, glycopyrrolate, fentanyl, alendronate, insulin, citric acid, lidocaine, vitamin B12, sumatriptan, or any other ionizable therapeutic substance.

8. The method of claim 1 , wherein a duration of the therapeutic electrical pulse is determined at least in part by settings of a controller device in communication with the first electrode and the second electrode.

9. The method of claim 1 , wherein discharging the solvent from the at least one vessel, through the first tube, to mix with the first powdered agent and enter the anode apparatus comprises discharging the solvent through a first conduit that extends between and is in communication with the at least one vessel and the first reservoir, wherein the first conduit permits communication of solvent between the at least one vessel and the first reservoir wherein the first conduit and the first reservoir cooperate to define a first solvent delivery pathway, wherein the first agent is disposed within the first solvent delivery pathway; and
wherein discharging the solvent from the at least one vessel, through the second tube, to mix with the second powdered agent and enter the cathode apparatus comprises discharging the solvent through a second conduit that extends between and is in communication with the at least one vessel and the second reservoir, wherein the second conduit permits communication of solvent between the at least one vessel and the second reservoir.

10. The method of claim 1 , further comprising:
removing, by a first negative pressure source in communication with the first reservoir, air from the first reservoir.

11. The method of claim 10 , wherein the first negative pressure source comprises a resilient compressible chamber, wherein removing the air from the first reservoir comprises removing the air from the first reservoir through a one-way valve positioned in fluid communication with the first negative pressure source and ambient air.

12. The method of claim 10 , wherein the first negative pressure source comprises a volume having a negative pressure trapped therein, wherein removing the air from the first reservoir comprises: piercing, with a needle, the volume having the negative pressure trapped therein; and
flowing the air between the needle and the volume having the negative pressure trapped therein through a third conduit.

13. The method of claim 10 , wherein the first negative pressure source comprises:
a syringe chamber,
a plunger movable within the syringe chamber, and
a check valve configured to allow fluid into the syringe chamber and inhibit fluid from exiting the syringe chamber.

14. The method of claim 1 , wherein a vertical spacer is disposed within the first reservoir.

15. The method of claim 9 , wherein the second conduit and the second reservoir cooperate to define a second solvent delivery pathway, wherein at least one additional powdered agent is disposed within the second solvent delivery pathway so that delivery of the solvent to the second reservoir causes mixing with the at least one powdered agent to form a second solution, wherein the at least one additional powdered agent comprises citric acid.

16. The method of claim 9 , wherein the second conduit and the second reservoir cooperate to define a second solvent delivery pathway, wherein at least one additional powdered agent is disposed within the second solvent delivery pathway disposed so that delivery of the solvent to the second reservoir causes mixing with the at least one powdered agent to form a second solution, wherein the at least one additional powdered agent comprises a di-protic or tri-protic acid.

17. The method of claim 16 , wherein the at least one powdered agent comprises a quantity of acid that, when mixed with the solvent to fill the anode reservoir, provides a concentration of the di-protic or tri-protic acid that is non-irritating to the skin.

18. The method of claim 17 , wherein the concentration ranges from 0.2% to 2%.

19. The method of claim 1 , the therapeutic direct electrical pulse is not conducted through any wires.

20. The method of claim 1 , further comprising inhibiting current flow, by an insulator bridge, between the first electrode and the second electrode.

Assignees

• Us Gov Veterans Affairs

Inventors

• Sabiev Anton
• Bauman William
• Korsten Mark

Classifications

• A61N1/0432

  Anode and cathode · CPC title

• A61N1/30 Primary

  Apparatus for iontophoresis, {i.e. transfer of media in ionic state by an electromotoric force into the body}, or cataphoresis · CPC title

• A61N1/0448 Primary

  Drug reservoir · CPC title