Zwitterionic hydrogels for delivery of biomolecules

Patent metadata

Field	Value
Publication number	US-12064534-B2
Application number	US-202217695964-A
Country	US
Kind code	B2
Filing date	Mar 16, 2022
Priority date	Jul 8, 2014
Publication date	Aug 20, 2024
Grant date	Aug 20, 2024

Abstract

The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. The invention represents a conceptual advance and enables a novel strategy for the utilization of zwitterionic motifs as therapeutics delivery vehicles and tissue engineering scaffolds.

First claim

What is claimed is:

1. An implant consisting of a crosslinked 3-dimensioanl zwitterionic polymer and a protein, wherein the protein is encapsulated in the crosslinked 3-dimensional zwitterionic polymer and is characterized by preserved bioactivity as sequestered, wherein the crosslinked 3-dimensional zwitterionic polymer is polymethacrylate, polyacrylate, polymethacrylamide, or polyacrylamide crosslinked with poly (ethylene glycol) dimethacrylate, poly(ethylene glycol) diacrylate, ethylene glycol diacrylate, or ethylene glycol dimethacrylate.

2. The implant of claim 1 , wherein the protein is a therapeutic osteogenic protein.

3. The implant of claim 1 , wherein the protein is an anabolic agent.

4. The implant of claim 1 , wherein the protein is an angiogenic factor.

5. The implant of claim 1 , wherein the zwitterionic moiety comprises one or more selected from sulfobetaine, phosphorylcholine and carboxybetaine.

6. The implant of claim 5 , wherein the zwitterionic moiety is present in the polymer network as pendant groups to a polymeric backbone.

7. The impant of claim 6 , wherein the zwitterionic moiety is present in the polymer at a density from about 0.05 mol % to about 10 mol %.

8. The implant of claim 1 , wherein the polymer is characterized by a crosslinking density, from about 0.05 mol % to about 10 mol %.

9. The method of claim 1 , wherein the implant is biodegradable.

10. The implant of claim 1 , suitable for implant as a dental implant or bone implant.

Assignees

• Univ Massachusetts

Inventors

• Song Jie
• Liu Pingsheng

Classifications

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title

• A61L27/52

  Hydrogels or hydrocolloids · CPC title

• A61L27/18

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L27/14

  Macromolecular materials · CPC title