Method of making a sensor device

Patent metadata

Field	Value
Publication number	US-12011265-B2
Application number	US-201916359765-A
Country	US
Kind code	B2
Filing date	Mar 20, 2019
Priority date	Oct 12, 2012
Publication date	Jun 18, 2024
Grant date	Jun 18, 2024

Abstract

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

First claim

What is claimed is:

1. A method of making a sensor device for measuring an analyte concentration in a host, the method comprising:
coating a wire with a membrane;
cutting the coated wire to a desired length to thereby form a sensor tip; and
exposing the coated wire to a hardening agent such that the membrane absorbs the hardening agent, whereby the sensor device is formed, the sensor device being configured to be inserted into skin of the host and configured to measure the analyte concentration within the skin of the host.

2. The method of claim 1 , wherein exposing the coated wire comprises dipping at least the sensor tip in the hardening agent.

3. The method of claim 1 , further comprising curing the membrane to harden the hardening agent.

4. The method of claim 1 , further comprising sharpening the sensor tip to form a sharp point capable of piercing tissue.

5. The method of claim 4 , wherein the sensor tip comprises a material that does not react with hydrogen peroxide.

6. The method of claim 4 , further comprising applying a deadening agent to the sharpened sensor tip to deaden any active surfaces exposed during the sharpening step.

7. The method of claim 6 , wherein the deadening agent comprises cyanoacrylate or silane.

8. The method of claim 6 , wherein the deadening agent is applied using vapor deposition.

9. The method of claim 4 , further comprising sharpening the membrane at the sensor tip.

10. The method of claim 4 , wherein the sharp point is exposed through the membrane.

11. The method of claim 1 , wherein the hardening agent provides increased column strength to the coated wire such that the coated wire is capable of being inserted through the skin of the host without substantial buckling.

12. The method of claim 1 , wherein the hardening agent increases adhesion of the membrane to the wire.

13. The method of claim 1 , wherein the hardening agent allows analyte permeability within the membrane.

14. The method of claim 1 , wherein the hardening agent promotes resistance to peeling of the membrane from the wire during insertion of the sensor device into the skin of the host.

15. The method of claim 1 , wherein the hardening agent comprises cyanoacrylate.

16. The method of claim 1 , wherein the hardening agent comprises an epoxy or an ultraviolet (UV) adhesive.

17. The method of claim 1 , wherein the hardening agent is suspended in a matrix.

18. The method of claim 1 , wherein the sensor device is configured to be inserted into the skin of the host with direct press insertion.

19. The method of claim 1 , wherein the sensor device is configured to remain in vivo for measurement of the analyte concentration within the skin of the host and configured to be removed from the skin of the host.

20. The method of claim 1 , further comprising coupling the wire to a mounting unit configured to remain ex vivo and adhere to a surface of the skin of the host when the sensor device is positioned within the skin of the host.

Assignees

• Dexcom Inc

Inventors

• Simpson Peter C
• Blackwell Jennifer
• Böhm Sebastian

Classifications

• A61B5/14865

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title

• A61B2017/00004

  (bio)absorbable, (bio)resorbable or resorptive · CPC title

• A61B17/3468

  for implanting or removing devices, e.g. prostheses, implants, seeds, wires (devices for implanting seeds A61M37/0069) · CPC title

• A61B5/4839

  combined with drug delivery · CPC title

• B21G1/12

  Securing, cleaning-off burrs, reconditioning polishing, grinding (takes precedence over B21G1/02 - B21G1/10) · CPC title