Device and system for injecting biological tissue

Patent metadata

Field	Value
Publication number	US-12090262-B2
Application number	US-202117464529-A
Country	US
Kind code	B2
Filing date	Sep 1, 2021
Priority date	Sep 1, 2021
Publication date	Sep 17, 2024
Grant date	Sep 17, 2024

Abstract

A device, kit, and method for aspirating graft tissue and delivering the graft tissue to a target delivery site. An injector comprises a cylinder and a plunger that is both linearly and rotatably advanceable and retractable within the cylinder. A kit comprises an injector, a cartridge, and a cartridge coupling element that connects the cartridge to the injector. The kit may also include a container that is configured to retain a cartridge and to facilitate connection between the injector and the cartridge. The container includes at least one fluid barrier that prevents spillage of storage solution from the container when the injector is at least partially inserted into the well of the container.

First claim

What is claimed is:

1. An injector kit, the injector kit comprising:
an injector including a body, the body including:
a first end having a first opening;
a second end opposite the first end, the second end having a second opening and an end wall at least partially defining the second opening;
a chamber extending from the first end to the second end, the chamber being in fluid communication with the first opening and the second opening, the chamber being at least partially defined by an inner surface of the body;
a stalk having a first end extending from the end wall of the second end of the body, a second end opposite the first end and having an opening, and a lumen therebetween, the lumen being in fluid communication with the chamber of the body of the injector and the opening of the second end of the stalk; and
a connection extension, the connection extension including a first end extending from the second end of the body, a second end opposite the first end, and an opening at least partially defined by the second end, and a chamber between the opening and the end wall of the second end of the body, the chamber of the connection extension having an inner surface, the stalk being located within the chamber of the connection extension, the stalk and the connection extension being coaxial, the inner surface of the chamber of the connection extension being without threading;

a cartridge coupling element, the cartridge coupling element having an external surface, the cartridge coupling element being removably engageable with the body of the injector and including:
a first portion including a friction fit element, at least a portion of the friction fit element being on the external surface of the cartridge coupling element, the friction fit element having an opening with a diameter, the friction fit element being sized and configured such that the portion of the friction fit element that is on the external surface of the cartridge coupling element is in contact with the inner surface of the connection extension when the cartridge coupling element is coupled to the injector, the friction fit element being removably couplable to the stalk of the body of the injector within the chamber of the connection extension solely by friction fit between the friction fit element and the inner surface of the chamber of the connection extension, the friction fit element being rotatable about an axis of the connection extension of the body of the injector within the connection extension when the cartridge coupling element is engaged with the body of the injector and the injector is in use, the friction fit element being composed of a resiliently compressible material; and
a second portion opposite the first portion, the second portion including a collar; and

a tissue cartridge, the collar of the cartridge coupling element being removably and securely engageable with the tissue cartridge to couple the tissue cartridge to the body of the injector.

2. The injector kit of claim 1 , wherein the tissue cartridge includes:
a first portion defining a first opening;
a second portion defining a second opening, the second opening being opposite the first opening; and
a chamber between and in fluid communication with the first opening of the tissue cartridge and the second opening of the tissue cartridge,
the collar of the cartridge coupling element being removably engageable with the first portion of the tissue cartridge.

3. The injector kit of claim 2 , wherein the collar of the cartridge coupling element is removably engageable with the first portion of the tissue cartridge by a luer lock.

4. The injector kit of claim 2 , wherein an outer surface of the first portion of the tissue cartridge includes a first luer lock component and an inner surface of the collar includes a second luer lock component, the first and second luer lock components being matably engageable with each other to prevent a fluid from leaking between the tissue cartridge and cartridge coupling element.

5. The injector kit of claim 2 , wherein:
the friction fit element is sized and configured to be at least partially received within and to fit in close tolerance within the chamber of the connection extension of the body of the injector;
the stalk of the body of the injector has an outer diameter that is slightly smaller than the diameter of the opening of the friction fit element, such that the stalk is removably insertable within the opening of the friction fit element and securable therein by friction fit when the friction fit element is at least partially received within the chamber of the connection extension; and
the opening of the stalk of the body of the injector has an inner diameter that is slightly larger than the outer diameter of the second portion of the tissue cartridge, such that the second portion of the tissue cartridge is removably insertable within the opening of the stalk and securable therein by friction fit when the cartridge coupling element is disengaged from the stalk.

6. The injector kit of claim 2 , wherein the stalk of the body of the injector is sized and configured to be at least partially inserted into the first opening of the tissue cartridge.

7. The injector kit of claim 1 , wherein at least a portion of the inner surface of the body of the injector defines a threading, the injector kit further comprising a plunger, the plunger including:
a shaft having a first portion and a second portion opposite the first portion, the second portion having a free end; and
a knob coupled to the first portion,
an outer surface of at least a portion of the first portion defining a protrusion, the protrusion being located a distance from the knob and being sized and configured to rotatably engage with the threading of the body,
the plunger being rotatably advanceable and linearly advanceable within the body and rotatably retractable and linearly retractable within the body.

8. The injector kit of claim 1 , wherein the body has a first longitudinal axis and the connection extension has a second longitudinal axis that is different than the first longitudinal axis, the second longitudinal axis being oriented at an angle from the first longitudinal axis.

9. The injector kit of claim 8 , wherein the angle is less than approximately 90°.

10. The injector kit of claim 8 , wherein the angle is between approximately 22.5° and approximately 67.5°.

11. The injector kit of claim 1 , further comprising a container, the container including:
a base, the base having an upper face and a well, the well being configured to contain a volume of liquid, the well including a first portion and at least one second portion extending away from the first portion, a first end of the first portion being sized and configured to retain the tissue cartridge and a second end of the first portion having a ramp, the ramp being sloped downward toward the first end of the first portion and configured to guide the body of the injector toward the tissue cartridge when the tissue cartridge is retained within the first end of the first portion; and
a lid that is removably couplable to the base.

12. The injector kit of claim 11 , wherein the upper face includes:
a first fluid barrier surrounding the well; and
a second fluid barrier surrounding and being a distance from the first fluid barrier, the well and the first fluid barrier being configured to contain a first volume of solution, and the first fluid barrier and the second fluid barrier being configured to contain a second volume of solution therebetween, the second volume of solution being less than the first volume of solution.

13. The injector kit of claim 12 ,

Assignees

• Tissuecor Llc
• Univ Miami

Inventors

• Sabater Alfonso L
• Buras William B
• Sabater Alejandro M
• Duminuco Daniel J
• Botta Michael A

Classifications

• A61M2210/0612

  Eyes · CPC title

• A61M1/87

  Details of the aspiration tip, not otherwise provided for · CPC title

• A61F9/0017

  implantable in, or in contact with, the eye, e.g. ocular inserts · CPC title

• A61F2/0095

  Packages or dispensers for prostheses or other implants (for intraocular lenses A61F2/1691; for dental surgery A61C19/02) · CPC title

• A61M1/842 Primary

  rotating (continuously rotating surgical cutting instruments A61B17/32002) · CPC title