Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same
US-9630986-B2 · Apr 25, 2017 · US
Compositions and methods for treating CNS disorders
US12065463B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12065463-B2 |
| Application number | US-202217971865-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 24, 2022 |
| Priority date | Oct 16, 2014 |
| Publication date | Aug 20, 2024 |
| Grant date | Aug 20, 2024 |
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Abstract
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Described herein are neuroactive steroids of the Formula (I):or a pharmaceutically acceptable salt thereof, wherein , A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
First claim
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What is claimed is: 1. A compound of the formula 2. A pharmaceutical composition comprising a compound of the formula and a pharmaceutically acceptable excipient.
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Classifications
- A61K31/58Primary
containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin (digitoxin {A61K31/7048}) · CPC title
substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol · CPC title
Oxiranes · CPC title
Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00 · CPC title
the 17-beta position being substituted by a carbon atom forming part of an amide group · CPC title
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- What does patent US12065463B2 cover?
- Described herein are neuroactive steroids of the Formula (I):or a pharmaceutically acceptable salt thereof, wherein , A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of us…
- Who is the assignee on this patent?
- Sage Therapeutics Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/58. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 20 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).