System and method for measuring fluid flow from a syringe

Patent metadata

Field	Value
Publication number	US-12013267-B2
Application number	US-202017622195-A
Country	US
Kind code	B2
Filing date	Jun 30, 2020
Priority date	Jul 1, 2019
Publication date	Jun 18, 2024
Grant date	Jun 18, 2024

Abstract

A device and method for measuring a volume of liquid expelled from a syringe is provided. The device generally includes a syringe barrel, a plunger actuated with a plunger rod, and a sensor. The sensor may include two ports with one port being in fluid communication with a source of fluid external to the syringe barrel, while the second port is in fluid communication either with a proximal end portion of the syringe barrel or a hollow plunger rod having a first end closed by the plunger. The method may include expelling liquid from the syringe; detecting and recording differential pressure with the sensor over time; and calculating the volume of liquid expelled from the syringe from the recorded differential pressure over time.

First claim

I claim:

1. A device comprising:
a syringe barrel having a proximal end portion and a distal end portion;
a plunger within the syringe barrel and configured to slide within the syringe barrel from the proximal end portion towards the distal end portion and provide a seal between the proximal end portion and the distal end portion; and
a sensor having a first and second port, the first port being in fluid communication with the proximal end portion and the second port being in fluid communication with a source of fluid external to the syringe barrel,
wherein the proximal end portion of the syringe barrel defines a barrier, a first internal volume is disposed between the plunger and the barrier, a second internal volume is disposed between the source of fluid external to the syringe barrel and the barrier, and the second internal volume is open to the source of fluid external to the syringe barrel, and
wherein the sensor is configured to operate with the second port in fluid communication with the source of fluid external to the syringe barrel via the second internal volume.

2. The device of claim 1 , wherein the sensor is a pressure differential sensor.

3. The device of claim 1 , further comprising a controller connected to the sensor and configured to record pressure differential readings detected by the sensor.

4. The device of claim 3 , wherein the distal end portion of the syringe barrel contains a liquid, and the controller is configured to calculate the total volume of liquid expelled from the syringe barrel from the pressure differential readings.

5. The device of claim 1 , wherein the source of fluid is ambient air.

6. The device of claim 1 , wherein the distal end portion of the syringe barrel is filled with a liquid.

7. The device of claim 6 , wherein the liquid contains a therapeutic agent.

8. The device of claim 1 , wherein the barrier is stationary, and the first port is in fluid communication at a point between the barrier and the plunger.

9. The device of claim 1 , further comprising an extension housing attached to the proximal end portion of the syringe barrel, the extension housing defining the barrier,
wherein the barrier is stationary, and the first port is in fluid communication at a point between the barrier and the plunger.

10. The device of claim 1 , further comprising a hollow plunger rod having a first end attached to the plunger, a second end in fluid communication with the first port, and an opening proximate to the plunger in fluid communication with the proximal end portion.

11. A method of measuring a volume of liquid expelled from the device according to claim 1 , wherein the device further comprises a liquid orifice in the distal end portion of the syringe barrel, the second internal volume of the syringe barrel being filled with a liquid, the method comprising:
sliding the plunger from the proximal end portion towards the distal end portion to expel liquid through the liquid orifice;
detecting and recording differential pressure with the sensor over time; and
calculating the volume of liquid expelled through the liquid orifice from the recorded differential pressure over time.

12. A device comprising:
a syringe barrel defining an internal volume between a proximal end portion and a distal end portion, the proximal end portion defining a barrier that at least partially seals the proximal end portion;
a plunger within the syringe barrel and configured to slide within the syringe barrel from the proximal end portion towards the distal end portion and to provide a seal between the proximal end portion and the distal end portion;
a sensor having a first and second port, the second port being in fluid communication with a source of fluid external to the syringe barrel; and
a hollow plunger rod having a first end closed by the plunger, a second end in fluid communication with the first port, and an opening in fluid communication with the proximal end portion.

13. The device of claim 12 , wherein the plunger is elastomeric.

14. The device of claim 12 , wherein the sensor is a pressure differential sensor.

15. The device of claim 12 , wherein the sensor is a barometric pressure sensor.

16. The device of claim 12 , further comprising a controller connected to the sensor and configured to record pressure differential readings detected by the sensor.

17. The device of claim 16 , wherein the distal end portion of the syringe barrel contains a liquid, and the controller is configured to calculate the total volume of liquid expelled from the syringe barrel from the pressure differential readings.

18. The device of claim 12 , wherein the source of fluid is ambient air.

19. The device of claim 12 , wherein the hollow plunger rod further comprises a thumb pad, and the sensor is housed within the thumb pad.

20. A method of measuring a volume of liquid expelled from the device according to claim 12 , wherein the device further comprises a liquid orifice in the distal end portion of the syringe barrel, the distal end portion of the internal volume of the syringe barrel being filled with a liquid, the method comprising:
sliding the plunger from the proximal end portion towards the distal end portion to expel liquid through the liquid orifice;
detecting and recording differential pressure with the sensor over time; and
calculating the volume of liquid expelled through the liquid orifice from the recorded differential pressure over time.

Assignees

• West Pharmaceutical Services Inc

Inventors

• Morrison Mark Steven

Classifications

• A61M5/486

  Indicating injection pressure · CPC title

• A61M5/3135

  characterised by constructional features of the proximal end · CPC title

• A61M5/31533

  Dosing mechanisms, i.e. setting a dose (administrating mechanisms A61M5/31565) · CPC title

• A61M2205/3334

  Measuring or controlling the flow rate · CPC title

• A61M2205/50

  with microprocessors or computers · CPC title