Liquid pumping cassettes and associated pressure distribution manifold and related methods

Patent metadata

Field	Value
Publication number	US-12078162-B2
Application number	US-202318167736-A
Country	US
Kind code	B2
Filing date	Feb 10, 2023
Priority date	Mar 30, 2018
Publication date	Sep 3, 2024
Grant date	Sep 3, 2024

Abstract

A fluid-handling cassette comprising a plurality of diaphragm valves and pumps is configured to have its actuation ports located along a thin or narrow edge of the cassette. Actuation channel % within the cassette lead from the actuation ports to actuation chambers of the valves and pumps in a space between plates that comprise the cassette. The individual plates have a nominal thickness that is sufficient to provide a rigid ceiling for the actuation channels, but sufficiently thin to minimize the overall thickness of the cassette. The cassette can be plugged into or unplugged from an actuation receptacle or a manifold by its narrow edge. A plurality of such cassettes can be stacked together or spaced apart from each other to form a cassette assembly, providing for a convenient way to install and remove the cassette assembly from its actuation receptacle. The arrangement allows for an improved way of connecting a complex cassette assembly to its associated pressure distribution manifold without the use of a plurality of flexible connecting tubes between the two.

First claim

What is claimed is:

1. A liquid handling cassette comprising:
a midplate positioned between a first plate and a second plate, the midplate comprising a first side with a plurality of channel walls projecting from the first side, and a second side with a plurality of channel walls projecting from the second side, wherein the first plate contacts the channel walls on the first side of the midplate and the second plate contacts the channel walls on the second side of the midplate;
a plurality of edges each of which is perpendicular to the first side and coinciding with an outer edge of the midplate;
a pump station with a pump actuation chamber defined by a pump diaphragm and the first plate, said pump diaphragm seated against the first side of the midplate; and
a pump actuation channel defined by at least two channel walls of the plurality of channel walls on the first side of the midplate and fluidically connecting the pump actuation chamber with a cassette pump actuation port positioned at a first edge of the plurality of edges and located between the midplate and the first plate.

2. The liquid handling cassette of claim 1 , wherein the plurality of channel walls on the second side of the mid-plate define one or more liquid channels.

3. The liquid handling cassette of claim 2 , wherein the pump station further comprises a first and a second pump port fluidically connecting a pumping chamber to a respective first and second liquid channels, the pumping chamber defined by the pump diaphragm and the first side of the midplate.

4. The liquid handling cassette of claim 2 , comprising a pump port in the pump station fluidically connecting a liquid channel on the second side of the mid-plate, with a pumping chamber defined by the pump diaphragm and the first side of the mid-plate.

5. The liquid handling cassette of claim 4 , comprising a liquid channel on the second side of the midplate fluidically connected the pumping chamber to a cassette liquid port located at the first edge of the cassette and between the midplate and the second plate.

6. The liquid handling cassette of claim 4 , wherein the pump station is further defined by a perimeter wall with a wall port that fluidically connects the pump actuation chamber with the pump actuation channel.

7. The liquid handling cassette of claim 1 , wherein the midplate further comprises:
a perimeter wall around the pump station with a wall port in the wall, the perimeter wall projecting from a first side of the midplate; and
the pump diaphragm located on the midplate within the perimeter wall, the diaphragm including a bead on an outer edge of the pump diaphragm; and
wherein the first plate further comprises:
a retaining wall projecting from the first side to a distance sufficient to compress the bead of the pump diaphragm against the midplate, the retaining wall located and sized to fit within the perimeter wall.

8. The liquid handling cassette of claim 7 , wherein the retaining wall fits within the perimeter wall creating an annular gap, the annular gap being in fluid communication with the actuation channel, the retaining wall including one or more fenestrations to provide a fluid path between the actuation chamber and the annular gap.

9. The liquid handling cassette of claim 8 , wherein the first plate further comprises a curved surface within the retaining wall that is shaped to support the pump diaphragm.

10. The liquid handling cassette of claim 9 , wherein the curved surface within the retaining wall further comprises a groove that extends from one fenestration across the pump diaphragm to an opposite side of the retaining wall.

11. A liquid handling cassette comprising:
a midplate positioned between a first plate and a second plate, the midplate comprising a plurality of channel walls projecting from a first side and, a second side with a plurality of channel walls projecting from the second side, wherein the first plate contacts the channel walls on the first side of the midplate and the second plate contacts the channel walls on the second side of the midplate;
a plurality of edges, each of which is perpendicular to the first side and coinciding with an outer edge of the midplate;
a valve station comprising a valve actuation chamber defined by a valve diaphragm and the first plate, said valve diaphragm seated against the first side of the midplate; and
a valve actuation channel defined by at least two channel walls of the plurality of channel walls on the first side of the midplate and fluidically connecting the valve actuation chamber with a cassette valve actuation port positioned at a first edge of the plurality of edges and located between the mid-plate and the first plate.

12. The liquid handling cassette of claim 1 or claim 11 , wherein the midplate is formed of an opaque material and the first plate and second plate are transparent or translucent.

13. The liquid handling cassette of claim 12 , wherein the first plate and second plate permit transmission of laser wavelengths and the midplate is opaque.

14. The liquid handling cassette of claim 12 , wherein the first plate and second plate are laser welded to the midplate.

15. The liquid handling cassette of claim 14 , wherein the first and second plates are laser welded to the channel walls.

16. The liquid handling cassette of claim 11 , wherein the midplate further comprises:
a perimeter wall around the valve station with a wall port in the wall, the perimeter wall projecting from a first side of the midplate; and
the valve diaphragm located on the midplate within the perimeter wall, the valve diaphragm including a bead on an outer edge of the valve diaphragm; and
wherein the first plate further comprises:
a retaining wall projecting from the first side to a distance sufficient to compress the bead of the valve diaphragm against the midplate, the retaining wall located and sized to fit within the perimeter wall.

17. The liquid handling cassette of claim 16 , wherein the retaining wall fits within the perimeter wall creating an annular gap, the annular gap being in fluid communication with the actuation channel, the retaining wall including one or more fenestrations to provide a fluid path between the actuation chamber and the annular gap.

18. The liquid handling cassette of claim 11 , wherein the plurality of channel walls on the second side of the midplate define one or more liquid channels.

19. The liquid handling cassette of claim 18 , wherein the valve station further comprises a first and a second valve port fluidically connecting a valve chamber to a respective first and second liquid channels, the valve chamber defined by the valve diaphragm and the first side of the midplate.

20. The liquid handling cassette of claim 11 , comprising a valve port in the valve station fluidically connecting a liquid channel on the second side of the midplate, with a valve chamber defined by the valve diaphragm and the first side of the mid-plate.

21. The liquid handling cassette of claim 11 , comprising a liquid channel on the second side of the midplate fluidically connecting the valve chamber to a cassette liquid port located at the first edge of the cassette and between the midplate and the second plate.

22. The liquid handling cassette of claim 11 , wherein the valve station is further defined by a perimeter wall with a wall port that fluidically connects the valve actuation chamber with the valve actuation channel.

23. The liquid handling cassette of

Assignees

• Deka Products Lp

Inventors

• Grant Kevin L
• Colburn Benjamin E
• Rauseo Joseph M
• Doucette Benjamin J
• Gorayeb Marc J

Classifications

• A61M1/155

  with treatment-fluid pumping means or components thereof · CPC title

• A61M1/15625

  the reservoirs acting as balance chambers · CPC title

• A61M1/1561

  at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil · CPC title

• A61M1/1565

  Details of valves · CPC title

• A61M1/154

  with sensing means or components thereof · CPC title