System and method for solvent mixing in a chromatography system

US12059659B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-12059659-B2
Application numberUS-202117241255-A
CountryUS
Kind codeB2
Filing dateApr 27, 2021
Priority dateApr 29, 2020
Publication dateAug 13, 2024
Grant dateAug 13, 2024

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

A solvent mixing system includes a mixing tee, a centrifugal mixing path, and a low frequency blending mixer. The mixing tee has at least two solvent input ports and a solvent output port in fluid communication with one another. The centrifugal mixing path has a mixing path inlet in fluid communication with the solvent output port of the mixing tee. The centrifugal mixing path includes at least one coiled segment between the mixing path inlet and a mixing path outlet. The low frequency blending mixer is in fluid communication with the outlet of the centrifugal mixing path.

First claim

Opening claim text (preview).

What is claimed is: 1. A solvent mixing system comprising: a mixing tee having at least two solvent input ports and a solvent output port in fluid communication with one another; a centrifugal mixing path having a mixing path inlet in fluid communication with the solvent output port of the mixing tee, the centrifugal mixing path including at least one coiled segment between the mixing path inlet and a mixing path outlet; and a low frequency blending mixer in fluid communication with the outlet of the centrifugal mixing path, wherein the low frequency blending mixer is a single inlet mixer and comprises: a mixer input port in fluid communication with the outlet of the centrifugal mixing path; a first filter/retainer located downstream of the mixer input port; a mixing chamber; and a second filter/retainer located downstream of the mixing chamber. 2. The solvent mixing system of claim 1 , wherein the mixing tee has an internal mixing volume of about 0.045 uL. 3. The solvent mixing system of claim 1 , wherein the mixing tee is a low volume first in first out (FIFO) mixing point. 4. The solvent mixing system of claim 1 , wherein the mixing tee eliminates stratification of at least two solvent flow streams. 5. The solvent mixing system of claim 1 , wherein the centrifugal mixing path is contoured and shaped to impart a centrifugal force to a high velocity solvent mixture passing between the mixing path inlet and the mixing path outlet at a velocity between about 150 to 17,000 inch/min. 6. The solvent mixing system of claim 1 , wherein the centrifugal mixing path has an inner diameter between about 0.0005 to 0.090 inches. 7. The solvent mixing system of claim 1 , wherein the mixing chamber is a bead packed mixing chamber. 8. The solvent mixing system of claim 1 , wherein the mixing chamber is a diffusion bonded mixing chamber.

Assignees

Inventors

Classifications

  • Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application · CPC title

  • Filtering the mixture · CPC title

  • Filtering materials · CPC title

  • using driven stirrers · CPC title

  • Numerical speed values · CPC title

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What does patent US12059659B2 cover?
A solvent mixing system includes a mixing tee, a centrifugal mixing path, and a low frequency blending mixer. The mixing tee has at least two solvent input ports and a solvent output port in fluid communication with one another. The centrifugal mixing path has a mixing path inlet in fluid communication with the solvent output port of the mixing tee. The centrifugal mixing path includes at least…
Who is the assignee on this patent?
Waters Technologies Corp
What technology area does this patent fall under?
Primary CPC classification B01F29/15. Mapped technology areas include Operations & Transport.
When was this patent published?
Publication date Tue Aug 13 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).