Methods for injecting fluids

Patent metadata

Field	Value
Publication number	US-12048833-B2
Application number	US-201916730714-A
Country	US
Kind code	B2
Filing date	Dec 30, 2019
Priority date	Dec 29, 2014
Publication date	Jul 30, 2024
Grant date	Jul 30, 2024

Abstract

An instrument head including an exit opening ( 23 ), a first feed line ( 11 ) for feeding a first fluid, a second feed line ( 12 ) for feeding a second fluid, and a reservoir ( 24 ) for storing the second fluid fed via the second feed line ( 12 ) is disclosed. The reservoir ( 24 ) is in fluid communication with the first feed line ( 11 ) and/or is adapted to be brought in fluid communication with the first feed line ( 11 ) via at least a valve ( 25 ) arranged in the instrument head, to deliver the second fluid stored in the reservoir ( 24 ) via the exit opening ( 23 ).

First claim

What is claimed is:

1. A method for injection of liquids with a fluid jet applicator, the method comprising:
creating a canal in a tissue by expelling a first pulse of only a first fluid at a first pressure from a nozzle of the fluid jet applicator into the tissue; and
delivering a first pulse of a second fluid at a second pressure into the canal in the tissue created by the first pulse of the first fluid, wherein the second pressure is lower than the first pressure and the second fluid is different from the first fluid.

2. The method of claim 1 , further comprising delivering the first pulse of the second fluid using a second pulse of the first fluid to propel the second fluid.

3. The method of claim 1 , wherein the first pressure is at least twice as large as the second pressure.

4. The method of claim 1 , further comprising creating the canal and delivering the first pulse of the second fluid into the canal within a time interval of less than two seconds.

5. The method of claim 4 , wherein the time interval is less than 1 second.

6. The method of claim 1 , wherein the second fluid contains cells.

7. The method of claim 6 , wherein the second pressure is a quantity effective to prevent damage to the cells in the second fluid.

8. The method of claim 1 , wherein the first pressure is between 40 and 100 bar.

9. The method of claim 1 , wherein the first pressure is between 60 and 90 bar.

10. The method of claim 1 , wherein the second pressure is between 1 and 40 bar.

11. The method of claim 1 , wherein the second pressure is between 2 and 20 bar.

12. The method of claim 1 , wherein the tissue is a gastrointestinal wall, and delivering the first pulse of the second fluid into the canal includes delivering the first pulse of the second fluid to a muscularis.

13. The method of claim 1 , further comprising delivering a second pulse of the second fluid at a third pressure into the canal in the tissue created by the first pulse of the first fluid, wherein the third pressure is lower than the first pressure.

14. The method of claim 1 , further comprising raising a pressure of the first fluid prior to expelling the first pulse of the first fluid at the first pressure.

15. The method of claim 14 , further comprising operating a pump fluidly connected with the fluid jet applicator with a control valve downstream of the pump in a closed configuration to raise the pressure of the first fluid prior to expelling the first pulse of the first fluid; and
opening the control valve to expel the first pulse of the first fluid at the first pressure.

16. The method of claim 1 , further comprising terminating the first pulse of the first fluid by closing a control valve fluidly connected with the fluid jet applicator.

17. The method of claim 16 , further comprising opening a bypass downstream of the control valve to reduce a pressure of the first fluid within the fluid jet applicator.

18. The method of claim 1 , further comprising, after expelling the first pulse of the first fluid, lowering a pressure of the first fluid prior to delivering the first pulse of the second fluid at the second pressure.

Assignees

• Erbe Elektromedizin

Inventors

• Fech Andreas
• Fischer Klaus
• Blobel Lars
• Wandel Waldemar
• Enderle Markus

Classifications

• A61M5/16827

  controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths (infusion of multiple fluids without using a controller A61M5/1407) · CPC title

• A61M2005/1787

  Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid · CPC title

• A61M2205/50

  with microprocessors or computers · CPC title

• A61M5/204

  connected to external reservoirs for multiple refilling · CPC title

• A61M2005/3128

  Incorporating one-way valves, e.g. pressure-relief or non-return valves · CPC title