Apparatus and process for continuous adsorption

Patent metadata

Field	Value
Publication number	US-12005405-B2
Application number	US-201917257701-A
Country	US
Kind code	B2
Filing date	Jul 12, 2019
Priority date	Jul 12, 2018
Publication date	Jun 11, 2024
Grant date	Jun 11, 2024

Abstract

The invention relates to an apparatus for the continuous production of a particulate adsorption product, the apparatus comprising: a mixing drum having an elongated cavity for receiving a particulate adsorbent material, an adsorbent inlet and a product outlet, wherein the mixing drum is arranged such that the cavity is inclined in flow direction of the particulate material, and wherein the cavity comprises an initial transport zone adjacent to the inlet and a mixing zone following the initial transport zone; a rotating member extending through the cavity in a longitudinal direction, wherein the rotating member comprises a helical conveying blade at longitudinal positions corresponding to the initial transport zone and mixing instruments at longitudinal positions corresponding to the mixing zone; and one or more injection nozzles for injecting a liquid adsorbate to the mixing zone. The invention further relates to a process for the continuous production of a particulate adsorption product using such apparatus.

First claim

The invention claimed is:

1. A process for the continuous production of a particulate adsorption product using an apparatus comprising:
a mixing drum having an elongated cavity for receiving a particulate adsorbent material, an adsorbent inlet and a product outlet, wherein
the mixing drum is arranged such that the cavity is inclined in flow direction of the particulate material, and the cavity comprises an initial transport zone adjacent to the inlet and a mixing zone following the initial transport zone;
a rotating member extending through the cavity in a longitudinal direction, wherein the rotating member comprises a helical conveying blade at longitudinal positions corresponding to the initial transport zone and mixing instruments at longitudinal positions corresponding to the mixing zone; and
one or more injection nozzles for injecting a liquid adsorbate to the mixing zone, the process comprising the steps of:
continuously feeding a flowable particulate adsorbent material into the initial transport zone of the cavity through the inlet, wherein the particulate adsorbent material is a silica, charcoal, or zeolite material;
continuously injecting a liquid adsorbate into the mixing zone of the cavity through the nozzles, wherein the liquid adsorbate is a pure liquid active or a liquid solution or dispersion of an active, with the active being a biologically active component; and
continuously operating the rotating member to propagate the adsorbent through the initial transport zone to the mixing zone and to agitate the adsorbent and the adsorbate in the mixing zone.

2. The process of claim 1 , wherein the rotating member is operated at a rotational speed such that the peripheral speed of the helical conveying blade and the mixing instruments is 1 m/s or less.

3. The process of claim 1 , wherein the particulate adsorbent materials is a porous material having a specific surface area of at least 100 m 2 /g.

4. The process of claim 1 , wherein the feed rate of particulate adsorbent material and the rotational speed of the rotating member are adjusted such that the average residence time of the particulate material is between 2 and 20 minutes.

5. The process of claim 4 , wherein the feed rate of particulate adsorbent material and the rotational speed of the rotating member are adjusted such that the average residence time of the particulate material is between 5 and 10 minutes.

6. The process of claim 1 , wherein the cavity volume unoccupied by the particulate material is filled with ambient air.

7. The process of claim 1 , wherein the mixing instruments comprise mixing paddles.

8. The process of claim 7 , wherein the operative surfaces of the paddles are slanted backwards.

9. The process of claim 1 , wherein the cavity further comprises a terminal transport zone adjacent to the outlet and, at longitudinal positions corresponding to the terminal transport zone, the rotating member comprises a further helical conveyor blade.

10. The process of claim 1 , wherein the cavity further comprises a resting zone following the mixing zone and at longitudinal positions corresponding to the resting zone, the rotating member is devoid of mixing instruments or conveyor blades.

11. The process of claim 10 , wherein the cavity further comprises an intermediate transport zone between the mixing zone and the resting zone, or within the mixing zone, and, at longitudinal positions corresponding to the intermediate transport zone, the rotating member comprises another helical conveyor blade.

12. The process of claim 11 , wherein the resting zone extends over at least 10% of the length of the cavity and/or has a longitudinal extension that is equal or greater than the longitudinal extension of the initial transport zone, the terminal transport zone, the intermediate transport zone, or one of the mixing zones.

13. The process of claim 1 , wherein the incline angle is between 15 and 45° and/or wherein the L/D ratio of the cavity is between 2 and 10.

14. The process of claim 1 , wherein the incline angle and the length and diameter of the mixing zone are such that there are longitudinal positions within the mixing zone whose entire cross-section remains below the level of product removal.

15. The process of claim 14 , wherein the incline angle, the length of the mixing zone and the positions of the injection nozzles are such that all injection nozzles are located below the level of product removal.

16. The process of claim 1 , wherein the apparatus comprises a lifting device for adjusting the incline of the cavity.

17. The process of claim 16 , wherein the lifting device comprises one or more hydraulic cylinders.

18. The process of claim 12 , wherein the resting zone extends over at least 15% of the length of the cavity.

19. The process of claim 18 , wherein the resting zone extends over at least 20% of the length of the cavity.

20. The process of claim 13 , wherein the L/D ratio of the cavity is between 3 and 7.

21. The process of claim 7 , wherein the mixing paddles are distributed over the length of the mixing zone.

22. The process of claim 14 , wherein longitudinal positions whose entire cross-section remains below the level of product removal, account for at least 30% of all longitudinal positions within the mixing zone.

Assignees

• Dsm Ip Assets Bv

Inventors

• Riebel Peter
• Urban Kai

Classifications

• B01F2101/22

  Mixing of ingredients for pharmaceutical or medical compositions · CPC title

• B01F27/2123

  Shafts with both stirring means and feeding or discharging means · CPC title

• B01F27/231

  with a variable orientation during mixing operation, e.g. with tiltable rotor axis · CPC title

• B01F27/70

  with paddles, blades or arms · CPC title

• B01F27/62

  comprising liquid feeding, e.g. spraying means · CPC title