Kras g12c inhibitors and methods of using the same
US-2020030324-A1 · Jan 30, 2020 · US
Substituted piperazines as KRAS G12C inhibitors
US12083121B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12083121-B2 |
| Application number | US-202217579359-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 19, 2022 |
| Priority date | Jun 12, 2018 |
| Publication date | Sep 10, 2024 |
| Grant date | Sep 10, 2024 |
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- Title
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- Abstract
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- Assignees and inventors
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Abstract
Official abstract text for this publication.
Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for inhibiting KRAS G12C activity in a subject in need thereof, wherein the method comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of:
Assignees
Inventors
- Allen John Gordon
- Lanman Brian Alan
- Chen Jian
- Reed Anthony B
- Cee Victor J
- Liu Longbin
- Lopez Patricia
- Wurz Ryan Paul
- Nguyen Thomas T
- Booker Shon
- Allen Jennifer Rebecca
- Chu-Moyer Margaret
- Amegadzie Albert
- Chen Ning
- Goodman Clifford
- Low Jonathan D
- Ma Vu Van
- Minatti Ana Elena
- Nishimura Nobuko
- Pickrell Alexander J
- Wang Hui-Ling
- Shin Youngsook
- Siegmund Aaron C
- Yang Kevin C
- Tamayo Nuria A
- Walton Mary
- Xue Qiufen
Classifications
Antineoplastic agents · CPC title
against tumor tissues, cells, antigens · CPC title
having two nitrogen atoms, e.g. dilazep · CPC title
Bridged systems · CPC title
Bridged systems · CPC title
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US12083121B2 cover?
- Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
- Who is the assignee on this patent?
- Amgen Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/519. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).