Apparatus, method, and computer program product for adapting a predefined liquid chromatography process

Patent metadata

Field	Value
Publication number	US-12019058-B2
Application number	US-202217938618-A
Country	US
Kind code	B2
Filing date	Oct 6, 2022
Priority date	Feb 27, 2018
Publication date	Jun 25, 2024
Grant date	Jun 25, 2024

Abstract

The present invention relates to a liquid chromatography system configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process. The liquid chromatography system comprises a controller configured to: control the operation of the chromatography system to run the predefined process; retrieve column data accessible from a data storage, the column data being specific to each column; and adapt at least one process parameter of the predefined process for each column based on column data. Whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.

First claim

The invention claimed is:

1. A liquid chromatography system configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process, wherein the liquid chromatography system comprises a controller configured to:
control the operation of the chromatography system to run the predefined process,
retrieve column data accessible from a data storage, the column data being specific to each column, and
adapt at least one process parameter of the predefined process for each column based on column data,
whereby the controller comprises at least one sensor is configured to adapt at least one process parameter of the predefined process for each column based on column data, and
whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.

2. The liquid chromatography system according to claim 1 configured to operate with a single column for purification of the sample.

3. The liquid chromatography system according to claim 1 configured to operate with at least three columns for continuous purification of the sample.

4. The liquid chromatography system according to claim 1 , wherein each column is of a specific type and the data storage comprises historic data for each column and/or columns belonging to the same specific type previously used in the liquid chromatography system for purification of the sample, wherein the controller is configured to further adapt the at least one process parameter of the predefined process based on the historic data.

5. The liquid chromatography system according to claim 1 , wherein the data storage comprises column data related to production parameters when producing each column.

6. The liquid chromatography system according to claim 5 , wherein each column comprises a vessel for holding resin and the production parameters comprises, height of resin bed, pressure boundaries, flow specification, material properties, hardware specific properties, filter properties, and physical dimensions of the vessel.

7. The liquid chromatography system according to claim 6 , wherein the height of the resin bed is the actual height or the height of the vessel.

8. The liquid chromatography system according to claim 1 , further comprising sensors adapted to read sensor parameters, wherein the adaptation of the at least one process parameters further is based on sensor readings.

9. The liquid chromatography system according to claim 1 , wherein sensor readings comprises any of: UV, Flow and Pressure.

10. The liquid chromatography system according to claim 5 , wherein the production parameters further comprises actual volume of resin in each column.

11. The liquid chromatography system according to claim 1 , wherein the data storage is a database.

12. The liquid chromatography system according to claim 11 , wherein the database is integrated in the liquid chromatography system.

13. The liquid chromatography system according to claim 1 , wherein the data storage is integrated in each column.

14. A method for controlling a liquid chromatography system configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process, wherein the method comprises:
controlling the operation of the chromatography system to run the predefined process,
retrieving column data accessible from a data storage, the column data being specific to each column, and
adapting at least one process parameter of the predefined process for each column based on column data,
whereby the liquid chromatography system further comprises at least one sensor is configured to adapt at least one process parameter of the predefined process for each column based on column data, and
whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.

15. The method according to claim 14 , wherein each column is of a specific type and the data storage comprises historic data for each column and/or columns belonging to the same specific type previously used in the liquid chromatography system for purification of the sample, wherein the method comprises further adapting the at least one process parameter of the predefined process based on the historic data.

16. The method according to claim 14 , wherein the data storage comprises column data related to production parameters when producing each column, the production parameters comprises, height of resin bed, pressure boundaries, flow specification, material properties, hardware specific properties, filter properties, and physical dimensions of a vessel, wherein the method comprises further adapting the at least one process parameter of the predefined process based on the production parameters.

17. The method according to claim 14 , wherein the liquid chromatography system further comprises sensors adapted to read sensor parameters, wherein the method further comprises further adapting the at least one process parameter based on sensor readings.

18. The method according to claim 17 , wherein the method further comprises selecting the sensor readings to comprise any of: UV, Flow and Pressure.

19. The method according to claim 14 , wherein the data storage is selected to be a database.

20. The method according to claim 19 , further comprising integrating the database in the liquid chromatography system.

21. The method according to claim 14 , further comprising integrating the data storage in each column.

22. A computer program for controlling a liquid chromatography system, comprising instructions which, when executed on at least one processor, cause the at least one processor to carry out the method according to claim 14 .

23. A computer-readable storage medium carrying a computer program for controlling a liquid chromatography system according to claim 22 .

Assignees

• Cytiva Sweden Ab

Inventors

• Widehammar Jens
• Hyckenberg Key
• Grelsson Orjan
• Mattsson Lars
• Karlsson Kjell

Classifications

• B01D15/1885

  placed in parallel · CPC title

• B01D15/102

  Process control, e.g. determination or optimization of process parameters; Programmable logic control [PLC] · CPC title

• G01N2030/027

  Liquid chromatography · CPC title

• G01N30/8658 Primary

  Optimising operation parameters · CPC title