Method for producing porous metal oxide

Patent metadata

Field	Value
Publication number	US-12012337-B2
Application number	US-202318094542-A
Country	US
Kind code	B2
Filing date	Jan 9, 2023
Priority date	Jan 21, 2016
Publication date	Jun 18, 2024
Grant date	Jun 18, 2024

Abstract

Provided is a method for producing a porous metal oxide. The method includes: preparing a slurry by mixing a metal source, a pore forming agent and an aqueous solvent; drying the slurry to obtain a metal oxide precursor; and sintering the metal oxide precursor to generate a porous metal oxide. The metal source is an organometallic compound or hydrolyzate thereof containing a metal that makes up the porous metal oxide; the pore forming agent is an inorganic compound that generates a gas by decomposing at a temperature equal to or lower than a temperature at which the metal oxide precursor is sintered; and the slurry is prepared using 50 parts by weight or more of the pore forming agent with respect to 100 parts by weight of the metal source.

First claim

The invention claimed is:

1. A technetium 99m ( 99m Tc) generator, wherein the generator comprises a porous metal oxide as a molybdenum (Mo) absorbent, and the porous metal oxide has a pore volume of 0.3 cm 3 /g or larger and an average pore size of 9 nm or larger, wherein the porous metal oxide is porous titania, porous zirconia or porous alumina.

2. The generator of claim 1 , wherein the porous metal oxide has a specific surface area of 180 m 2 /g or larger.

3. The generator of claim 1 , wherein the porous metal oxide is porous alumina.

4. The generator of claim 1 , wherein the porous metal oxide is porous zirconia.

5. The generator of claim 1 , wherein the porous metal oxide has the pore volume of 0.3 cm 3 /g or larger and 1.153 cm 3 /g or smaller.

6. The generator of claim 1 , wherein the porous metal oxide has an average particle size of 1 μm or greater.

7. The generator of claim 1 , wherein a Mo held amount of Mo atoms held per gram of the porous metal oxide is 200 mg/g or higher.

8. A kit for preparation of a radiopharmaceutical, the kit comprising:
a technetium 99m ( 99m Tc) generator comprising a column and a porous metal oxide as a Mo absorbent packed in the column, wherein the porous metal oxide has a pore volume of 0.3 cm 3 /g or larger and an average pore size of 9 nm or larger;
an aqueous solution containing ( 99 Mo)O 4 2- ; and
an eluent, wherein the porous metal oxide is porous titania, porous zirconia or porous alumina.

9. The kit of claim 8 , wherein the porous metal oxide has a specific surface area of 180 m 2 /g or larger.

10. The kit of claim 8 , wherein the porous metal oxide has the pore volume of 0.3 cm 3 /g or larger and 1.153 cm 3 /g or smaller.

11. The kit of claim 8 , wherein the porous metal oxide has an average particle size of 1 μm or greater.

12. The kit of claim 8 , wherein a Mo held amount of Mo atoms held per gram of the porous metal oxide is 200 mg/g or higher.

13. The kit of claim 8 , wherein the radiopharmaceutical includes technetium 99m.

Assignees

• Fujimi Inc

Inventors

• Tsubota Shogo
• Hepburn Robert

Classifications

• C01P2006/16

  Pore diameter · CPC title

• C01P2006/14

  Pore volume · CPC title

• C01P2006/12

  Surface area · CPC title

• C01F7/36 Primary

  from organic aluminium salts · CPC title

• C01P2006/80

  Compositional purity · CPC title