Flexible tube for endoscope, endoscopic medical device, and methods for producing the same

Patent metadata

Field	Value
Publication number	US-12075976-B2
Application number	US-202117343899-A
Country	US
Kind code	B2
Filing date	Jun 10, 2021
Priority date	Jan 16, 2019
Publication date	Sep 3, 2024
Grant date	Sep 3, 2024

Abstract

Provided are a flexible tube for an endoscope, the flexible tube having a flexible tube base containing metal as a constituent material, a resin cover layer that covers an outer periphery of the flexible tube base, and a primer layer that includes a specific silane coupling agent and that is disposed between the flexible tube base and the resin cover layer, in which the resin cover layer includes at least one compound selected from the group consisting of polyamides, polyesters, polyurethanes, and polyolefins at least on a side of the resin cover layer in contact with the primer layer, an endoscopic medical device including the flexible tube for an endoscope, a method for producing the flexible tube for an endoscope, and a method for producing the endoscopic medical device.

First claim

What is claimed is:

1. A flexible tube for an endoscope, the flexible tube comprising:
a flexible tube base containing metal as a constituent material;
a resin cover layer that covers an outer periphery of the flexible tube base; and
a primer layer that includes a compound represented by general formula (1) and that is disposed between the flexible tube base and the resin cover layer,
wherein the resin cover layer includes at least one compound selected from the group consisting of polyamides, polyesters, polyurethanes, and polyolefins at least on a side of the resin cover layer in contact with the primer layer:

where LL 1 represents a monovalent substituent or an n1-valent linking group, L 1 represents a single bond or a divalent linking group, Y 1 to Y 3 each represent a substituent, and n1 is an integer of 1 to 4,
at least one of Y 1 , Y 2 , or Y 3 is a group selected from the group consisting of alkoxy groups and a hydroxy group, and when n1 is 1, none of LL 1 -L 1 and Y 1 to Y 3 is a group selected from the group consisting of alkoxy groups and a hydroxy group.

2. The flexible tube for an endoscope according to claim 1 , wherein the compound represented by general formula (1) is a compound represented by any one of general formulae (2) to (4):

where LL 1a represents a hydrogen atom, an alicyclic group, a heterocyclic group, a hydroxy group, a sulfanyl group, an isocyanato group, a thiocyanato group, an ureido group, a cyano group, an acid anhydride group, an azide group, a carboxy group, an acyl group, a thiocarbamoyl group, a phosphate group, a phosphanyl group, a sulfonic group, or a sulfamoyl group;
L 2 represents a single bond, an alkylene group, an alkenylene group, an alkynylene group, an arylene group, —O—, —S—, —NR a —, an ester bond, a thioester bond, an amide bond, a thioamide bond, a sulfonyl group, or a divalent group which is a combination of two or more selected from the group consisting of the aforementioned groups and bonds;
L 3 to L 5 each represent a single bond, an alkylene group, an alkenylene group, an alkynylene group, an arylene group, —O—, —S—, —NR a —, an ester bond, a thioester bond, an amide bond, a thioamide bond, a urea bond, a thiourea bond, a sulfonyl group, a sulfonamide bond, or a divalent group which is a combination of two or more selected from the group consisting of the aforementioned groups and bonds;
LL 1b represents a single bond, an alkylene group, an alkenylene group, an alkynylene group, an arylene group, —O—, —S—, —NR a —, a divalent heterocyclic group, an amide bond, an ester bond, a thioester bond, a divalent phosphate group, a phosphanediyl group, a sulfonyl group, or a divalent group which is a combination of two or more selected from the group consisting of the aforementioned groups and bonds;
LL 1c represents an n2-valent alkane, an n2-valent alkene, an n2-valent alkyne, an n2-valent arene, an n2-valent heterocyclic group, a trivalent phosphate group, a phosphanetriyl group, an isocyanurate group, or an n2-valent group which is a combination of two or more groups and bonds selected from the group consisting of the aforementioned groups, alkylene a thioester bond, an amide bond, a thioamide bond, and a sulfonyl group;
R a represents a hydrogen atom or a substituent;
Y 4 , Y 7 , Y 10 , and Y 13 each represent a hydroxy group or an alkoxy group;
Y 5 , Y 6 , Y 8 , Y 9 , Y 11 , Y 12 , Y 14 , and Y 15 each represent a hydroxy group, an alkoxy group, an alkyl group, or a ketoxime group; and
n2 is 3 or 4.

3. The flexible tube for an endoscope according to claim 2 ,
wherein, in general formula (2),
LL 1a represents a hydrogen atom, an alicyclic group, a heterocyclic group, a hydroxy group, a sulfanyl group, a thiocyanato group, an acid anhydride group, a carboxy group, an acyl group, or a sulfonic group, and
L 2 represents an alkylene group, an alkenylene group, an alkynylene group, an arylene group, —O—, —S—, —NR a —, an ester bond, a thioester bond, an amide bond, a sulfonyl group, or a divalent group which is a combination of two or more selected from the group consisting of the aforementioned groups and bonds.

4. The flexible tube for an endoscope according to claim 2 ,
wherein, in general formula (2),
LL 1a represents a hydrogen atom, a hydroxy group, a carboxylic acid anhydride group, a carboxy group, an acyl group, or a sulfonic group, and
L 2 represents an alkylene group, an alkenylene group, —O—, —NR a —, an ester bond, an amide bond, or a divalent group which is a combination of two or more selected from the group consisting of the aforementioned groups and bonds.

5. The flexible tube for an endoscope according to claim 2 ,
wherein, in general formula (3),
LL 1b represents an alkylene group, an alkenylene group, an arylene group, —O—, —S—, an ester bond, a thioester bond, an amide bond, a sulfonyl bond, or a divalent group which is a combination of two or more selected from the group consisting of the aforementioned groups and bonds, and
L 3 and L 4 each represent a single bond, an alkylene group, an alkenylene group, an alkynylene group, an arylene group, —O—, —S—, an ester bond, a thioester bond, an amide bond, a sulfonyl group, or a divalent group which is a combination of two or more selected from the group consisting of the aforementioned groups and bonds.

6. The flexible tube for an endoscope according to claim 2 ,
wherein, in general formula (3),
LL 1b represents an alkylene group, an alkenylene group, an arylene group, —O—, —S—, an ester bond, a thioester bond, an amide bond, a sulfonyl bond, or a divalent group which is a combination of two or more selected from the group consisting of the aforementioned groups and bonds, and
L 3 and L 4 each represent a single bond, an alkylene group, an alkenylene group, —O—, an ester bond, or an amide bond.

7. The flexible tube for an endoscope according to claim 2 ,
wherein, in general formula (4), n2 is 3, LL 1c represents an isocyanurate group, and L 5 represents an alkylene group.

8. The flexible tube for an endoscope according to claim 1 , wherein the metal that constitutes the flexible tube base is stainless steel.

9. The flexible tube for an endoscope according to claim 1 , wherein the metal that constitutes the flexible tube base has a passivation film on a surface thereof.

10. The flexible tube for an endoscope according to claim 1 , wherein the resin cover layer has a single-layer structure or a multilayer structure and includes at least one compound selected from the group consisting of polyamides, polyesters, polyurethanes, and polyolefins in a layer in contact with the primer layer.

11. The flexible tube for an endoscope according to claim 1 , wherein the resin cover layer includes at least one compound selected from the group consisting of polyamides, polyesters, and polyurethanes at least on the side of the resin cover layer in contact with the primer layer.

12. The flexible tube for an endoscope according to claim 1 ,
wherein the resin cover layer has a two-layer structure, and
a ratio of a thickness of an inner layer to a thickness of an outer layer of the two-layer structure changes in a gradient manner in an axial direction of the flexible tube base.

13. The flexible tube for an endoscope according to claim 12 , wherein the ratio of the thickness of the inner layer to the thickness of

Assignees

• Fujifilm Corp

Inventors

• Nakai Yoshihiro
• Yoshitani Toshihide
• Abe Shinya
• Horita Kazuma
• Senga Takeshi

Classifications

• B32B2535/00

  Medical equipment, e.g. bandage, prostheses or catheter · CPC title

• A61L2420/08

  Coatings comprising two or more layers · CPC title

• B32B15/08

  of synthetic resin · CPC title

• B32B27/08

  of synthetic resin · CPC title

• B32B15/18

  comprising iron or steel {(B32B15/011, B32B15/012 and B32B15/013 take precedence)} · CPC title