Analyte sensor with impedance determination

Patent metadata

Field	Value
Publication number	US-12029560-B2
Application number	US-201916728765-A
Country	US
Kind code	B2
Filing date	Dec 27, 2019
Priority date	Dec 28, 2018
Publication date	Jul 9, 2024
Grant date	Jul 9, 2024

Abstract

Various examples are directed to systems and methods of and using analyte sensors. An example analyte sensor system comprises an analyte sensor and a hardware device in communication with the analyte sensor. The hardware device may be configured to perform operations comprising applying a first bias voltage to the analyte sensor, the first bias voltage less than an operational bias voltage of the analyte sensor, measuring a first current at the analyte sensor when the first bias voltage is applied, and applying a second bias voltage to the analyte sensor. The operations may further comprise measuring a second current at the analyte sensor when the second bias voltage is applied, detecting a plateau bias voltage using the first current and the second current, determining that the plateau bias voltage is less than a plateau bias voltage threshold, and executing a responsive action at the analyte sensor.

First claim

What is claimed is:

1. An analyte sensor system, comprising:
an analyte sensor comprising a working electrode and a reference electrode, the reference electrode comprising a material that is depleted during use of the analyte sensor; and
a hardware device in communication with the analyte sensor, wherein the hardware device is configured to perform operations comprising:
applying a first bias voltage to the working electrode of the analyte sensor, the first bias voltage less than an operational bias voltage of the working electrode of the analyte sensor;
measuring a first current at the analyte sensor when the first bias voltage is applied;
applying a second bias voltage to the working electrode of the analyte sensor;
measuring a second current at the analyte sensor when the second bias voltage is applied;
detecting a plateau bias voltage using the first current and the second current, wherein the plateau bias voltage is the bias voltage at which a current response stops;
determining if the plateau bias voltage is greater than a plateau bias voltage threshold; and
executing, in response to determining that the plateau bias voltage is greater than the plateau bias voltage threshold, a responsive action at the analyte sensor.

2. The analyte sensor system of claim 1 , wherein applying the first bias voltage and applying the second bias voltage comprises continuously sweeping the first bias voltage and the second bias voltage of the analyte sensor along a range including the first bias voltage and the second bias voltage.

3. The analyte sensor system of claim 1 , wherein detecting the plateau bias voltage comprises determining that the first current is less than a current threshold.

4. The analyte sensor system of claim 1 , the operations further comprising:
determining a current response of the analyte sensor using the first current and the second current, wherein detecting the plateau bias voltage comprises determining a bias voltage at which a slope of the current response is about zero.

5. The analyte sensor system of claim 1 , the operations further comprising:
determining stage of life data for the analyte sensor using the plateau bias voltage; and
displaying the stage of life data at a user interface.

6. The analyte sensor system of claim 1 , wherein the responsive action comprises applying a compensation to a third sensor current generated by the analyte sensor.

7. The analyte sensor system of claim 1 , wherein the responsive action comprises:
ceasing to provide a bias current to the analyte sensor; and
displaying at a user interface an indication that a sensor session for the analyte sensor is ended.

8. The analyte sensor system of claim 1 , wherein the analyte sensor is a glucose sensor.

9. The analyte sensor system of claim 1 , wherein the analyte sensor is a transcutaneous sensor.

10. A method of operating an analyte sensor, comprising:
applying a first bias voltage to a working electrode of the analyte sensor, the first bias voltage less than an operational bias voltage of the working electrode of the analyte sensor;
measuring a first current at the analyte sensor when the first bias voltage is applied;
applying a second bias voltage to the working electrode of the analyte sensor;
measuring a second current at the analyte sensor when the second bias voltage is applied;
detecting a plateau bias voltage using the first current and the second current;
determining if the plateau bias voltage is greater than a plateau bias voltage threshold; and
executing, in response to determining that the plateau bias voltage is greater than the plateau bias voltage threshold, a responsive action at the analyte sensor.

11. The method of claim 10 , wherein applying the first bias voltage and applying the second bias voltage comprises continuously sweeping the first bias voltage and the second bias voltage of the analyte sensor along a range including the first bias voltage and the second bias voltage.

12. The method of claim 10 , wherein detecting the plateau bias voltage comprises determining that the first current is less than a current threshold.

13. The method of claim 10 , further comprising:
determining a current response of the analyte sensor using the first current and the second current, wherein detecting the plateau bias voltage comprises determining a bias voltage at which a slope of the current response is about zero.

14. The method of claim 10 , further comprising:
determining stage of life data for the analyte sensor using the plateau bias voltage; and
displaying the stage of life data at a user interface.

15. The method of claim 10 , wherein the responsive action comprises applying a compensation to a third sensor current generated by the analyte sensor.

16. The method of claim 10 , wherein the responsive action comprises:
ceasing to provide a bias current to the analyte sensor; and
displaying at a user interface an indication that a sensor session for the analyte sensor is ended.

17. The method of claim 10 , wherein the analyte sensor is a glucose sensor.

18. The method of claim 10 , wherein the analyte sensor is a transcutaneous sensor.

Assignees

• Dexcom Inc

Inventors

• Bohm Sebastian
• Harley-Trochimczyk Anna Claire
• Rong Daiting
• Ma Rui
• Lan Wenjie
• Shi Minglian
• Sheth Disha B
• Kalfas Nicholas
• Crabtree Vincent P
• Turksoy Kamuran

Classifications

• A61F2007/0052

  for treatment of skin or hair · CPC title

• A61F2007/0093

  programmed · CPC title

• A61F2007/0071

  using a resistor, e.g. near the spot to be heated · CPC title

• A61B5/6844

  Monitoring or controlling distance between sensor and tissue · CPC title

• A61B5/1473

  invasive, e.g. introduced into the body by a catheter · CPC title