Lumen morphology and vascular resistance measurements data collection systems apparatus and methods

Patent metadata

Field	Value
Publication number	US-12082912-B2
Application number	US-202117508484-A
Country	US
Kind code	B2
Filing date	Oct 22, 2021
Priority date	Sep 23, 2009
Publication date	Sep 10, 2024
Grant date	Sep 10, 2024

Abstract

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

First claim

The invention claimed is:

1. A method for identifying treatment options for stenotic lesions within a vessel, comprising:
receiving, by one or more processors, vessel image data;
generating, by the one or more processors, a resistance-based or computational fluid dynamic model of blood flow resistance within the vessel based on the vessel image data;
calculating, by the one or more processors, one or more predicted hemodynamic values based on the resistance-based or computational fluid dynamic model;
identifying, by the one or more processors, one or more stenotic lesions based on the resistance-based or computational fluid dynamic model;
identifying, by the one or more processors, a plurality of virtual stenting configurations based on user input;
re-calculating, by the one or more processors, the one or more predicted hemodynamic values as simulated predicted hemodynamic values in connection with simulating the plurality of virtual stenting configurations; and
providing for display, by the one or more processors, a representation of the vessel with the one or more simulated predicted hemodynamic values in connection with a selected virtual stenting configuration from the plurality of virtual stent configurations.

2. The method of claim 1 further comprising identifying, by the one or more processors, at least one of the plurality of virtual stenting configurations is further based on one or more stenting parameters.

3. The method of claim 1 , wherein identifying the one or more stenotic lesions comprises analyzing hemodynamic values based on the resistance-based or computational fluid dynamic model.

4. The method of claim 2 , wherein at least one stenting parameter is based on optimizing at least one of a predicted vascular resistance ratio or a predicted fractional flow reserve.

5. The method of claim 2 , wherein at least one stenting parameter is based on identifying a degree of stent overlap with one or more side branches.

6. The method of claim 1 , further comprising generating, by the one or processors, a lumen contour model based on the vessel image data.

7. The method of claim 6 , wherein re-calculating the one or more predicted hemodynamic values is performed without modifying the lumen contour model.

8. The method of claim 6 , wherein the lumen contour model comprises a 3D model of the vessel.

9. The method of claim 6 , further comprising modifying, by the one or more processors, the lumen contour model based on the one or more stents, and wherein recalculating the one or more simulated predicted hemodynamic values is based on the modified lumen contour model.

10. The method of claim 1 , wherein the plurality of virtual stenting configurations vary from one another in at least one of expanded diameter, stent length, and longitudinal position within the vessel.

11. A system for identifying treatment options for stenotic lesions within a vessel, comprising:
memory;
one or more processors in communication the memory, the one or more processors configured to:
receive vessel image data;
generate a resistance-based or computational fluid dynamic model of blood flow resistance within the vessel based on the vessel image data;
calculate one or more predicted hemodynamic values based on the resistance-based or computational fluid dynamic model;
identify one or more stenotic lesions based on the resistance-based or computational fluid dynamic model;

identifying a plurality of virtual stenting configurations based on user input;
re-calculate the one or more predicted hemodynamic values as simulated predicted hemodynamic values in connection with simulating the plurality of virtual stenting configurations; and
provide for display a representation of the vessel with the one or more simulated predicted hemodynamic values in connection with a selected virtual stenting configuration from the plurality of virtual stent configurations.

12. The system of claim 11 , wherein the one or more processors are further configured to identify the plurality of stenting configurations based on one or more stenting parameters.

13. The system of claim 11 , wherein identifying the one or more stenotic lesions comprises analyzing hemodynamic values based on the resistance-based or computational fluid dynamic model.

14. The system of claim 12 , wherein at least one stenting parameter is based on optimizing at least one of a predicted vascular resistance ratio or a predicted fractional flow reserve.

15. The system of claim 12 , wherein at least one stenting parameter is based on identifying a degree of stent overlap with one or more side branches.

16. The system of claim 11 , wherein the one or more processors are further configured to generate a lumen contour model based on the vessel image data.

17. The system of claim 16 , wherein calculating the one or more predicted hemodynamic values is performed without modifying the lumen contour model.

18. The system of claim 16 , wherein the lumen contour model comprises a 3D model of the vessel.

19. The system of claim 16 , wherein the one or more processors are further configured to modify the lumen contour model based on one or more stents, and wherein recalculating the one or more simulated predicted hemodynamic values is based on the modified lumen contour model.

20. A non-transitory computer-readable medium storing instructions executable by one or more processors for performing a method of identifying treatment options for stenotic lesions within a vessel, comprising:
receiving vessel image data;
generating a resistance-based or computational fluid dynamic model of blood flow resistance within the vessel based on the vessel image data;
calculating one or more predicted hemodynamic values based on the resistance-based or computational fluid dynamic model;
identifying one or more stenotic lesions based on the resistance-based or computational fluid dynamic model;
identifying a plurality of virtual stenting configurations based on user input;
re-calculating the one or more predicted hemodynamic values as simulated predicted hemodynamic values in connection with simulating the plurality of virtual stenting configurations; and
providing for display a representation of the vessel with the one or more simulated predicted hemodynamic values in connection with a selected virtual stenting configuration from the plurality of virtual stent configurations.

Assignees

• Lightlab Imaging Inc

Inventors

• Schmitt Joseph M
• Friedman Joel M
• Petroff Christopher
• Elbasiony Amr

Classifications

• A61B5/0073

  by tomography, i.e. reconstruction of 3D images from 2D projections (A61B5/0066 takes precedence) · CPC title

• A61B5/0066

  Optical coherence imaging · CPC title

• A61B5/0084

  for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence) · CPC title

• A61B5/02007 Primary

  Evaluating blood vessel condition, e.g. elasticity, compliance · CPC title