Alignment of a disposable for a spray drying plasma system

Patent metadata

Field	Value
Publication number	US-12083447-B2
Application number	US-202217945130-A
Country	US
Kind code	B2
Filing date	Sep 15, 2022
Priority date	Sep 15, 2022
Publication date	Sep 10, 2024
Grant date	Sep 10, 2024

Abstract

An alignment system that allows a spray drying disposable to align in both spray drying apparatus and finishing apparatus. The first instance is a locating arrangement wherein a locator is disposed on the spray drying apparatus and/or finishing apparatus and another locator is on the spray drying head of the disposable such that the locators allow for alignment of the disposable with the spray drying apparatus or finishing apparatus. A second instance of an alignment element includes a guide that is offset as positioned on the spray drying head of the disposable. Yet a third instance of the alignment arrangement relates to the gas exhaust port. In a fourth instance, the alignment system includes a positioning arrangement to reversibly attach the outer wall of the disposable to the finishing apparatus. In a fifth and sixth instance, a retaining device that retains the spray drying head in the spray drying apparatus and/or finishing apparatus.

First claim

What is claimed is:

1. A spray drying system having a spray drying apparatus, a spray drying disposable device, and a spray drying finishing apparatus, said spray drying system comprises:
A) the spray drying apparatus for spray drying plasma comprising:
i) a plasma source providing a plasma;
ii) a pressurized aerosol gas source providing a pressurized aerosol gas;
iii) a drying gas source providing a drying gas;
iv) a receiver for receiving a guide on the spray drying disposable device;
v) a locating arrangement for aligning the spray drying disposable device, said locating arrangement having a first locator; a second locator and a third locator, wherein the first locator is at the spray drying apparatus;
vi) a first retaining clip; and
vii) an exhaust port, opposite the drying gas source;

B) the spray drying disposable device having an outer edge, comprising:
i) A spray drying head comprising:
(1) a spray dry nozzle in fluid communication with the plasma source and the pressurized aerosol gas source;
(2) a drying gas inlet in communication with the drying gas source;
(3) the guide that is offset from the center of the spray drying head to allow said drying gas inlet to align with the drying gas source; and
(4) the second locator in the spray drying head; wherein the second locator aligns with the first locator; and

ii) one or more first positioning arrangements at the outer edge of the spray drying disposable device for reversable attachment to the spray drying finishing apparatus;
iii) a drying chamber in fluid communication with the spray dry nozzle and the drying gas source to receive atomized plasma from the nozzle for drying; wherein the drying chamber has a top end and a bottom end, and
iv) a gas outlet, wherein when in use, is attached to the exhaust port of the spray drying apparatus;

C) the spray drying finishing apparatus having a top end and a bottom end, comprising:
i) an frame suspended by a shuttle, the frame comprises:
(1) a spray drying head receiver;
(2) the third locator, wherein the third locator aligns with the second locator of the spray drying head;
(3) one or more second positioning arrangements for receiving the first positioning arrangements at the outer edge of the spray drying disposable device; and
(4) a gas outlet receiver;

ii) an impactor, when in use and when the spray drying disposable device having spray dried plasma is attached, allows for the movement of the spray dry powder within the drying chamber,
iii) a sealer that seals the spray dried plasma within a portion of the drying chamber to thereby create a plasma bag; and
iv) a separator which separates the plasma bag from the drying chamber;

wherein when the receiver receives the guide on the spray drying disposable device, the first locator of the locating arrangement is aligned with the second locator of the spray drying head, and the first retaining clip engages the spray drying head, the spray drying apparatus and the spray drying disposable device are in an aligned position, and wherein when the third locator of the locating arrangement of the spray drying finishing apparatus is aligned with the second locator of the spray drying head, the gas outlet receiver of the spray drying finishing apparatus receives the gas outlet of the spray drying disposable device, and the one or more second positioning arrangements receives the first positioning arrangements of the outer edge of the spray drying disposable device, the spray drying finishing apparatus and spray drying disposable device are in an aligned position.

2. The spray drying system of claim 1 , wherein said second locator attaches, fits, complements or communicates with the first locator, the third locator or both.

3. The spray drying system of claim 1 , wherein the locating arrangement comprises a recess/projection arrangement, a complementing shape arrangement, a hook/receiver arrangement, a channel and groove arrangement, a latch and catch arrangement, or a combination thereof.

4. The spray drying system of claim 1 , wherein attachment of the drying gas outlet of the spray drying disposable device to the exhaust port of the spray drying apparatus further aligns the spray drying disposable device with the spray drying apparatus during use.

5. The spray drying system of claim 1 , wherein the one or more first positioning arrangements and the one or more second positioning arrangements comprises a pin and opening arrangement, a hook/receiver arrangement, channel and groove arrangement, a latch and catch arrangement or a combination thereof.

6. A spray drying system having a spray drying apparatus and a spray drying disposable device, wherein said spray drying system comprises:
A) the spray drying apparatus for spray drying plasma comprising:
i) a plasma source providing a plasma;
ii) a pressurized aerosol gas source providing a pressurized aerosol gas;
iii) a drying gas source providing a drying gas;
iv) a receiver for receiving a guide on the spray drying disposable device;
v) a locating arrangement for aligning the spray drying disposable device, said locating arrangement having a first locator at the spray drying apparatus;
vi) a groove; and
vii) a retaining clip; and

B) the spray drying disposable device comprising
i) A spray drying head comprising:
(1) a spray dry nozzle in fluid communication with the plasma source and the pressurized aerosol gas source;
(2) a drying gas inlet in communication with the drying gas source;
(3) the guide that is offset from the center of the spray drying head to allow said drying gas inlet to align with the drying gas source;
(4) a ridge; and
(5) a second locator in the spray drying head; wherein the second locator aligns with the locating arrangement having a first locator; and

ii) a drying chamber in fluid communication with the spray dry nozzle and the drying gas source to receive atomized plasma from the nozzle for drying;

wherein when the receiver receives the guide on the spray drying disposable device, the first locator of the locating arrangement is aligned with the second locator of the spray drying head, the groove receives the ridge, and the retaining clip engages the spray drying head, the spray drying apparatus and the spray drying disposable device are in an aligned position.

7. The spray dry system of claim 6 , wherein the locating arrangement for aligning the spray drying disposable device comprises an indicator to communicate that the spray drying disposable device is aligned.

8. The spray dry system of claim 7 , wherein the indicator is an audible indicator or a visual indicator.

9. The spray dry system of claim 6 , wherein the locating arrangement comprises a recess/projection arrangement, a complementing shape arrangement, a hook/receiver arrangement, a channel and groove arrangement, a latch and catch arrangement, or a combination thereof.

10. The spray drying system of claim 1 , wherein the spray drying head further comprises a ridge, and the spray drying apparatus further comprises a groove; wherein
when in use and the groove receives the ridge, the spray drying apparatus and the spray drying disposable device are in an aligned position.

11. The spray drying system of claim 10 , wherein when in use and the first retaining clip engages the groove, the spray drying apparatus and the spray drying disposable device are in an aligned position.

12. The spray drying system of claim 1 , wherein the spray drying finishing apparatus further comprises a second retaining clip, wherein when in use the second retaining clip engages the spray drying head.

13. The spray drying system of claim 6 , where

Assignees

• Velico Medical Inc

Inventors

• Andrews Robert R
• Snyder Herman E
• Merritt William J
• Erickson Kyle D
• Ordway Evan P
• Strohl Clair
• Barron Russell

Classifications

• F26B21/50

  Ducting arrangements from the source of air or other gases to the materials or objects being dried · CPC title

• F26B25/066

  Movable chambers, e.g. collapsible, demountable (self-contained mobile devices, e.g. for agricultural produce F26B19/005) · CPC title

• B01D1/18 Primary

  to obtain dry solids (B01D1/24 takes precedence) · CPC title

• F26B3/12 Primary

  in the form of a spray {, i.e. sprayed or dispersed emulsions or suspensions (spray drying of solutions B01D1/18)} · CPC title