System and method for extracorporeal carbon monoxide removal with phototherapy

Patent metadata

Field	Value
Publication number	US-12064543-B2
Application number	US-201917257217-A
Country	US
Kind code	B2
Filing date	Jul 3, 2019
Priority date	Jul 3, 2018
Publication date	Aug 20, 2024
Grant date	Aug 20, 2024

Abstract

Systems and methods for removing carbon monoxide from whole blood are provided. In one configuration, an extracorporeal phototherapy system includes an oxygenator and a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator. The oxygenator includes a plurality of membrane layers each having a plurality of microporous hollow fiber membranes. The plurality of microporous hollow fiber membranes each include an external surface and an internal channel. Each of the plurality of membrane layers may be rotationally offset with respect to an adjacent layer. The oxygenator further includes a gas inlet port in fluid communication with a first end of the internal channels, a gas outlet port in fluid communication a second end of the internal channels, a blood inlet port, and a blood outlet port.

First claim

We claim:

1. An extracorporeal phototherapy system for removing carbon monoxide from whole blood, the extracorporeal phototherapy system comprising:
an oxygenator including:
a plurality of membrane layers each including a plurality of microporous hollow fiber membranes each having an external surface and an internal channel, wherein each of the plurality of membrane layers is rotationally offset with respect to an adjacent layer;
a gas inlet port in fluid communication with a first end of the internal channels;
a gas outlet port in fluid communication a second end of the internal channels;
a blood inlet port in fluid communication with the external surfaces; and
a blood outlet port in fluid communication with the external surfaces; and

a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator, wherein the light source is configured to emit light with a wavelength greater than 600 nanometers.

2. The extracorporeal phototherapy system of claim 1 , wherein the adjacent layers of the plurality of microporous membrane layers are offset ninety degrees from one another.

3. The extracorporeal phototherapy system of claim 1 , wherein the oxygenator includes a housing enclosing the plurality of membrane layers, and wherein the housing is fabricated from a material configured to transmit light emitted from the light source therethrough.

4. The extracorporeal phototherapy system of claim 3 , wherein the housing and the plurality of membrane layers define a planar shape or a cylindrical shape.

5. The extracorporeal phototherapy system of claim 3 , wherein the gas inlet port, the gas outlet port, the blood inlet port, and the blood outlet port are formed in the housing.

6. The extracorporeal phototherapy system of claim 1 , wherein the gas inlet port is configured to receive a flow of oxygen and the blood inlet port is configured to receive a flow of whole blood, and wherein the flow of oxygen and the flow of whole blood are in a common direction.

7. The extracorporeal phototherapy system of claim 6 , wherein a ratio of a gas flow rate of the gas flow to a blood flow rate of the flow of blood is greater than or equal to 5:1.

8. The extracorporeal phototherapy system of claim 1 , further comprising a cooling device in fluid communication with the blood outlet port.

9. The extracorporeal phototherapy system of claim 1 , wherein the plurality of membrane layers define a thickness less than 10 millimeters.

10. An extracorporeal phototherapy system for removing carbon monoxide from whole blood, the extracorporeal phototherapy system comprising:
an oxygenator including:
a plurality of membrane layers;
a gas inlet port configured to provide fluid communication through internal channels formed in each of the plurality of membrane layers and to a gas outlet port; and
a blood inlet port configured to provide fluid communication around external surfaces defined by each of the plurality of membrane layers and to a blood outlet port;

a first light source configured to output light and arranged to emit the light output by the first light source onto a first side of the oxygenator; and
a second light source configured to output light and arranged to emit the light output by the second light source onto a second side of the oxygenator opposite to the first side,
wherein the first light source and the second light source are configured to emit light with a wavelength greater than 600 nanometers.

11. The extracorporeal phototherapy system of claim 10 , wherein adjacent layers of the plurality of microporous membrane layers are offset ninety degrees from one another.

12. The extracorporeal phototherapy system of claim 10 , wherein the plurality of membrane layers each include a plurality of microporous hollow fiber membranes.

13. The extracorporeal phototherapy system of claim 10 , wherein the oxygenator includes a housing enclosing the plurality of membrane layers, and wherein the housing is fabricated from a material configured to transmit light emitted from the light source therethrough.

14. The extracorporeal phototherapy system of claim 13 , wherein the housing and the plurality of membrane layers define a planar shape or a cylindrical shape.

15. The extracorporeal phototherapy system of claim 13 , wherein the gas inlet port, the gas outlet port, the blood inlet port, and the blood outlet port are formed in the housing.

16. The extracorporeal phototherapy system of claim 10 , wherein the gas inlet port is configured to receive a flow of oxygen and the blood inlet port is configured to receive a flow of whole blood, and wherein the flow of oxygen and the flow of whole blood are in a common direction.

17. The extracorporeal phototherapy system of claim 16 , wherein a ratio of a gas flow rate of the gas flow to a blood flow rate of the flow of blood is greater than or equal to 5:1.

18. The extracorporeal phototherapy system of claim 10 , further comprising a cooling device in fluid communication with the blood outlet port.

19. The extracorporeal phototherapy system of claim 10 , wherein the plurality of membrane layers define a thickness less than 10 millimeters.

Assignees

• Massachusetts Gen Hospital

Inventors

• Zapol Warren M
• Anderson Richard Rox
• Zazzeron Luca
• Franco Walfre
• Farinelli William A
• Fischbach Anna

Classifications

• B01D2313/20

  Specific housing · CPC title

• B01D2313/903

  Integrated control or detection device · CPC title

• A61M1/3623

  Means for actively controlling temperature of blood · CPC title

• A61M2205/3606

  cooled · CPC title

• A61M2202/0233

  Carbon monoxide · CPC title