Pcna inhibitors
US-2024343682-A1 · Oct 17, 2024 · US
US12017975B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12017975-B2 |
| Application number | US-202217966227-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 14, 2022 |
| Priority date | Sep 5, 2018 |
| Publication date | Jun 25, 2024 |
| Grant date | Jun 25, 2024 |
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Provided herein are Myc-Max inhibitory compounds having the structure of Formula (I) and compositions thereof for use in the treatment of cancer. In particular, the Myc-Max inhibitory compounds may be useful for the treatment of cancers selected from one or more of: prostate cancer, breast cancer, colon cancer, cervical cancer, small-cell lung carcinomas, neuroblastomas, osteosarcomas, glioblastomas, melanoma and myeloid leukaemia.
Opening claim text (preview).
We claim: 1. A method of cancer treatment, the method comprising administering a compound having the structure to a patient in need thereof, wherein the cancer is selected from one or more of the following: prostate cancer; breast cancer; colon cancer; cervical cancer; small-cell lung carcinoma; neuroblastomas; osteosarcoma; glioblastoma; melanoma; and myeloid leukaemia. 2. The method of claim 1 , wherein the cancer is selected from prostate cancer, breast cancer, colon cancer, cervical cancer, and small-cell lung carcinoma. 3. The method of claim 1 , wherein the cancer is prostate cancer. 4. The method of claim 1 , wherein the cancer is breast cancer. 5. The method of claim 1 , wherein the cancer is colon cancer. 6. The method of claim 1 , wherein the cancer is cervical cancer. 7. The method of claim 1 , wherein the cancer is small-cell lung carcinoma. 8. The method of claim 1 , wherein the cancer is a neuroblastoma. 9. The method of claim 1 , wherein the cancer is an osteosarcoma. 10. The method of claim 1 , wherein the cancer is a glioblastoma. 11. The method of claim 1 , wherein the cancer is a melanoma. 12. The method of claim 1 , wherein the cancer is a myeloid leukaemia.
Ortho-condensed systems · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
linked by a carbon chain containing only aliphatic carbon atoms · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
linked by a carbon chain containing only aliphatic carbon atoms · CPC title
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