Method for preparing an anti-adhesion barrier film

Patent metadata

Field	Value
Publication number	US-12070534-B2
Application number	US-201916717112-A
Country	US
Kind code	B2
Filing date	Dec 17, 2019
Priority date	Sep 24, 2014
Publication date	Aug 27, 2024
Grant date	Aug 27, 2024

Abstract

The present invention relates to a surgical anti-adhesion barrier film comprising an oxidized collagen and a polyphosphate compound and to a surgical implant comprising a prosthetic fabric and such a film.

First claim

The invention claimed is:

1. A surgical implant for hernia repair comprising:
an anti-adhesion barrier film including an anti-adhesive compound including both oxidized collagen and a polyphosphate compound.

2. The surgical implant of claim 1 , wherein the polyphosphate compound is represented by a general formula, (P n O 3n+1 ) (n+2) — associated with a metal selected from the group consisting of sodium, potassium, calcium or magnesium, wherein “n” indicates an integer between 2 and 5000.

3. The surgical implant of claim 2 , wherein the metal is sodium.

4. The surgical implant of claim 1 , wherein the polyphosphate compound is a sodium polyphosphate having a degree of polymerization ranging from 2 to 100.

5. The surgical implant of claim 1 , wherein the polyphosphate compound is a sodium polyphosphate having a degree of polymerization ranging from 2 to 25.

6. The surgical implant of claim 1 , wherein the polyphosphate compound is a sodium polyphosphate having a degree of polymerization ranging from 5 to 25.

7. The surgical implant of claim 1 , wherein the polyphosphate compound includes at least one of pentasodium tripolyphosphate (Na 5 P 3 O 10 ), sodium hexametaphosphate having a degree of polymerization of 13 (NaPO 3 ) 13 , or sodium hexametaphosphate having a degree of polymerization of 25 (NaPO 3 ) 25 .

8. The surgical implant of claim 1 , wherein the anti-adhesion barrier film further includes at least one of glycerol or polyethylene glycol.

9. The surgical implant of claim 1 , wherein the anti-adhesion barrier film is sterilized via ethylene oxide.

10. The surgical implant of claim 1 , wherein the anti-adhesion barrier film is non-porous.

11. The surgical implant of claim 1 , wherein the anti-adhesion barrier film is homogenous.

12. The surgical implant of claim 1 , further comprising a prosthetic fabric in combination with the anti-adhesion barrier film to form a composite surgical implant.

13. The surgical implant of claim 12 , wherein the anti-adhesion barrier film covers an entire face of the prosthetic fabric.

14. The surgical implant of claim 12 , wherein the anti-adhesion barrier film extends beyond an outer edge of the prosthetic fabric.

15. The surgical implant of claim 14 , wherein the anti-adhesion barrier film extends beyond the outer edge of the prosthetic fabric from 5 to 10 millimeters.

16. The surgical implant of claim 12 , wherein a thickness of the anti-adhesion barrier film is between 2% and 20% of a total thickness of the composite implant.

17. The surgical implant of claim 12 , wherein the composite implant includes a first and second opposite face, wherein the first face is porous to accommodate postsurgical cell colonization therein and the second opposite face is closed by the anti-adhesion barrier film for tissue separation without adhesion.

Assignees

• Sofradim Production

Inventors

• Prost Nicolas
• Petit Delphine
• Bourges Xavier

Classifications

• C08J2489/06

  derived from leather or skin · CPC title

• C08J2389/06

  derived from leather or skin · CPC title

• C08J5/18

  Manufacture of films or sheets · CPC title

• A61L2420/08

  Coatings comprising two or more layers · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title