Transdermal drug delivery patch and manufacturing method thereof

Patent metadata

Field	Value
Publication number	US-12036378-B2
Application number	US-201817055653-A
Country	US
Kind code	B2
Filing date	May 18, 2018
Priority date	May 18, 2018
Publication date	Jul 16, 2024
Grant date	Jul 16, 2024

Abstract

A transdermal drug delivery patch according to an exemplary embodiment of the present invention includes: a flexible base layer; and a plurality of microneedle disposed at one surface of the base layer. Each of the plurality of microneedles includes a biodegradable polymer and a drug and has an empty space inside. Each of the plurality of microneedles is formed as a star-shaped pyramid including a plurality of protrusions extending in a radial direction, and a part between two protrusions adjacent along the circumferential direction among the plurality of protrusions is concave.

First claim

The invention claimed is:

1. A manufacturing method of a transdermal drug delivery patch, comprising:
manufacturing a master mold including a transparent plate and a plurality of protruded parts disposed at one surface of the transparent plate and made of a star-shaped pyramid including a plurality of protrusions extending in a radial direction;
manufacturing a mold including a plurality of recess portions having a shape corresponding to a plurality of protruded parts by using the master mold; and
manufacturing a transdermal drug delivery patch including a base layer and a plurality of microneedles having a shape corresponding to a plurality of recess portions while having an empty space inside by using the mold, and a drug and a biodegradable polymer solution,
wherein the empty space of each of the plurality of microneedles is a star-shaped pyramid including a plurality of protrusions extending in the radial direction.

2. The manufacturing method of the transdermal drug delivery patch of claim 1 , wherein
the manufacturing of the master mold includes:
forming a photo-curable polymer layer on a transparent plate;
disposing a grayscale mask between a light source and the transparent plate; and
irradiating light to the photo-curable polymer layer through the grayscale mask for a process of curing a part of the photo-curable polymer layer.

3. The manufacturing method of the transdermal drug delivery patch of claim 2 , wherein
the grayscale mask includes a star-shaped light transmission part including a plurality of protrusions extending in a radial direction and a light blocking part other than the light transmission part, and
the light transmission rate of the light transmission part gets is smaller further away from the center of the light transmission part.

4. The manufacturing method of the transdermal drug delivery patch of claim 3 , wherein
the light transmission part is composed of a plurality of dots, and
the plurality of dots have a smaller size further away from the center of the light transmission part.

5. The manufacturing method of the transdermal drug delivery patch of claim 3 , wherein
the light transmission part is composed of a plurality of dots with the same size, and
the further away from the center of the light transmission part, the greater the distance between the plurality of dots.

6. The manufacturing method of the transdermal drug delivery patch of claim 1 , wherein
the manufacturing of the mold includes
coating a polymer solution on the master mold to form a polymer layer; and
applying heat to the polymer layer to be cured.

7. The manufacturing method of the transdermal drug delivery patch of claim 6 , wherein
before curing the polymer layer, a negative pressure is applied to the polymer layer to remove microbubbles included in the polymer layer.

8. The manufacturing method of the transdermal drug delivery patch of claim 1 , wherein
the manufacturing of the transdermal drug delivery patch includes:
filling a drug at each pointed end portion of a plurality of recess portions included in the mold;
coating a biodegradable polymer solution at the mold surface between each wall surface of a plurality of recess portions and the plurality of recess portions;
manufacturing the base layer and a plurality of microneedles by drying the drug and the biodegradable polymer solution; and
separating the base layer and the plurality of microneedles from the mold.

9. The manufacturing method of the transdermal drug delivery patch of claim 8 , wherein
before drying the drug and the biodegradable polymer solution,
a vacuum filter and a vacuum chamber are disposed at the rear of the mold, a vacuum pump connected to the vacuum chamber is operated, and
a negative pressure in a single direction is applied to the drug and the biodegradable polymer solution through the mold and the vacuum filter to remove microbubbles included in the drug and the biodegradable polymer solution.

10. The manufacturing method of the transdermal drug delivery patch of claim 1 , wherein
the manufacturing of the transdermal drug delivery patch includes:
coating a material solution in which a biodegradable polymer solution and a drug are mixed to each wall surface of the plurality of recess portions included in the mold;
coating the biodegradable polymer solution to the mold surface of the plurality of recess portions;
drying the material solution and the biodegradable polymer solution to manufacture the base layer and a plurality of microneedles; and
separating the base layer and the plurality of microneedles from the mold.

11. The manufacturing method of the transdermal drug delivery patch of claim 10 , wherein
before drying the material solution and the biodegradable polymer solution,
a vacuum filter and a vacuum chamber are disposed at the rear of the mold, a vacuum pump connected to the vacuum chamber is operated, and

a negative pressure of a single direction is applied to the material solution and the biodegradable polymer solution through the mold and the vacuum filter to remove microbubbles included in the material solution and the biodegradable polymer solution.

Assignees

• Postech Acad Ind Found
• Shilla Ind Co Ltd

Inventors

• Lim Geunbae
• Lee Jungho
• Choi Byoungsun
• Woo Hyeonsu

Classifications

• A61M2037/0053

  Methods for producing microneedles · CPC title

• A61M2037/0023

  Drug applicators using microneedles · CPC title

• A61K9/7046

  the adhesive comprising macromolecular compounds · CPC title

• A61K9/0021

  Intradermal administration, e.g. through microneedle arrays or needleless injectors · CPC title

• A61K9/703

  characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches · CPC title