US12091390B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12091390-B2 |
| Application number | US-201916442770-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 17, 2019 |
| Priority date | Feb 6, 2014 |
| Publication date | Sep 17, 2024 |
| Grant date | Sep 17, 2024 |
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An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
Opening claim text (preview).
The invention claimed is: 1. A production method of a compound represented by the following formula (1a): wherein R is a n-propyl group or an isopropyl group, comprising (iia) condensing a compound represented by the following formula (3): and a compound represented by the following formula (4a): wherein R 2 is a tert-butyl group, in the presence of a base to obtain a compound represented by the following formula (5): wherein R 2 is as defined for R 2 in said formula (4a); and (iib) reacting the compound represented by formula (5) with an alcohol represented by R—OH wherein R is a n-propyl group or an isopropyl group. 2. The production method of claim 1 , wherein R is the isopropyl group. 3. The production method of claim 1 , wherein R is the n-propyl group.
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