Devices, systems, and methods for performing optical and electrochemical assays

Patent metadata

Field	Value
Publication number	US-12038403-B2
Application number	US-202117343056-A
Country	US
Kind code	B2
Filing date	Jun 9, 2021
Priority date	Aug 17, 2017
Publication date	Jul 16, 2024
Grant date	Jul 16, 2024

Abstract

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

First claim

We claim:

1. A system for performing multiple assays on a biological sample, comprising:
an analyzer comprising: a cartridge port for mating with a test cartridge, a multi-terminal connector, a processor, memory coupled to the processor, and universal channel circuitry, wherein the universal channel circuitry comprises a first channel, a second channel, and a third channel;
a first test cartridge comprising a light emitter connected to a first contact and a light detector connected to a second contact; and
a second test cartridge comprising an amperometric electrode connected to a third contact and a reference electrode connected to a fourth contact,
wherein the first contact is electrically connectable to a first pin of the multi-terminal connector, and the second contact is electrically connectable to a second pin of the multi-terminal connector;
wherein the third contact is electrically connectable to the first pin of the multi-terminal connector, and the fourth contact is electrically connectable to the second pin of the multi-terminal connector;
wherein the first pin is electrically connectable to the first channel, and the second pin is electrically connectable to the second channel;
wherein when the first test cartridge is inserted into the cartridge port of the analyzer, the first channel comprises circuitry including switches that are arranged such that the first channel is configured in a current driver mode, and the second channel comprises circuitry including switches that are arranged such that the second channel is configured in a current measurement mode; and
wherein when the second test cartridge is inserted into the cartridge port of the analyzer, the first channel is configured in an amperometric measurement mode, and the second channel is configured in a reference measurement mode.

2. The system of claim 1 , wherein the processor is configured to convert an output signal received from the first test cartridge or the second test cartridge to an analyte signal.

3. The system of claim 2 , wherein the processor is further configured to determine a qualitative, semi-quantitative, or quantitative value proportional to an amount of a target analyte in the biological sample based on the analyte signal.

4. The system of claim 1 , further comprising an application-specific integrated circuit, wherein the universal channel circuitry is included within the application-specific integrated circuit.

5. The system of claim 4 , wherein the application-specific integrated circuit comprises an analog to digital signal converter.

6. The system of claim 1 , wherein the first test cartridge further comprises a conduit, an analyte assay region comprising a portion of the conduit, and a mirrored reflector that reflects light from the light emitter through the portion of the conduit to the light detector.

7. The system of claim 6 , wherein the mirrored reflector is at least a portion of a surface of the conduit.

8. The system of claim 1 , wherein the first test cartridge further comprises a sample receiving chamber, a conduit fluidically connected to the sample receiving chamber and comprising an analyte assay region, and a filter between the sample receiving chamber and the conduit, wherein the filter is configured to retain cells from a biological sample.

9. The system of claim 1 , wherein the cartridge port is configured to receive the first test cartridge and the second test cartridge sequentially.

10. The system of claim 1 , wherein the first test cartridge comprises a reactant and/or a substrate for a target analyte, and wherein the second test cartridge comprises a reagent for an electrochemical assay for a target analyte.

11. A system for performing multiple assays on a biological sample, comprising:
an analyzer comprising: a port, a multi-terminal connector, a processor, and universal channel circuitry, wherein the universal channel circuitry comprises a first channel, a second channel, and a third channel; and
a test cartridge comprising a light emitter connected to a first contact, a light detector connected to a second contact, and an amperometric electrode connected to a third contact,
wherein the first contact is electrically connectable to a first pin of the multi-terminal connector, the second contact is electrically connectable to a second pin of the multi-terminal connector, and the third contact is electrically connectable to a third pin of the multi-terminal connector;
wherein the first pin is electrically connectable to the first channel, the second pin is electrically connectable to the second channel, and the third pin is electrically connectable to the third channel; and
wherein the first channel comprises circuitry including switches that are arranged such that the first channel is configured in a current driver mode, the second channel comprises circuitry including switches that are arranged such that the second channel is configured in a current measurement mode, and the third channel comprises circuitry including switches that are arranged such that the third channel is configured in an amperometric measurement mode.

12. The system of claim 11 , wherein the processor is configured to convert an output signal received from the light detector to an analyte signal.

13. The system of claim 12 , wherein the processor is further configured to determine a qualitative, semi-quantitative, or quantitative value proportional to an amount of a target analyte in the biological sample based on the analyte signal.

14. The system of claim 11 , wherein the test cartridge further comprises a conduit, an analyte assay region comprising a portion of the conduit, and a mirrored reflector that reflects light from the light emitter through the portion of the conduit to the light detector.

15. The system of claim 14 , wherein the mirrored reflector is at least a portion of a surface of the conduit.

16. The system of claim 11 , the test cartridge further comprises a sample receiving chamber, a conduit fluidically connected to the sample receiving chamber and comprising an analyte assay region, and a filter between the sample receiving chamber and the conduit, wherein the filter is configured to retain cells from a biological sample.

17. The system of claim 11 , further comprising an application-specific integrated circuit, wherein the universal channel circuitry is included within the application-specific integrated circuit.

18. The system of claim 17 , wherein the application-specific integrated circuit comprises an analog to digital signal converter.

19. The system of claim 11 , wherein the test cartridge comprises a reactant and/or a substrate for a target analyte.

Assignees

• Abbott Point Of Care Inc

Inventors

• Low Michael Louie
• Bass Barry
• Gershtein Sergey

Classifications

• G01N27/3273

  Devices therefor, e.g. test element readers, circuitry (details not specific to biochemical electrodes G01N33/4875) · CPC title

• G01N27/3272

  Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels (optical biosensors G01N33/52) · CPC title

• G01N21/78

  producing a change of colour · CPC title

• G01N21/3151

  using two sources of radiation of different wavelengths (G01N21/33 - G01N21/39 take precedence) · CPC title

• B01L2200/0605

  Metering of fluids · CPC title