Measurement device and measurement system

Patent metadata

Field	Value
Publication number	US-12085455-B2
Application number	US-201917250520-A
Country	US
Kind code	B2
Filing date	Aug 6, 2019
Priority date	Aug 8, 2018
Publication date	Sep 10, 2024
Grant date	Sep 10, 2024

Abstract

In a device that measures biopotentials of cells in a solution, the solution is controlled at a constant temperature. A measurement device includes a substrate, a sensing control circuit, a temperature sensor, a front surface side heat radiating unit, a back surface side heat radiating unit, and a temperature control unit. A plurality of electrodes each detecting a potential in the solution is arranged on the front surface of the substrate. The sensing control circuit is arranged on the substrate and controls detection of potentials at the plurality of electrodes. The temperature sensor is arranged on the substrate and detects a temperature of the solution. The front surface side heat radiating unit is arranged on the front surface side of the substrate and radiates heat. The back surface side heat radiating unit is arranged on the back surface side that is a surface different from the front surface of the substrate, and radiates heat. The temperature control unit controls the temperature of the solution on the basis of the temperature detected by the temperature sensor.

First claim

The invention claimed is:

1. A measurement device, comprising:
a substrate;
a plurality of electrodes on a front surface of the substrate, wherein
each electrode of the plurality of electrodes is configured to detect a potential in a solution;

a sensing control circuit, on the substrate, configured to control the detection of the potential by each electrode of the plurality of electrodes;
a first temperature sensor, on the substrate, configured to detect a first temperature of the solution;
a front surface side heat radiating unit, on a front surface side of the substrate, wherein the front surface side heat radiating unit is configured to radiate heat of the substrate;
a back surface side heat radiating unit, on a back surface side of the substrate, wherein
the back surface side heat radiating unit is configured to radiate the heat, and
the back surface side of the substrate is different from the front surface of the substrate;

a temperature control unit configured to control a temperature of the solution based on the first temperature detected by the first temperature sensor;
a temperature adjustment unit configured to absorb the heat and radiate the heat to adjust the temperature of the solution based on the control by the temperature control unit; and
a shielding unit, between the temperature adjustment unit and the substrate, wherein the shielding unit is configured to shield at least one component of the measurement device from the heat radiation from the temperature adjustment unit.

2. The measurement device according to claim 1 , further comprising a reservoir unit configured to store the solution.

3. The measurement device according to claim 1 , wherein the temperature control unit is further configured to control the temperature of the solution based on the adjustment of the temperature the temperature adjustment unit.

4. The measurement device according to claim 3 , wherein the temperature adjustment unit is further configured to adjust the temperature via at least one of the front surface side heat radiating unit or the back surface side heat radiating unit.

5. The measurement device according to claim 4 , wherein
the temperature adjustment unit includes a Peltier element, and
the temperature adjustment unit is further configured to adjust temperature by the Peltier element.

6. The measurement device according to claim 5 , wherein the temperature adjustment unit further includes a cooling unit that is configured to cool the Peltier element.

7. The measurement device according to claim 6 , wherein the cooling unit is further configured to cool the Peltier element based on circulation of cooling water.

8. The measurement device according to claim 1 , wherein the front surface side heat radiating unit includes a metal.

9. The measurement device according to claim 8 , wherein
the front surface side heat radiating unit is further configured to connect to a ground line that supplies a ground potential, and
the ground potential serves as a reference potential for the sensing control circuit for the detection of the potential.

10. The measurement device according to claim 1 , wherein the back surface side heat radiating unit includes a metal.

11. The measurement device according to claim 10 , wherein the back surface side heat radiating unit is further configured to connect to a ground line that supplies a ground potential, and
the ground potential serves as a reference potential for the sensing control circuit for the detection of the potential.

12. The measurement device according to claim 1 , wherein the shielding unit is further configured to connect to a ground line.

13. The measurement device according to claim 12 , wherein the ground line supplies a ground potential that serves as a reference potential for the sensing control circuit for the detection of the potential.

14. The measurement device according to claim 1 , further comprising a sensing region which includes;
a plurality of electrode cells, wherein
each electrode cell of the plurality of the electrode cells includes an electrode of the plurality of electrodes; and

an amplifier circuit configured to amplify the potential detected by the electrode of the plurality of electrodes.

15. The measurement device according to claim 1 , further comprising a reference electrode configured to apply a reference potential that serves as a reference for the potential to the solution.

16. The measurement device according to claim 1 , further comprising:
a plurality of temperature sensors on the substrate, wherein the plurality of temperature sensors include the first temperature sensor,
the plurality of temperature sensors are configured to detect a plurality of temperatures of the solution respectively, and
the temperature control unit is further configured to control the temperature of the solution based on the plurality of temperatures detected by the plurality of temperature sensors.

17. The measurement device according to claim 1 , further comprising:
a second temperature sensor at a specific position which is different from a position on the substrate, wherein
the second temperature sensor is configured to detect a second temperature of the solution, and
the temperature control unit is further configured to control the temperature of the solution based on the first temperature detected by the first temperature sensor and the second temperature detected by the second temperature sensor.

18. A measurement system, comprising:
a substrate;
a plurality of electrodes on a front surface of the substrate, wherein
each electrode of the plurality of electrodes is configured to detect a potential in a solution;

a sensing control circuit, on the substrate, wherein the sensing control circuit is configured to control the detection of the potential by each electrode of the plurality of electrodes;
a temperature sensor, arranged on the substrate, configured to detect a temperature of the solution;
a front surface side heat radiating unit, on a front surface side of the substrate, configured to radiate heat of the substrate;
a back surface side heat radiating unit, on a back surface side of the substrate, configured to radiate the heat, wherein the back surface side of the substrate is different from the front surface of the substrate;
a temperature control unit configured to control the temperature of the solution based on the temperature detected by the temperature sensor;
a temperature adjustment unit configured to absorb the heat and radiate the heat to adjust the temperature of the solution based on the control by the temperature control unit;
a shielding unit, between the temperature adjustment unit and the substrate, wherein the a shielding unit is configured to shield at least one component of the measurement system from the heat radiation from the temperature adjustment unit; and
a processing circuit that is configured to process the detected potential.

19. A measurement device, comprising:
a substrate;
a plurality of electrodes on a front surface of the substrate, wherein
each electrode of the plurality of electrodes is configured to detect a potential in a solution;

a sensing control circuit, on the substrate, configured to control the detection of the potential by each electrode of the plurality of electrodes;
a temperature sensor, on the substrate, configured to detect a temperature of the solution;
a front surface side heat radiating unit, on a front surface side of the substrate, configured to radiate heat of

Assignees

• Sony Semiconductor Solutions Corp

Inventors

• Maehara Masataka

Classifications

• G01N33/48742

  Determining urea by measuring the volume of a gas (in general G01N7/14 - G01N7/18) · CPC title

• B01L7/04

  Heat insulating devices, e.g. jackets for flasks · CPC title

• B01L3/50851

  specially adapted for heating or cooling samples · CPC title

• H10N10/10 Primary

  operating with only the Peltier or Seebeck effects · CPC title

• G05D23/20

  with sensing elements having variation of electric or magnetic properties with change of temperature (G05D23/13 takes precedence) · CPC title