Systems and methods to restore perfusion to a vessel

Patent metadata

Field	Value
Publication number	US-12076037-B2
Application number	US-202318232449-A
Country	US
Kind code	B2
Filing date	Aug 10, 2023
Priority date	Mar 9, 2011
Publication date	Sep 3, 2024
Grant date	Sep 3, 2024

Abstract

Methods and systems for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to achieve a clinically effective revascularization or perfusion rate for clots comprising a higher ratio of red blood cells to fibrin.

First claim

What is claimed is:

1. A method of restoring blood flow in neurovasculature by removing thrombus in human patients experiencing ischemic stroke, the method comprising:
delivering a dual-layer clot retrieval device to a blood vessel of a respective human patient of a plurality of human patients for retrieving a clot;
passing the dual layer clot retrieval device by, through, or about the clot in two passes or less; and
removing the dual layer clot retrieval device after two passes or less, to improve a final revascularization rate under a modified treatment in cerebral infarction score (mTICI) for approximately 42% of the human patients in the plurality of human patients.

2. The method of claim 1 , further comprising achieving a good clinical outcome of mRS from approximately 71.1% to approximately 81.3% under a modified Rankin Scale (mRS) score of 0-2 within a predetermined time period comprising 90-days following restoring perfusion to the blood vessel.

3. The method of claim 1 , further comprising achieving a reduced clot fracturing after two passes of the dual layer clot retrieval device by, through, or about the clot.

4. The method of claim 1 , further comprising achieving approximately an 80% final revascularization rate mTICI greater than 2b after two passes of the dual layer clot retrieval device by, through, or about the clot.

5. The method of claim 4 , wherein further comprising restoring perfusion to the blood vessel after a single pass of the dual layer clot retrieval device by, through, or about the clot and removing the dual layer clot retrieval device to achieve a final revascularization rate mTICI≥2c-3 in approximately 80% of human patients in the plurality of human patients.

6. The method of claim 1 , wherein the clot is located in one of the following locations: a carotid artery, a MI middle cerebral artery, a M2 middle cerebral artery, a basilar artery, and a vertebral artery.

7. The method of claim 1 , wherein the dual-layer clot retrieval device comprises:
a first framework of struts forming a tubular main body portion; and
a second framework of struts forming an outer tubular body at least partially surrounding the tubular main body portion, wherein the outer tubular body is expandable to a radial extent to define a clot reception space.

8. The method of claim 7 , wherein
the tubular main body portion further comprises a porous inner body, and
the outer tubular body comprises a plurality of longitudinally spaced clot scaffolding segments comprising closed cells whereby each of the plurality of longitudinally spaced clot scaffolding segment is separated by a clot inlet mouth and at least one closed cell of each of the plurality of longitudinally spaced clot scaffolding segment terminates in a distal apex free from connection to an adjacent closed cell.

Assignees

• Neuravi Ltd

Inventors

• Brady Eamon
• Casey Brendan
• Gilvarry Michael
• Hardiman David
• Mcardle Kevin
• Razavi Mahmood K
• Vale David
• Griffin Patrick
• Mcnamara Jason
• Claffey Mairsil

Classifications

• A61M29/02

  Dilators made of swellable material {(balloon catheters for angioplasty A61M25/104)} · CPC title

• A61F2/013

  Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting · CPC title

• A61B2017/2215

  having an open distal end · CPC title

• A61M29/00

  Dilators with or without means for introducing media, e.g. remedies · CPC title

• A61B2017/2212

  having a closed distal end, e.g. a loop · CPC title