Diffusing alpha-emitter radiation therapy for colon cancer
US-2022395700-A1 · Dec 15, 2022 · US
Diffusing alpha-emitter radiation therapy for colorectal cancer
US12076582B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12076582-B2 |
| Application number | US-202318094408-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 9, 2023 |
| Priority date | Jun 10, 2021 |
| Publication date | Sep 3, 2024 |
| Grant date | Sep 3, 2024 |
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Abstract
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A method for treating a tumor, comprising identifying a tumor as a colorectal cancer tumor and implanting in the tumor identified as a colorectal cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source ( 21 ) with a suitable radon release rate and for a given duration, such that the source ( 21 ) provides during the given duration a cumulated activity of released radon between 3.7 Mega becquerel (MBq) hour and 9.2 MBq hour, per centimeter length.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for treating a colorectal cancer tumor, comprising: identifying a tumor as a colorectal cancer tumor; and implanting in the tumor identified as a colorectal cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the at least one DaRT source provides during the given duration a cumulated activity of released radon between 4.9 Mega becquerel (MBq) hour and 8 MBq hour, per centimeter length. 2. The method of claim 1 , wherein implanting the at least one DaRT source comprises implanting an array of DaRT sources, each DaRT source separated from its neighboring DaRT sources in the array by not more than 4 millimeters. 3. The method of claim 2 , wherein implanting the at least one DaRT source comprises implanting an array of DaRT sources in a hexagonal arrangement, each DaRT source separated from its neighboring DaRT sources in the array by not more than 4 millimeters. 4. The method of claim 1 , wherein the at least one DaRT source has a radon release rate of between 1.2 and 1.7 microcurie per centimeter length. 5. The method of claim 4 , wherein the at least one DaRT source has a radon release rate of between 1.3 and 1.6 microcurie per centimeter length. 6. The method of claim 1 , wherein the method comprises selecting the given duration before implanting the at least one DaRT source in the tumor, and removing the at least one DaRT source from the tumor after the given duration from the implanting of the at least one DaRT source has passed. 7. The method of claim 1 , wherein the at least one DaRT source provides during the given duration a cumulated activity of released radon between 5.3 Mega becquerel (MBq) hour and 7.5 MBq hour, per centimeter length.
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using functional images, e.g. PET or MRI · CPC title
Seeds · CPC title
Ions; Protons · CPC title
using a specific method of dose optimization · CPC title
- A61N5/1027Primary
Interstitial radiation therapy · CPC title
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- What does patent US12076582B2 cover?
- A method for treating a tumor, comprising identifying a tumor as a colorectal cancer tumor and implanting in the tumor identified as a colorectal cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source ( 21 ) with a suitable radon release rate and for a given duration, such that the source ( 21 ) provides during the given duration a cumulated activity of released rado…
- Who is the assignee on this patent?
- Alpha Tau Medical Ltd
- What technology area does this patent fall under?
- Primary CPC classification A61N5/1027. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 03 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).