Nutritional composition, food/drink composition using nutritional composition, and modified milk powder using nutritional composition

Patent metadata

Field	Value
Publication number	US-12022844-B2
Application number	US-201916975778-A
Country	US
Kind code	B2
Filing date	Mar 26, 2019
Priority date	Mar 29, 2018
Publication date	Jul 2, 2024
Grant date	Jul 2, 2024

Abstract

Provided is a method that makes it possible to promote proliferation of probiotics having a low ability to assimilate human milk oligosaccharides (HMOs), in the presence of HMOs. A nutritional composition is described that includes bacteria belonging to Bifidobacterium bifidum, one or more types of probiotics having a low ability to assimilate human milk oligosaccharides, and human milk oligosaccharides. The nutritional composition as described herein may be suitably used for foods/drinks, medicines, quasi-drugs, feeds, and the like.

First claim

The invention claimed is:

1. A nutritional composition comprising:
bacteria belonging to Bifidobacterium bifidum;
one or more types of probiotics having a low ability to assimilate human milk oligosaccharides; and
human milk oligosaccharides;

wherein the probiotics are a bacterium strain selected from the group consisting of Bifidobacterium longum subspecies longum ATCC15707 , Bifidobacterium longum subspecies longum BB536 , Bifidobacterium adolescentis ATCC15703, Bifidobacterium pseudocatenulatum ATCC27919, Bifidobacterium animalis subspecies lactis DSM10140 , Bifidobacterium animalis subspecies lactis MCC-525 , Bifidobacterium breve ATCC15700, Bifidobacterium pseudolongum ATCC25526, Bifidobacterium longum (FERM P-10657), Bifidobacterium animalis subspecies lactis Bb-12 DSM1595 , Bifidobacterium animalis subspecies lactis GCL2505 , Bifidobacterium animalis subspecies lactis CNCMI-2494 , Bifidobacterium animalis subspecies lactis LAFTI B94 , Bifidobacterium animalis subspecies lactis, Bifidobacterium longum Rosell-175 , Bifidobacterium animalis subspecies animalis, Bifidobacterium animalis subspecies lactis HN019 , Lactobacillus paracasei ATCC25302, Lactobacillus plantarum ATCC14917, Lactobacillus acidophilus ATCC4356, Lactobacillus rhamnosus ATCC7469, Lactobacillus gasseri ATCC33323 , Lactobacillus gasseri FERM BP-10953 , Lactobacilluss gasseri FERM BP-6999 , Lactobacilluss gasseri , (NITE BP-224R), Lactobacillus delbrueckii subspecies bulgaricus (FERM P-17227), Lactobacillus rhamnosus ATCC53103, Lactobacillus reuteri DSM17938, Bacillus coagulans GBI-30 , Lactobacillus acidophilus, Lactobacillus acidophilus LAFTI L10 , Lactobacillus casei LAFTI L26 , Lactococcus lactis subspecies lactis Rosell-1058 , Lactobacillus paracasei NCC2461 , Lactobacillus johnsonii NCC533 , Lactobacillus rhamnosus Rosell-11 , Lactobacillus acidophilus Rosell-52 , Lactobacillus casei, Lactobacillus casei shirota, and combinations thereof.

2. The nutritional composition according to claim 1 , wherein the human milk oligosaccharides are 2′-fucosyllactose and/or lacto-N-neotetraose.

3. The nutritional composition according to claim 1 , wherein the bacteria belonging to Bifidobacterium bifidum are a bacterium selected from the group consisting of Bifidobacterium bifidum ATCC29521, Bifidobacterium bifidum (NITE BP-2429), Bifidobacterium bifidum (NITE BP-1252), Bifidobacterium bifidum (NITE BP-2431), Bifidobacterium bifidum (NITE BP-02648), Bifidobacterium bifidum (NITE BP-02432), Bifidobacterium bifidum (NITE BP-02433), and combinations thereof.

4. A food/drink composition comprising the nutritional composition described in claim 1 .

5. A modified milk powder comprising the nutritional composition described in claim 1 .

6. A method for promoting proliferation of probiotics having a low ability to assimilate human milk oligosaccharides in the presence of human milk oligosaccharides, the method comprising co-culturing the probiotics with Bifidobacterium bifidum and human milk oligosaccharides,
wherein the probiotics are a bacterium strain selected from the group consisting of Bifidobacterium longum subspecies longum ATCC15707 , Bifidobacterium longum subspecies longum BB536 , Bifidobacterium adolescentis ATCC15703, Bifidobacterium pseudocatenulatum ATCC27919, Bifidobacterium animalis subspecies lactis DSM10140 , Bifidobacterium animalis subspecies lactis MCC-525 , Bifidobacterium pseudolongum ATCC25526, Bifidobacterium longum (FERM P-10657), Bifidobacterium animalis subspecies lactis Bb-12 DSM1595 , Bifidobacterium animalis subspecies lactis GCL2505 , Bifidobacterium animalis subspecies lactis CNCMI-2494 , Bifidobacterium animalis subspecies lactis LAFTI B94 , Bifidobacterium animalis subspecies lactis, Bifidobacterium longum Rosell-175 , Bifidobacterium animalis subspecies animalis, Bifidobacterium animalis subspecies lactis HN019 , Lactobacillus paracasei ATCC25302, Lactobacillus plantarum ATCC14917, Lactobacillus acidophilus ATCC4356, Lactobacillus rhamnosus ATCC7469, Lactobacillus gasseri ATCC33323 , Lactobacillus gasseri FERM BP-10953 , Lactobacilluss gasseri FERM BP-6999 , Lactobacilluss gasseri , (NITE BP-224R), Lactobacillus delbrueckii subspecies bulgaricus (FERM P-17227), Lactobacillus rhamnosus ATCC53103, Lactobacillus reuteri DSM17938, Bacillus coagulans GBI-30 , Lactobacillus acidophilus, Lactobacillus acidophilus LAFTI L10 , Lactobacillus casei LAFTI L26 , Lactococcus lactis subspecies lactis Rosell-1058 , Lactobacillus paracasei NCC2461 , Lactobacillus johnsonii NCC533 , Lactobacillus rhamnosus Rosell-11 , Lactobacillus acidophilus Rosell-52 , Lactobacillus casei, Lactobacillus casei shirota , and combinations thereof.

7. The method according to claim 6 , wherein the human milk oligosaccharides are 2′-fucosyllactose and/or lacto-N-neotetraose.

8. The method according to claim 6 , wherein the bacteria belonging to Bifidobacterium bifidum are a bacterium strain selected from the group consisting of Bifidobacterium bifidum ATCC29521, Bifidobacterium bifidum (NITE BP-2429), Bifidobacterium bifidum (NITE BP-1252), Bifidobacterium bifidum (NITE BP-2431), Bifidobacterium bifidum (NITE BP-02648), Bifidobacterium bifidum (NITE BP-02432), Bifidobacterium bifidum (NITE BP-02433), and combinations thereof.

9. A method for promoting proliferation of probiotics having a low ability to assimilate human milk oligosaccharides in an intestine, the method comprising
administrating the nutritional composition according to claim 1 ,
wherein the probiotics have a low ability to assimilate human milk oligosaccharides in the nutritional composition.

Assignees

• Morinaga Milk Industry Co Ltd

Inventors

• Takahashi Sachiko
• Iwabuchi Noriyuki

Classifications

• A23C9/1307

  Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods · CPC title

• A23L33/40 Primary

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title

• A23L33/135

  Bacteria or derivatives thereof, e.g. probiotics · CPC title

• A23L33/125

  containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates (indigestible substances A23L33/21) · CPC title

• A23L29/30

  containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin (products from apiculture A23L21/20; artificial sweetening agents A23L27/30) · CPC title