Membrane for blood purification

Patent metadata

Field	Value
Publication number	US-12059658-B2
Application number	US-202318143325-A
Country	US
Kind code	B2
Filing date	May 4, 2023
Priority date	Feb 6, 2014
Publication date	Aug 13, 2024
Grant date	Aug 13, 2024

Abstract

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

First claim

The invention claimed is:

1. A membrane comprising an asymmetric finger-like structure comprising at least three layers, wherein the first layer is a separation layer, wherein the second layer is a sponge structure, and wherein the third layer is a finger structure,
wherein the membrane comprises i) at least one hydrophobic polymer component and ii) at least one hydrophilic polymer component, wherein the membrane has a molecular retention onset (MWRO) of between 9.0 kDa and 14.0 kDa and a molecular weight cut-off (MWCO) of between 55 kDa and 130 kDa as determined by dextran sieving before blood contact of the membrane, and
wherein the separation layer comprises pores.

2. The membrane of claim 1 , wherein the pores have an average radius, before blood or plasma contact, between 5.0 nm and 7.0 nm.

3. The membrane of claim 1 , wherein the pores have an average radius, before blood or plasma contact, between 5.0 nm and 6.7 nm.

4. The membrane of claim 1 , wherein the hydrophobic polymer component is poly(aryl)ethersulfone (PAES).

5. The membrane of claim 1 , wherein the hydrophilic polymer component is polyvinylpyrrolidone (PVP).

6. The membrane of claim 1 , wherein the hydrophobic polymer component is poly(aryl)ethersulfone (PAES) and the hydrophilic polymer component is polyvinylpyrrolidone (PVP), and
wherein the membrane comprises between 2.0 wt.-% to 4.0 wt.-% PVP and a balance of poly(aryl)ethersulfone adding up to 100%.

7. The membrane of claim 4 , wherein the membrane comprises a second hydrophobic polymer component.

8. The membrane of claim 7 , wherein the second hydrophobic polymer component is polyamide.

9. The membrane of claim 1 , wherein the separation layer has a thickness of less than about 0.5 μm.

10. The membrane of claim 1 , wherein the second layer has a thickness of about 1 μm to 15 μm.

11. The membrane of claim 1 , wherein the third layer has a thickness of 20 μm to 30 μm.

12. The membrane of claim 1 , wherein the membrane has a molecular retention onset (MWRO) of between 9.0 kDa and 12.5 kDa and a molecular weight cut-off (MWCO) of between 68 kDa and 110 kDa as determined by dextran sieving before blood contact of the membrane.

13. The membrane of claim 1 , wherein the membrane has a molecular retention onset (MWRO) of between 10.0 kDa and 12.5 kDa and a molecular weight cut-off (MWCO) of between 68 kDa and 90 kDa as determined by dextran sieving before blood contact of the membrane.

14. The membrane of claim 1 , wherein the membrane has a molecular retention onset (MWRO) of between 10.0 kDa and 12.5 kDa and a molecular weight cut-off (MWCO) of between 65 kDa and 90 kDa as determined by dextran sieving before blood contact of the membrane.

15. The membrane of claim 1 , wherein the membrane has an average sieving coefficient for albumin of between 0.02 and 0.1.

16. The membrane of claim 1 , wherein the membrane has an average sieving coefficient for albumin of between 0.02 and 0.08.

17. The membrane of claim 1 , wherein the membrane has an average sieving coefficient for albumin of between 0.01 and 0.1.

18. The membrane of claim 1 , wherein the membrane has an average sieving coefficient for albumin of between 0.01 and 0.06.

19. The membrane of claim 1 , wherein the membrane further comprises a fourth layer, wherein the fourth layer is an outer surface.

20. The membrane of claim 1 , wherein the fourth layer has a thickness of about 1 μm to 10 μm.

Assignees

• Gambro Lundia Ab

Inventors

• Boschetti-De-Fierro Adriana
• Voigt Manuel
• Krause Bernd
• Hornung Markus
• Storr Markus
• Behr Heinrich
• Beck Werner
• Zweigart Carina
• Buck Reinhold
• Herbst Philipp
• Loercher Joachim
• Wochner Arnd

Classifications

• B01D2325/04

  Characteristic thickness · CPC title

• B01D2325/026

  Sponge structure · CPC title

• B01D2325/025

  Finger pores · CPC title

• B01D69/081

  characterised by the fibre diameter · CPC title

• B01D61/243

  Dialysis · CPC title