Bio-electrode for measuring bio-signal and producing electrical activity based on nano-porous permeable membrane having high specific surface area and method of manufacturing the same

Patent metadata

Field	Value
Publication number	US-12097308-B2
Application number	US-201816642822-A
Country	US
Kind code	B2
Filing date	Jun 19, 2018
Priority date	Jun 29, 2017
Publication date	Sep 24, 2024
Grant date	Sep 24, 2024

Abstract

The present invention relates to a bio-electrode having improved conductivity, flexibility and bio-compatibility, and a method of manufacturing the same. Specifically, the present invention relates to a conductive polymer bio-electrode including nano-porous permeable membrane, based on a bio-compatible polymer material having a plurality of pores and an improved surface area based on a PDMS device having a low mechanical strength and an excellent bio-compatibility, bio-signal transmission patterning, and a gold coating layer and has an excellent bio-compatibility and low rejection response while having a conductivity similar to that of a bio-electrode configured with a metal material of the related art. Therefore, the conductive polymer bio-electrode of the present invention is expected to be able to replace a bio-electrode configured with a metal material by which the bio-signal transmission efficiency is degraded due to a high bio-incompatibility.

First claim

The invention claimed is:

1. A conductive polymer bio-electrode comprising;
a polydimethylsiloxane (PDMS) device having an intaglio groove to which a nano-porous permeable membrane is to be attached and having a thickness of 250 to 350 μm;
the nano-porous permeable membrane having a thickness of 50 to 200 μm which is to be attached to the intaglio groove of the PDMS device;
a bio-signal transmission patterning formed on the PDMS device and the nano-porous permeable membrane; and
a gold (Au) coating layer which is uniformly formed with a thickness of 0.1 to 10 μm on the PDMS device, the nano-porous permeable membrane, and the bio-signal transmission patterning.

2. The conductive polymer bio-electrode according to claim 1 , wherein 25 to 50% of a total area of the PDMS device is an intaglio groove having a depth of 100 to 200 μm for attaching the nano-porous permeable membrane.

3. The conductive polymer bio-electrode according to claim 1 , wherein the nano-porous permeable membrane is a permeable membrane having a thickness of 50 to 200 μm manufactured by electrospinning a bio-compatible polymer material and includes a plurality of pores having a diameter of 0.1 to 10 μm.

4. The conductive polymer bio-electrode according to claim 3 , wherein the bio-compatible polymer material is any one or a mixture of two or more selected from a group consisting of polyurethane, polyacetal, polyamide, polyamide elastomer, polyester, polyester elastomer, polystyrene, polypropylene, polyacrylonitrile, polymethylmethacrylate, polyolefin, polysulfone, polyvinyl chloride, silicon, and polyethylene.

5. The conductive polymer bio-electrode according to claim 3 , wherein the electrospinning is performed by spinning 4 to 6 ml of the electrospinning solution containing the bio-compatible polymer material under conditions of a voltage of 10 to 20 kV, a spinning rate of 0.05 to 0.3 ml/h, a needle diameter of 20 to 30 G, and a spinning distance of 20 to 40 cm in an atmosphere of a humidity of 20 to 40% and a temperature of 25 to 35° C.

6. The conductive polymer bio-electrode according to claim 1 , wherein the nano-porous permeable membrane is capable of cell culture.

Assignees

• Knu—Industry Cooperation Found
• Knu Industry Cooperation Found

Inventors

• Lee Kwang Ho

Classifications

• A61B5/268

  containing conductive polymers, e.g. PEDOT:PSS polymers · CPC title

• A61B5/263

  characterised by the electrode materials · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title

• A61L2420/08

  Coatings comprising two or more layers · CPC title

• A61L31/10

  Macromolecular materials · CPC title