Porous medical device and methods of use

Patent metadata

Field	Value
Publication number	US-12064535-B2
Application number	US-202117184713-A
Country	US
Kind code	B2
Filing date	Feb 25, 2021
Priority date	Feb 28, 2020
Publication date	Aug 20, 2024
Grant date	Aug 20, 2024

Abstract

A medical system including a tube defining a lumen, a porous body connected to a distal end of the tube to be advanced to a target site within a subject. The porous body defines a plurality of openings, the plurality of openings are in fluid connection with the lumen, the porous body includes a first material and a second material, and the second material elutes from the porous body in the subject.

First claim

What is claimed is:

1. A medical system comprising:
a single tube defining a lumen, wherein the single tube includes a plurality of branches at a distal end of the tube; and
a porous body fixed to the distal end of the single tube and configured to be advanced to a target site within a subject, wherein the porous body defines a plurality of openings, wherein the plurality of openings are in fluid connection with the lumen, wherein the porous body includes a first material and a second material, wherein the second material is configured to elute from the porous body in the subject, wherein the porous body is fixed to the distal end of the single tube via sutures or an adhesive, wherein the porous body is at a distalmost end of the medical system, and wherein each branch of the plurality of branches rests in a corresponding channel of a plurality of channels of the porous body.

2. The medical system of claim 1 , wherein the first material includes a polymer, and wherein the second material includes one or more of a growth factor or an antibiotic.

3. The medical system of claim 1 , wherein the first material includes a hygroscopic material, and wherein the porous body is configured to be in a compressed state during insertion to the target site.

4. The medical system of claim 3 , wherein the porous body is configured to expand from the compressed state to an expanded state when the porous body contacts fluid.

5. The medical system of claim 3 , wherein the plurality of openings are fluidly disconnected from each other when the porous body is in the compressed state, and the plurality of openings are in fluid connection as the porous body expands from the compressed state to an expanded state.

6. The medical system of claim 1 , wherein the first material includes a thermoresponsive material, and wherein the porous body is configured to be in a compressed state during insertion to the target site.

7. The medical system of claim 6 , wherein the porous body is configured to expand from the compressed state to an expanded state when the porous body is heated to a temperature above a temperature threshold by body heat.

8. The medical system of claim 1 , wherein the porous body includes nanoparticles having antimicrobial properties.

9. The medical system of claim 1 , wherein the plurality of openings are formed using a crystalline material, and wherein a size and a shape of the openings is approximately equal to a size and a shape of a crystal of the crystalline material.

10. The medical system of claim 1 , further comprising a vacuum source, wherein the vacuum source is connected to the single tube and is configured to supply a negative pressure to the lumen of the single tube and the porous body.

11. The medical system of claim 3 , wherein the porous body is configured to compress from an expanded state to the compressed state when the porous body is dehydrated before insertion to the body.

12. A medical system comprising:
a single tube defining a lumen, wherein the single tube includes a plurality of branches at a distal end of the single tube; and
a porous body connected to the distal end of the single tube and configured to be advanced to a target site within a subject, wherein the porous body defines a plurality of openings, wherein the plurality of openings are in fluid connection with the lumen, wherein the porous body includes a first material and a second material, wherein the second material is configured to elute from the porous body in the subject, wherein the porous body is configured to expand from a compressed state to an expanded state when the porous body is heated above a temperature threshold of 30° ° C. or 35° C. by body heat, wherein the porous body is connected to the distal end of the single tube via sutures or an adhesive, and wherein each branch of the plurality of branches rests in a corresponding channel of a plurality of channels of the porous body.

13. The medical system of claim 12 , wherein the porous body is coated with silver nanoparticles.

14. The medical system of claim 12 , wherein a size of the plurality of openings is approximately 50 μm to approximately 1 mm in diameter.

15. The medical system of claim 12 , wherein the first material includes a thermoresponsive material.

16. A medical system comprising:
a single tube defining a lumen, wherein the single tube includes a plurality of branches at a distal end of the single tube; and
a porous body fixed to the distal end of the single tube and configured to be advanced to a target site within a subject, wherein the porous body defines a plurality of openings, wherein the plurality of openings are in fluid connection with the lumen, wherein the porous body includes a first material and a second material, wherein the second material is configured to elute from the porous body in the subject, wherein the first material is responsive to a pH of the body to transition the porous body from a compressed state to an expanded state, wherein the porous body is at a distalmost end of the medical system, and wherein each branch of the plurality of branches rests in a corresponding channel of a plurality of channels of the porous body.

17. The medical system of claim 16 , wherein the first material is a polymer, wherein the second material includes a growth factor and an antibiotic, and wherein the first material and the second material are mixed together.

18. The medical system of claim 16 , wherein the distal end of the single tube is positioned within a recess of the porous body and is fixed to the porous body via sutures or an adhesive.

19. The medical system of claim 16 , wherein a distalmost end of the single tube is proximal to a distalmost end of the porous body.

20. The medical system of claim 4 , further comprising a catheter configured to supply the fluid to the porous body to transition the porous body from the compressed state to the expanded state.

Assignees

• Boston Scient Scimed Inc

Inventors

• Burke Martin
• Tuck Daniel
• Favreau John T
• Lydecker Lauren

Classifications

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L2300/414

  Growth factors · CPC title

• A61L2300/406

  Antibiotics · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61L31/125

  having a macromolecular matrix · CPC title