Diffusing alpha-emitter radiation therapy for breast cancer

Patent metadata

Field	Value
Publication number	US-12064643-B2
Application number	US-202318094421-A
Country	US
Kind code	B2
Filing date	Jan 9, 2023
Priority date	Jun 10, 2021
Publication date	Aug 20, 2024
Grant date	Aug 20, 2024

Abstract

A method for treating a tumor, comprising identifying a tumor as a breast cancer tumor and implanting in the tumor identified as a breast cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source ( 21 ) with a suitable radon release rate and for a given duration, such that the source ( 21 ) provides during the given duration a cumulated activity of released radon between 3.5 Mega becquerel (MBq) hour and 9 MBq hour, per centimeter length.

First claim

The invention claimed is:

1. A method for treating a breast cancer tumor, comprising:
identifying a tumor as a breast cancer tumor; and
implanting in the tumor identified as a breast cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the at least one DaRT source provides during the given duration a cumulated activity of released radon between 4.5 Mega becquerel (MBq) hour and 7.5 MBq hour, per centimeter length.

2. The method of claim 1 , wherein implanting the at least one DaRT source comprises implanting an array of DaRT sources, each source separated from its neighboring DaRT sources in the array by not more than 4 millimeters.

3. The method of claim 2 , wherein implanting the at least one DaRT source comprises implanting an array of DaRT sources in a hexagonal arrangement, each DaRT source separated from its neighboring DaRT sources in the array by not more than 4 millimeters.

4. The method of claim 1 , wherein the at least one DaRT source has a radon release rate of between 1 and 1.8 microcurie per centimeter length.

5. The method of claim 4 , wherein the at least one DaRT source has a radon release rate of between 1 and 1.65 microcurie per centimeter length.

6. The method of claim 1 , wherein the method comprises selecting the given duration before implanting the at least one DaRT source in the tumor, and removing the at least one DaRT source from the tumor after the given duration from the implanting of the at least one DaRT source passed.

7. A method for treating a tumor, comprising:
identifying a tumor as a breast cancer tumor; and
implanting in the tumor identified as a breast cancer tumor, an array of diffusing alpha-emitter radiation therapy (DaRT) sources, in a regular arrangement having a spacing between each two adjacent sources of between 3.6 and 4.4 millimeters.

8. The method of claim 7 , wherein implanting the array of sources comprises implanting in a hexagonal arrangement, each source separated from its neighboring sources in the array by between 3.6 and 4 millimeters.

9. The method of claim 1 , wherein the at least one DaRT source provides during the given duration a cumulated activity of released radon between 5.5 Mega becquerel (MBq) hour and 7.5 MBq hour, per centimeter length.

10. The method of claim 1 , wherein the at least one DaRT source provides during the given duration a cumulated activity of released radon between 5.5 Mega becquerel (MBq) hour and 7 MBq hour, per centimeter length.

Assignees

• Alpha Tau Medical Ltd

Inventors

• Kelson Itzhak
• Keisari Yona
• Gat Amnon
• Den Robert
• Magen Ofer
• Domankevich Vered
• Arazi Lior
• Cooks Tomer
• Heger Guy
• Duman{Hacek Over (C)}Ić Mirta
• Luz Ishai
• Vatarescu Maayan Hedva

Classifications

• A61N5/1027 Primary

  Interstitial radiation therapy · CPC title

• A61N2005/1085

  characterised by the type of particles applied to the patient · CPC title

• A61N2005/1024

  Seeds · CPC title

• A61N2005/1019

  Sources therefor · CPC title

• A61N5/1028

  using radiation sources applied onto the body · CPC title