Botanical extracts and compounds from Schinus plants and methods of use

Patent metadata

Field	Value
Publication number	US-12083132-B1
Application number	US-202318121280-A
Country	US
Kind code	B1
Filing date	Mar 14, 2023
Priority date	Jul 10, 2015
Publication date	Sep 10, 2024
Grant date	Sep 10, 2024

Abstract

This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.

First claim

The invention claimed is:

1. A pharmaceutical formulation comprising:
(a) a therapeutically effective amount of a compound of the formula below

or a salt thereof, and
(b) a pharmaceutically acceptable excipient.

2. The pharmaceutical formulation of claim 1 , wherein the formulation is a particle, bead, tablet, capsule, or pill.

3. The pharmaceutical formulation of claim 1 , wherein the formulation is a lotion, liquid, or gel.

4. The pharmaceutical formulation of claim 1 , wherein the formulation further comprises an additional antibiotic.

5. The pharmaceutical formulation of claim 1 , wherein the formulation further comprises a steroid.

6. The pharmaceutical formulation of claim 1 , wherein the formulation further comprises an anti-inflammatory agent.

7. A method of treating or preventing a bacterial infection in a subject comprising administering to the subject an effective amount of a pharmaceutical formulation comprising:
(a) a therapeutically effective amount of a compound of the formula below

or a salt thereof, and
(b) a pharmaceutically acceptable excipient.

8. The method of claim 7 , wherein the subject has an abscess, furuncle, cellulitis, folliculitis, atopic dermatitis, psoriasis, impetigo, septic arthritis, brain abscess, burn wound, venous ulcer, diabetic foot ulcer, surgical wound, carbuncle, or meningitis.

9. The method of claim 7 , wherein the subject has bacteremia, pneumonia, staphylococcal food poisoning, necrotizing pneumonia, necrotizing fasciitis, scaled skin syndrome, post-operation bacterial infection, medical device bacterial infection, bacterial infection of the skin, soft tissue bacterial infection, or toxic shock syndrome.

10. The method of claim 7 , wherein the bacterial infection is a toxin-mediated bacterial infection.

11. The method of claim 10 , wherein the toxin-mediated bacterial infection is a Staphylococcus -mediated bacterial infection.

12. The method of claim 7 , wherein administering comprises topical administration of the formulation.

13. The method of claim 7 , further comprising administering to the subject an additional antibiotic.

14. The method of claim 13 , wherein the formulation further comprises an additional antibiotic.

15. The method of claim 7 , further comprising administering to the subject a steroid.

16. The method of claim 15 , wherein the formulation further comprises a steroid.

17. The method of claim 7 , further comprising administering to the subject an anti-inflammatory agent.

18. The method of claim 17 , wherein the formulation further comprises an anti-inflammatory agent.

Assignees

• Univ Emory

Inventors

• Quave Cassandra L
• Lyles James
• Porras-Brenes Gina
• Tang huaqiao

Classifications

• A61K31/575 Primary

  substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol · CPC title

• A61K36/22

  Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title