Injector serving multiple sample separation apparatuses

Patent metadata

Field	Value
Publication number	US-12078619-B2
Application number	US-201817288478-A
Country	US
Kind code	B2
Filing date	Oct 26, 2018
Priority date	Oct 26, 2018
Publication date	Sep 3, 2024
Grant date	Sep 3, 2024

Abstract

An injector, for injecting a fluidic sample in at least one selected one of a first sample separation apparatus and a second sample separation apparatus, includes a valve arrangement fluidically connectable to the first sample separation apparatus and the second sample separation apparatus, a sample accommodation volume for accommodating the fluidic sample, and a control unit configured for controlling the valve arrangement so that fluidic sample in the sample accommodation volume is selectively injectable into the selected first sample separation apparatus and/or second sample separation apparatus.

First claim

The invention claimed is:

1. An injector for injecting a fluidic sample into at least one selected one of a first sample separation apparatus and a second sample separation apparatus, wherein the first sample separation apparatus and the second sample separation apparatus comprise separate independent flow paths, the first sample separation apparatus comprises a first fluid drive unit configured for driving a first mobile phase and/or the fluidic sample and a first sample separation unit configured for separating the fluidic sample, and the second sample separation apparatus comprises a second fluid drive unit configured for driving a second mobile phase and/or the fluidic sample and a second sample separation unit configured for separating the fluidic sample, the injector comprising:
a valve arrangement fluidically connectable to the first sample separation apparatus and to the second sample separation apparatus, wherein the valve arrangement comprises a single fluid valve;
a sample accommodation volume for accommodating the fluidic sample, wherein the sample accommodation volume is provided as a single common sample accommodation volume for accommodating the fluidic sample to be injected selectively into the at least one selected one of the first sample separation apparatus and the second sample separation apparatus, wherein:
the fluid valve is switchable to at least one feed injection state at which the fluid valve establishes at least one fluidic connection point; and
the fluid valve is configured to inject the fluidic sample into the at least one selected one of the first sample separation apparatus and the second sample separation apparatus by combining, at the at least one fluidic connection point, a sample flow from a first inlet flow path supplying the fluidic sample from the sample accommodation volume with a mobile phase flow from a second inlet flow path supplying the first mobile phase or the second mobile phase, so that a combination of the fluidic sample and the first mobile phase or the second mobile phase flows from the at least one fluidic connection point into at least one outlet flow path towards at least one the first sample separation apparatus or the second sample separation apparatus; and

a control unit configured to control the valve arrangement so that the fluidic sample in the sample accommodation volume is selectively injectable into at least one of the first sample separation apparatus or the second sample separation apparatus.

2. The injector according to claim 1 , wherein the sample accommodation volume is fluidically connected with the valve arrangement or forms part of the valve arrangement.

3. The injector according to claim 1 , wherein the valve arrangement comprises a stator and a rotor being movable relative to the stator, wherein the stator comprises a plurality of ports to be connected at least to the first sample separation apparatus, the second sample separation apparatus and the sample accommodation volume, and the rotor comprises one or more conduits, wherein different fluidic coupling and/or decoupling states between the ports and the one or more conduits are establishable by switching the valve arrangement.

4. The injector according to claim 1 , comprising a metering unit configured for driving the fluidic sample to flow into the sample accommodation volume.

5. The injector according to claim 1 , comprising a needle and a seat, wherein the needle is configured to be movable out of the seat and into a sample container for transferring the fluidic sample from the sample container into the sample accommodation volume, and wherein the needle is drivable back into the seat for injecting the transferred fluidic sample from the sample accommodation volume into the at least one selected one of the first sample separation apparatus or the second sample separation apparatus.

6. The injector according to claim 5 , wherein the needle and the seat are provided as a single common needle-seat arrangement for transferring the fluidic sample.

7. The injector according to claim 1 , configured for pre-compressing the fluidic sample in the sample accommodation volume before injecting the fluidic sample into the at least one selected one of the first sample separation apparatus and the second sample separation apparatus.

8. The injector according to claim 7 , configured for pre-compressing the fluidic sample in the sample accommodation volume up to a pre-compression pressure value which is below a system pressure value of at least one of the first sample separation apparatus or the second sample separation apparatus.

9. The injector according to claim 1 , configured for decompressing the sample accommodation volume after injecting the fluidic sample into the at least one selected one of the first sample separation apparatus and the second sample separation apparatus and before accommodating further fluidic sample in the sample accommodation volume.

10. The injector according to claim 1 , comprising a flushing unit configured to flush at least one selected from the group consisting of: the sample accommodation volume; a needle; a seat; at least a part of ports of the injector; at least a part of conduits of the injector; and at least a part of conduits of at least one of the first sample separation apparatus or the second sample separation apparatus.

11. The injector according to claim 1 , wherein the control unit is configured to control the valve arrangement so that a fluidic sample separation procedure runs in one of the first sample separation apparatus or the second sample separation apparatus, while the other of the first sample separation apparatus and the second sample separation apparatus performs another task.

12. The injector according to claim 1 , wherein:
the at least one feed injection state comprises a first feed injection state and a second feed injection state;
the at least one fluidic connection point comprises a first fluidic connection point and a second fluidic connection point;
the at least one outlet flow path comprises a first outlet flow path and a second outlet flow path;
at the first feed injection state, the fluid valve is configured to inject the fluidic sample from the sample accommodation volume into the first sample separation apparatus by combining, at the first fluidic connection point, the sample flow from the first inlet flow path supplying the fluidic sample from the sample accommodation volume with the mobile phase flow from the second inlet flow path supplying the first mobile phase, so that a combination of the fluidic sample and the first mobile phase flows from the first fluidic connection point into the first outlet flow path towards the first sample separation apparatus; and
at the second feed injection state, the fluid valve is configured to inject the fluidic sample from the sample accommodation volume into the second sample separation apparatus by combining, at the second fluidic connection point, the sample flow from the first inlet flow path supplying the fluidic sample from the sample accommodation volume with a mobile phase flow from a further second inlet flow path supplying the second mobile phase, so that a combination of the fluidic sample and the second mobile phase flows from the second fluidic connection point into the second outlet flow path towards the second sample separation apparatus.

13. The injector according to claim 1 , wherein the at least one fluidic connection point is integral with the fluid valve.

14. A sample separation system for separating a fluidic sample, the sample separation system comprising:
a first sample separation apparatus for separating

Assignees

• Agilent Technologies Inc

Inventors

• Ortmann Thomas

Classifications

• G01N2030/207

  with metering cavity, e.g. sample loop · CPC title

• G01N2030/202

  rotary valves · CPC title

• G01N30/6043

  in parallel · CPC title

• G01N30/466

  with separation columns in parallel · CPC title

• G01N30/22

  in high pressure liquid systems · CPC title