Implant and coating to reduce osteolysis

Patent metadata

Field	Value
Publication number	US-12090249-B2
Application number	US-202117202527-A
Country	US
Kind code	B2
Filing date	Mar 16, 2021
Priority date	Oct 6, 2015
Publication date	Sep 17, 2024
Grant date	Sep 17, 2024

Abstract

An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

First claim

What is claimed is:

1. A method for forming a coating comprising steps of:
providing a substrate; and
electrophoretically forming the coating on at least a portion of the substrate using a dispersion;
wherein the dispersion comprises ceria nanoparticles with cerium predominantly in a Ce 3+ oxidation state on the surface thereof (NC1) or the ceria nanoparticles with cerium predominantly in a higher Ce 4+ oxidation state on the surface thereof (NC2), or a mixture of NC1 and NC2;
wherein NC1 and NC2 comprise the ceria nanoparticles having a size in a range of 3-5 nm; and
wherein the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both.

2. The method of claim 1 , wherein the electrophoretic forming step is carried out by applying a voltage having a DC component and/or an AC component to the substrate and at least one counter-electrode, wherein the voltage is continuous, pulsed, or arbitrarily increasing or decreasing with time.

3. The method of claim 2 , wherein the at least one counter-electrode comprises two counter-electrodes.

4. The method of claim 1 , further comprising after the coating has been formed, heating the substrate to 200-450° C. for 1-2.5 hr.

5. The method as recited in claim 1 , wherein one electrode is a Ti electrode and two electrodes are nonconsumable counter-electrodes.

6. The method of claim 1 , wherein the substrate comprises a prosthesis.

Assignees

• Univ Central Florida Res Found Inc
• Sanford Burnham Prebys Medical Discovery Inst

Inventors

• Seal Sudipta
• Das Soumen
• Self William
• Towler Dwight

Classifications

• A61L2430/24

  for joint reconstruction · CPC title

• A61L2420/02

  Methods for coating medical devices · CPC title

• A61L2300/102

  Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61L27/14

  Macromolecular materials · CPC title