Device and method for producing microstructures

Patent metadata

Field	Value
Publication number	US-12036705-B2
Application number	US-202017636996-A
Country	US
Kind code	B2
Filing date	Aug 18, 2020
Priority date	Aug 22, 2019
Publication date	Jul 16, 2024
Grant date	Jul 16, 2024

Abstract

A device for producing microstructures, particularly microneedles and more particularly microneedle arrays, including a female mold that has, on a top side, at least one in particular conical depressed portion for producing a microstructure. The female mold is, for example, in the form of a silicone cap and is connected to a hollow cylinder, in particular via a holding element. A plunger is disposed movably inside the hollow cylinder.

First claim

The invention claimed is:

1. Device for producing microstructures, comprising:
a female mold comprising at least one preferably conical cavity at an upper side thereof for producing a microstructure, and an inner side opposite the upper side,
a base element comprising a hollow cylinder,
a holding element, which is connected to the female mold, for holding the female mold at the hollow cylinder such that the female mold spans an opening of the hollow cylinder, and
a plunger arranged in the hollow cylinder and displaceable in the longitudinal direction of the hollow cylinder, wherein an upper side of the plunger rests on the inner side of the female mold.

2. Device according to claim 1 , wherein the holding element comprises or is connected to a connecting element for a positive connection to the hollow cylinder.

3. Device according to claim 1 , wherein the holding element surrounds the hollow cylinder.

4. Device according to claim 1 , wherein the holding element rests on an inner side of the hollow cylinder completely in the circumferential direction.

5. Device according to claim 2 , wherein a gap is formed between the holding element and the hollow cylinder.

6. Device according to claim 1 , wherein the plunger has a planar upper side which, in an inserted position, rests on a lower side of the female mold.

7. Device according to claim 1 , wherein the base element comprises a plurality of hollow cylinders.

8. Device according to claim 1 , wherein a plurality of plungers is provided, which plungers are connected to one another via a connecting plate.

9. The Device according to claim 1 , wherein the holding element, and the female mold are formed in one piece therewith.

10. The Device according to claim 7 , wherein the plurality of hollow cylinders are connected to one another.

11. Method for producing microstructures with a device according to claim 1 , the method comprising the steps of:
inserting the at least one plunger into at least one hollow cylinder respectively, so that an upper side of the at least one plunger rests on a lower side of the female mold,
filling the at least one cavity of the female mold with a formulation,
retracting the plunger, and
removing a microstructure after the curing thereof.

12. Method according to claim 11 , wherein the at least one plunger is inserted such that the intermediate element is elongated and the female mold is lifted off from an edge surrounding the opening of the hollow cylinder.

13. Method according to claim 11 , wherein, when the at least one plunger is retracted, the intermediate element shortens or contracts, so that the lower side of the female mold rests on the edge of the hollow cylinder surrounding the opening.

14. Method according to claim 11 , wherein, if a plurality of female molds is present, these are, either individually one after the other, all together or in groups, lifted off by the at least one plunger and filled subsequently.

15. Method according to claim 11 , wherein the at least one female mold is filled with a formulation via a dosing means.

Assignees

• Lts Lohmann Therapie Systeme Ag

Inventors

• Kulik Michael
• Tissin Nikolaj

Classifications

• B29L2031/756

  Microarticles, nanoarticles · CPC title

• B29L2031/7544

  Injection needles, syringes · CPC title

• B29C43/021

  characterised by the shape of the surface · CPC title

• B29K2995/0094

  Geometrical properties · CPC title

• A61M2037/0046

  Solid microneedles · CPC title