Apparatus and method for magnetic particle imaging and thermotherapy fusion based on field-free line inertial scanning

Patent metadata

Field	Value
Publication number	US-12070614-B2
Application number	US-202318115888-A
Country	US
Kind code	B2
Filing date	Mar 1, 2023
Priority date	Apr 22, 2022
Publication date	Aug 27, 2024
Grant date	Aug 27, 2024

Abstract

An apparatus and a method for magnetic particle imaging and thermotherapy fusion based on field-free line inertial scanning comprises a magnetic body group, an induction coil, a living body bed, a control device, a display device, an image processing device and a cooling system. The magnetic body group comprises a long curved magnetic body pair and a cylindrical magnetic body. The control device is used to scan and image the target living body and perform thermotherapy on a preset area.

First claim

The invention claimed is:

1. An apparatus for magnetic particle imaging and thermotherapy fusion based on field-free line inertial scanning, comprising:
a magnetic body group;
an induction coil;
a living body bed;
a control device;
a display device; and
an image processing device,
wherein the magnetic body group further comprises a long curved magnetic body pair and a cylindrical magnetic body,
wherein the long curved magnetic body pair comprises two long curved magnetic bodies, each of the two long curved magnetic bodies comprises a first structural member, a second structural member and a third structural member,
wherein the first structural member and the third structural member are U-shaped magnetic bodies,
wherein the second structural member further comprises two symmetrical arc-shaped magnetic bodies prepared using a preset curvature,
wherein the first structural member is parallel to the third structural member,
wherein a plane where the second structural member is located is perpendicular to a plane where the first structural member is located,
wherein two ends of the second structural member are respectively connected to open ends of the U-shaped magnetic bodies of the first structural member and the third structural member,
wherein shapes of the long curved magnetic bodies are the same,
wherein the long curved magnetic bodies are parallel to each other,
wherein central axes of the long curved magnetic bodies are collinear,
wherein closed ends of the first structural member or the third structural member of the long curved magnetic bodies of the long curved magnetic body pair are opposite of each other,
wherein the cylindrical magnetic body is arranged in a space surrounded by the long curved magnetic body pair,
wherein an axis of the cylindrical magnetic body is perpendicular to a central axis of the long curved magnetic body pair,
wherein the long curved magnetic body pair is configured to simultaneously receive a current component in a same direction and a current component in a reverse direction for generating and translating a field-free line,
wherein through changing the current component in the same direction, a biasing position of the field-free line is adjusted,
wherein through changing the current component in the reverse direction, a gradient of a gradient magnetic field is adjusted,
wherein the cylindrical magnetic body is configured to receive a direct current component and a radiofrequency current component,
wherein the cylindrical magnetic body is configured to receive the direct current component for adjusting a depth of the field-free line in an axial direction of the cylindrical magnetic body,
wherein the cylindrical magnetic body is configured to receive the radio frequency current component for induction heating of magnetic nanoparticles in a field-free region,
wherein the control device is used to control current variation and mechanical rotation of the long curved magnetic body pair, current variation of the cylindrical magnetic body, and moving depth of the living body bed, according to a preset control command, thereby realizing translation, rotation and serial-layer scanning of the field-free line, realizing a scanning and imaging of a target living body and a positioning of the field-free line, and allowing thermotherapy to be performed on a preset area of the target living body.

2. The apparatus for magnetic particle imaging and thermotherapy fusion based on field-free line inertial scanning of claim 1 , wherein when conducting positioning of the field-free line and performing thermotherapy on the preset area of the target living body by the control device, the induction coil is in an off state.

3. A method for magnetic particle imaging and thermotherapy fusion based on field-free line inertial scanning, using the apparatus for magnetic particle imaging and thermotherapy fusion based on field-free line inertial scanning of claim 2 , comprising the steps of:
step 100 : constructing the gradient magnetic field based on the long curved magnetic body pair and forming the field-free line;
step 200 : controlling the field-free line to translationally rotate in a plane perpendicular to the axis of the cylindrical magnetic body, and performing tomographic scanning on a target living body on the living body bed to obtain electromagnetic induction signals; subsequently, preprocessing the electromagnetic induction signals to obtain a tomographic image group;
step 300 : controlling the living body bed or the field-free line to move along the axial direction of the cylindrical magnetic body to a preset depth, and serial-layer-scanning the target living body on the living body bed to obtain a complete tomographic image group;
step 400 : classifying and fusing the complete tomographic image group to obtain a three-dimensional image group;
step 500 : determining a thermotherapeutic program according to the three-dimensional image group, wherein the thermotherapeutic program includes areas to be treated, a sequence of areas to be treated, a duration of thermotherapy and a size of areas to be treated;
step 600 : constructing the gradient magnetic field based on the long curved magnetic body pair and forming the field-free line;
step 700 : controlling the field-free line to rotate around the areas to be treated and controlling the cylindrical magnetic body to generate a radio frequency magnetic field according to the thermotherapeutic program, thereby performing thermotherapy on the areas to be treated;
step 800 : repeatedly switching between an imaging mode and a thermotherapy mode until the thermotherapeutic program is completed, wherein the imaging mode dues includes steps 100 , 200 and 300 , and the thermotherapy mode includes steps 600 and 700 .

4. The method for magnetic particle imaging and thermotherapy fusion based on field-free line inertial scanning of claim 3 , wherein the tomographic image group further comprises a concentration distribution tomographic image of the magnetic nanoparticles, a temperature tomographic image of a distribution area, and a specific absorption rate tomographic image of the distribution area, wherein the three-dimensional image group further comprises a three-dimensional image of the concentration of magnetic nanoparticles, a three-dimensional image of the temperature of the distribution area, and a three-dimensional image of the specific absorption rate of the distribution area.

5. The method for magnetic particle imaging and thermotherapy fusion based on field-free line inertial scanning of claim 3 , wherein controlling the field-free line to translate and rotate in a plane perpendicular to the axis of the cylindrical magnetic body, further comprises controlling the current component in the same direction of the long curved magnetic body pair, thereby enabling the field-free line to perform reciprocating translation along a central axis direction of the long curved magnetic body pair while controlling the long curved magnetic body pair to mechanically rotate in a reciprocating manner around the axis of the cylindrical magnetic body.

6. The method for magnetic particle imaging and thermotherapy fusion based on field-free line inertial scanning of claim 3 , wherein controlling the living body bed or field-free line to move along the axis direction of the cylindrical magnetic body to a preset depth, and serial-layer-scanning the target living body on the living body bed, further comprises controlling the living body bed to deliver the target living body to a preset position in the cylindrical magnetic body, or controlling the current variation of the cylindrical magnetic body to make the field-free line to move along the axis direction of the cylindrical magnetic body to the preset depth; and

Assignees

• Univ Beihang

Inventors

• Tian Jie
• He Jie
• Hui Hui
• Zhong Jing
• An Yu
• Tang Zhenchao

Classifications

• A61N2/02

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title

• A61B5/0515 Primary

  Magnetic particle imaging · CPC title

• G01R33/0206

  Three-component magnetometers · CPC title

• G01R33/10

  Plotting field distribution {; Measuring field distribution} · CPC title

• G01R33/022

  Measuring gradient · CPC title