Core stabilized microcapsules, method of their preparation and uses thereof

Patent metadata

Field	Value
Publication number	US-12070629-B2
Application number	US-202117340334-A
Country	US
Kind code	B2
Filing date	Jun 7, 2021
Priority date	Dec 31, 2009
Publication date	Aug 27, 2024
Grant date	Aug 27, 2024

Abstract

The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

First claim

What is claimed is:

1. A microcapsule comprising a core encapsulated by a metal oxide shell, wherein said core comprises at least one active agent, and at least one phase changing material; wherein the thickness of said metal oxide shell is in the range of 0.05-1 micron;
wherein said metal oxide shell is made from (a) metal oxide nanoparticles, and (b) a hydrolyzed and polymerized sol gel precursor; wherein said at least one active agent is in a solid form, and is a dermatological agent; wherein said at least one phase changing material is not liquid at room temperature; wherein said core has a viscosity of from about 300 cP to about 1,000,000 cP.

2. The microcapsule according to claim 1 , wherein said at least one phase changing material is selected from the group consisting of natural or synthetic paraffin, waxes, aliphatic alcohols, fatty acids, and any combination thereof, wherein said fatty acids have a formula of CH3(CH2)nCOOH, and wherein n=10-100.

3. The microcapsule of claim 1 , wherein said dermatological agent is selected from the group consisting of anti-fungal agents, anti-bacterial agents, anti-inflammatory agents, anti-pruritic agents, anti-psoriatic agents, anti-acne agents, anti-rosacea agents, and any combinations thereof.

4. The microcapsule of claim 3 , wherein said anti-acne agent is selected from the group consisting of benzoyl peroxide or a retinoid.

5. The microcapsule according to claim 1 , wherein said microcapsule is stable for a period of between about 2 weeks to about 2 years at room temperature.

6. A composition comprising the microcapsule of claim 1 .

7. The composition of claim 6 , wherein said composition is a pharmaceutical composition and further comprises at least one pharmaceutical acceptable carrier or excipient.

8. A method for treating a skin disease, disorder or condition in a subject in need thereof, said method comprising topically administering to said subject a composition according to claim 7 , wherein said at least one active agent is benzoyl peroxide or a retinoid, wherein said benzoyl peroxide or retinoid is in a solid form; and wherein said skin disease, disorder or condition is selected from the group consisting of acne, psoriasis, seborrhea, contact dermatitis, rosacea, and a combination thereof.

Assignees

• Sol Gel Tech Ltd

Inventors

• Toledano Ofer
• Bar-Simantov Haim
• Sertchook Hanan
• Fireman-Shoresh Sharon
• Marco Dorit

Classifications

• A61K9/10

  Dispersions; Emulsions · CPC title

• F28D20/023

  the latent heat storage material being enclosed in granular particles or dispersed in a porous, fibrous or cellular structure · CPC title

• B01J13/18

  In situ polymerisation with all reactants being present in the same phase · CPC title

• A61K9/5026

  obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title