Microbiome identification and bacteriophage formulations
US-2024123002-A1 · Apr 18, 2024 · US
Methods and compositions for diagnosis of rickettsia infection
US12092640B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12092640-B2 |
| Application number | US-202017004309-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 27, 2020 |
| Priority date | Aug 27, 2019 |
| Publication date | Sep 17, 2024 |
| Grant date | Sep 17, 2024 |
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- Title
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Abstract
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Certain embodiments are directed to detection methods and methods of identifying detection targets for sensitive and specific laboratory tests to diagnose and monitor rickettsial infections during the earliest stages of the disease and to assess the degree of illness.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for detecting acute phase Rickettsial protein RC0497 in a sample comprising: contacting the sample with antibodies that bind Rickettsial protein RC0497 (SEQ ID NO:1) or Rickettsial protein RC0497 peptides forming an antibody complex with RC0497 peptides in the sample or RC0497 reactive antibodies in the sample, respectively; isolating the antibody complex; and identifying the peptides present in the antibody complex. 2. The method of claim 1 , wherein the peptides are HDLVGLGEVTVNR (SEQ ID NO:2), LLLSLDSTGEK (SEQ ID NO:3), ELAEAGFGR (SEQ ID NO:4), SDFPAEQIGK, (SEQ ID NO:5), EYHNDLTDQAFYAGK (SEQ ID NO:6), EYGYGVESTSTFDQFTQQAVR (SEQ ID NO:7), and/or GASVHYIIDK (SEQ ID NO:8). 3. The method of claim 1 , wherein the peptides are identified by selected reaction monitoring (SRM). 4. The method of claim 1 , wherein the antibody is a polyclonal antibody. 5. The method of claim 1 , wherein the Rickettsial protein RC0497 is a R. africae, R. conorii, or R. parkeri Rickettsial protein RC0497. 6. The method of claim 1 , further comprising detecting at least one host response protein selected from BPI fold-containing family A member 2, Histone H3.3, Ferritin heavy chain, 4-hydroxy-phenylpyruvate dioxygenase, or Adenylyl cyclase-associated protein 1.
Assignees
Inventors
Classifications
involving antibody fragments · CPC title
from Richettsiales (O) · CPC title
Rickettsiales (O) · CPC title
Antibacterial agents · CPC title
- G01N33/56911Primary
Bacteria · CPC title
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Frequently asked questions
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- What does patent US12092640B2 cover?
- Certain embodiments are directed to detection methods and methods of identifying detection targets for sensitive and specific laboratory tests to diagnose and monitor rickettsial infections during the earliest stages of the disease and to assess the degree of illness.
- Who is the assignee on this patent?
- Univ Texas
- What technology area does this patent fall under?
- Primary CPC classification G01N33/56911. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Sep 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).