Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects

Patent metadata

Field	Value
Publication number	US-12076301-B2
Application number	US-202117407043-A
Country	US
Kind code	B2
Filing date	Aug 19, 2021
Priority date	Sep 27, 2013
Publication date	Sep 3, 2024
Grant date	Sep 3, 2024

Abstract

In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.

First claim

What is claimed is:

1. An electrical stimulation system, comprising:
a pulse generator configured to neuromodulate the cervical spinal cord of a patient by providing an electrical signal to at least one surface stimulation electrode attached to a dorsal aspect of the neck of the patient; and
wherein at least one of an amplitude and a frequency of the electrical signal are selected to improve, when the electrical signal is provided to the at least one surface stimulation electrode, at least one of voluntary motor control or grip strength of a hand of the patient.

2. The electrical stimulation system of claim 1 , wherein:
the at least one of the amplitude and the frequency of the electrical signal, when the electrical signal is provided to the at least one surface stimulation electrode, does not evoke a painful sensation.

3. The electrical stimulation system of claim 1 , wherein:
the pulse generator is electrically connected to:
a cathode electrode attached to the dorsal aspect of the neck, the at least one surface stimulation electrode comprising the cathode electrode; and a grounding electrode attached to the patient remote from the cathode electrode.

4. The electrical stimulation system of claim 1 , wherein:
the at least one of the amplitude and the frequency of the electrical signal are further configured to reduce a time needed to initiate a force following a patient command.

5. The electrical stimulation system of claim 1 , wherein:
the at least one of the amplitude and the frequency of the electrical signal are further configured to increase activation levels of motor pools of the hand of the patient.

6. The electrical stimulation system of claim 5 , wherein:
the increase in activation levels of motor pools of the hand of the patient comprises an increase in surface EMG amplitudes of at least one intrinsic or extrinsic muscle of the hand.

7. The electrical stimulation system of claim 5 , wherein:
the amplitude of the electrical signal is between 20 mA and 100 mA; and
the frequency of the electrical signal is between 5 Hz and 30 Hz.

8. An electrical stimulation system, comprising:
a pulse generator configured to neuromodulate the cervical spinal cord of a patient by providing an electrical signal to at least one implanted stimulation electrode positioned to provide stimulation to at least a portion of the cervical spinal cord of the patient; and
wherein at least one of an amplitude and a frequency of the electrical signal are selected to improve, when the electrical signal is provided to the at least one implanted stimulation electrode, at least one of voluntary motor control or grip strength of a hand of the patient.

9. The electrical stimulation system of claim 8 , wherein:
a implanted epidural electrode array comprises the at least one implanted stimulation electrode.

10. The electrical stimulation system of claim 8 , wherein:
the at least one implanted stimulation electrode comprises at least one cathode and at least one anode selected based on activation of hand muscles.

11. The electrical stimulation system of claim 8 , wherein:
the at least one of the amplitude and the frequency of the electrical signal are further configured to reduce response time.

12. The electrical stimulation system of claim 8 , wherein:
the at least one of the amplitude and the frequency of the electrical signal are further configured to increase activation levels of motor pools of the hand of the patient.

13. The electrical stimulation system of claim 8 , wherein:
the amplitude of the electrical signal is between 0.1 mA and 10 mA; and
the frequency of the electrical signal is between 5 Hz and 60 Hz.

14. A neuromodulation method, comprising:
providing an electrical signal to at least one electrode, the at least one electrode positioned to provide cervical stimulation to a patient;
measuring at least one of a maximum of a grip force of a hand of the patient, accuracy in controlling the grip force of the hand of the patient, or response time in changing the grip force of the hand of the patient; and
configuring a stimulator to provide an updated electrical signal to the at least one electrode, the updated electrical signal based on the measured at least one of the maximum of the grip force, the accuracy in controlling the grip force, or the response time in changing the grip force.

15. The neuromodulation method of claim 14 , wherein:
an implanted extradural array comprises the at least one electrode.

16. The neuromodulation method of claim 14 , wherein:
the at least one electrode comprises at least one cathodic electrode and at least one anodic electrode; and
the neuromodulation method further comprises selecting at the at least one cathodic electrode and the at least one anodic electrode based on spinal cord evoked potentials induced by the at least one cathodic electrode and the at least one anodic electrode.

17. The electrical stimulation system of claim 14 , wherein:
the updated electrical signal has an amplitude between 0.1 mA and 10 mA and a frequency between 5 Hz and 60 Hz.

18. The neuromodulation method of claim 14 , wherein:
the at least one electrode comprises a cathodic surface stimulation electrode.

19. The neuromodulation method of claim 14 , wherein:
the updated electrical signal has an amplitude between 20 mA and 100 mA and a frequency between 5 Hz and 30 Hz.

20. The neuromodulation method of claim 14 , wherein:
the updated electrical signal does not evoke a painful sensation.

Assignees

• Univ California

Inventors

• Lu Daniel C
• Edgerton V Reggie
• Roy Roland R
• Gerasimenko Yury P

Classifications

• A61N1/36003

  of motor muscles, e.g. for walking assistance · CPC title

• A61K31/527

  spiro-condensed · CPC title

• A61N1/36034

  specified by the stimulation parameters · CPC title

• A61K31/517

  ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine · CPC title

• A61K31/506

  not condensed and containing further heterocyclic rings · CPC title