Measuring responses to sound using pupillometry

Patent metadata

Field	Value
Publication number	US-12089937-B2
Application number	US-202318136223-A
Country	US
Kind code	B2
Filing date	Apr 18, 2023
Priority date	Feb 7, 2019
Publication date	Sep 17, 2024
Grant date	Sep 17, 2024

Abstract

A method and apparatus is disclosed for testing hearing in infants based on pupil dilation response. It does not require sedation or depend on subjective judgments of human testers. Pupil dilation response to sound is measured by presenting on a display a visually engaging video containing periodic changes; presenting sounds synchronized with the periodic changes of the video; recording images from a camera directed in front of the display, where the camera is sensitive to infrared wavelengths; processing the images to measure pupil sizes; and processing the measured pupil sizes to determine, statistically, the presence of a pupil dilation response to the sounds.

First claim

The invention claimed is:

1. A device for measuring pupil dilation response to sound, the device comprising an infrared sensitive camera, a speaker, a display, and a computer, wherein the device is configured to present on the display to a subject a visually engaging video containing an animation having periodic changes; present to the subject sounds at regular intervals in phase with the periodic changes of the animation; record images from the camera directed toward eyes of the subject; process the images to measure pupil sizes of the eyes by extracting major and minor axes of a pupil in each of the images and adjusting pupil size and shape to compensate for head and eye movements; and process the measured pupil sizes to determine, statistically, the presence of a pupil dilation response to the sounds.

2. The device of claim 1 wherein the visually engaging video is selected to have sufficiently constant luminance to avoid pupil responses to luminance changes.

3. The device of claim 1 wherein the visually engaging video is selected to be sufficiently engaging such that a child's gaze remains focused on the animation during a majority of a predetermined examination time.

4. The device of claim 1 wherein the visually engaging video includes periodic patterns sufficiently repetitive to cause habituation.

5. The device of claim 1 wherein the sounds are selected to cause a pupil dilation response without causing a startle response.

6. A device for measuring pupil dilation response to sound, the device comprising a camera, a speaker, a display, and a computer, wherein the device is configured to present on the display to a subject a video containing an animation having periodic changes; present to the subject sounds at regular intervals in phase with the periodic changes of the animation; record images from the camera directed toward eyes of the subject; process the images to measure pupil sizes of the eyes by extracting major and minor axes of a pupil in each of the images; and process the measured pupil sizes to determine, statistically, the presence of a pupil dilation response to the sounds; wherein the device is configured to adjust the measured pupil size to compensate for head and eye movements.

Assignees

• Univ Oregon

Inventors

• Bala Singh Avinash Deep
• Takeshi Takahashi Terry

Classifications

• A61B5/742

  using visual displays (displays for heart-related electrical signals, e.g. ECG, A61B5/339) · CPC title

• A61B3/112 Primary

  for measuring diameter of pupils · CPC title

• A61B2503/04

  Babies, e.g. for SIDS detection · CPC title

• A61B3/14

  Arrangements specially adapted for eye photography · CPC title

• A61B5/7405

  using sound · CPC title