Lesion assessment by dielectric property analysis

Patent metadata

Field	Value
Publication number	US-12023091-B2
Application number	US-202117140198-A
Country	US
Kind code	B2
Filing date	Jan 4, 2021
Priority date	May 12, 2015
Publication date	Jul 2, 2024
Grant date	Jul 2, 2024

Abstract

Devices and methods for tissue lesion assessment and/or creation based on dielectric properties are disclosed. In some embodiments, one or more probing frequencies are delivered via electrodes including an electrode in proximity to a tissue (for example, myocardial tissue). Measured dielectric properties (such as impedance properties), optionally together with other known and/or estimated tissue characteristics, are used to determine the lesion state of the tissue. In some embodiments, a developing lesion state is monitored during treatment formation of a lesion (for example, ablation of heart tissue to alter electrical transmission characteristics).

First claim

What is claimed is:

1. A system for in vivo tissue assessment, the system comprising a computer processor and a memory storing instructions that instruct the processor to:
determine at least one dielectric property of a target tissue by combined analysis of electrical signals measured at a plurality of frequencies, each frequency measured using a plurality of intra-body positioned electrodes; and
estimate a tissue state of said target tissue, based on the determined at least one dielectric property.

2. The system of claim 1 , wherein the processor is configured to access the electrical signals, under instructions from the memory, as output from an electrical circuit comprising the plurality of electrodes, each of the plurality of electrodes being positioned at an intra-body position wherefrom the electrode acts in establishing an electrical field intersecting the target tissue.

3. The system of claim 2 , wherein the processor is instructed to estimate the tissue state based also on estimated anatomical information for tissue affecting the signal output.

4. The system of claim 1 , wherein the processor is instructed to access a data structure correlating dielectric properties with tissue states; and estimate the tissue state based also on the received data structure.

5. The system of claim 4 , wherein the data structure is obtained by machine learning methods.

6. The system of claim 4 , wherein said at least one dielectric property comprises a vector of dielectric parameter values, and the processor estimates the tissue state based on statistical correlation between vectors of dielectric parameter values and said tissue state, the statistical correlation being described by the data structure.

7. The system of claim 1 , wherein the processor is instructed to iteratively determine the at least one dielectric property of the target tissue by analysis of new electrical signal measurements indicative of changes in target tissue state during ablation of the target tissue, and iterative estimate the tissue state of the target tissue using the new electrical signal measurements.

8. The system of claim 7 , comprising an ablation controller, wherein the processor provides the tissue state estimate to the ablation controller, and the ablation controller uses the tissue state estimate as a parameter for control of tissue ablation.

9. The system of claim 8 , wherein the ablation controller operates at least one of said plurality of electrodes at the intra-body position to perform ablation.

10. The system of claim 8 , wherein the ablation controller is configured to reduce or terminate ablation based on the tissue state estimate indicating an elevated risk of an adverse event associated with ablation.

11. The system of claim 8 , wherein the ablation controller controls ablation to form a lesion in cardiac tissue for the treatment of atrial fibrillation.

12. The system of claim 8 , wherein the ablation controller adjusts ablation parameters in response to a series of the tissue state estimates so that a post-ablation tissue state estimate matches a target state of the target tissue after ablation.

13. A system for tissue assessment, comprising an analyzer module having a processor and computer memory storage;
wherein the computer memory storage stores a data structure correlating values of dielectric parameters of tissue with a tissue state;
wherein the computer memory storage includes instructions instructing the processor to:
access measurements of dielectric parameters of a target tissue, the dielectric parameters corresponding to measurements at a plurality of frequencies, and each frequency measured using a plurality of intra-body positioned electrodes,
access the stored data structure according to a vector of dielectric properties determined using the measurements of dielectric parameters, and
produce from them an estimate of a state of said target tissue.

14. The system of claim 13 , comprising an electrode on a probe configured for intrabody insertion to the target tissue, wherein the electrode is configured to measure the measurements of dielectric parameters.

15. The system of claim 13 , wherein the processor is also configured to access additional information relating to at least one from a group consisting of:
the anatomy of tissue influencing the measurements of the target tissue;
a position of the intra-body catheter; and
a position of a body surface electrode.

16. The system of claim 13 , comprising:
an ablation probe positionable to ablate a portion of said target tissue; and
an ablation controller,
wherein the processor is configured to provide the estimate of the state of said target tissue to the ablation controller; and

wherein the ablation controller is configured to control ablation by the ablation probe based on said estimated state of the target tissue.

17. The system of claim 16 , comprising an electrode on an intra-body probe used to measure the measurements of dielectric parameters, which also acts as the ablation probe.

18. The system of claim 13 , comprising an electrical field measurement device configured to measure parameters of an output signal of an electrical circuit comprising at least one electrode positioned within the target tissue, including measurements of the values of dielectric parameters of said target tissue.

19. A system for assessment of a target tissue, comprising:
an electrical field measurement device configured to measure parameters of an output signal of an electrical circuit comprising at least one electrode and said target tissue, measurements of said output signal parameters including measurements of the values of dielectric parameters of a target tissue, the measurements being made at a plurality of frequencies, and each frequency measured using a plurality of intra-body positioned electrodes; and
an analyzer module, including a data structure correlating vectors of values of dielectric parameters of tissue with a tissue state;
wherein the analyzer module is configured to receive said measurements of dielectric parameters of said target tissue, and to produce from them an estimate of a state of said target tissue, based on said data structure.

20. The system of claim 19 , comprising at least one electrode on an intra-body catheter, positionable to be in proximity to the target tissue.

Assignees

• Navix Int Ltd

Inventors

• Schwartz Yitzhack
• Shmayahu Yizhaq
• Dichterman Eli

Classifications

• A61B2018/00875

  Resistance or impedance · CPC title

• A61B2018/00761

  Duration · CPC title

• A61B2018/00738

  Depth, e.g. depth of ablation · CPC title

• A61B2018/00642

  with feedback, i.e. closed loop control · CPC title

• A61B2018/00577

  Ablation · CPC title